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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Arthrobacter aurescens (strain TC1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 778ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAUR290340:GI59-2891-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:AAur_2892
OrganismiArthrobacter aurescens (strain TC1)
Taxonomic identifieri290340 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000637: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Formate--tetrahydrofolate ligasePRO_0000293031Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290340.AAur_2892.

Structurei

3D structure databases

ProteinModelPortaliA1R8N9.
SMRiA1R8N9. Positions 9-560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1R8N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENKVLSDL EIAHNATMLP VEAIAERAGI NVDALELYGP YKAKINTAKL
60 70 80 90 100
VLPRGKAPGK VVLVSAMSPT PAGEGKSTTT VGLADSLARA GHKVMIALRE
110 120 130 140 150
PSLGPILGMK GGATGGGYSQ VLPMDDINLH FTGDFHAITS ANNALMALVD
160 170 180 190 200
NHIFQGNQLG IDPRRMTFKR VLDMNDRALR EVVIGLGGPM QGVPRQDGFD
210 220 230 240 250
ITVASEIMAV FCLATDLDDL RERLGRITFG YTYDRTPVTV SDLGVEGALT
260 270 280 290 300
MLLKDAIKPN LVQTIAGTPA LVHGGPFANI AHGCNSLIAT STAMQLADIV
310 320 330 340 350
VTEAGFGADL GAEKYMDIKA RIAEVAPSAV VVVATIRALK MQGGVPKEKL
360 370 380 390 400
NEPNVEAVAA GVENLKRHVG NVAKFGISPV VSINKFGSDT PEELEWLLAW
410 420 430 440 450
CAAEGVEAAV ADVWGRGGGG DGGDELAAKV AAALEAPSNF HHLYPLELGV
460 470 480 490 500
EDKIRTIVQE IYGADGVEFS VPALKRLAEI EKNGWSGLPV CMAKTQYSFT
510 520 530 540 550
DDASRLGAPK GFRVHVRELI PKTGAGFIVA LTGAVMTMPG LPKEPAAMRM
560
DVDADGNPTG LF
Length:562
Mass (Da):59,201
Last modified:February 6, 2007 - v1
Checksum:i994851454A18EF7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000474 Genomic DNA. Translation: ABM10024.1.
RefSeqiWP_011775541.1. NC_008711.1.
YP_948601.1. NC_008711.1.

Genome annotation databases

EnsemblBacteriaiABM10024; ABM10024; AAur_2892.
GeneIDi4639848.
KEGGiaau:AAur_2892.
PATRICi20981264. VBIArtAur67810_2940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000474 Genomic DNA. Translation: ABM10024.1.
RefSeqiWP_011775541.1. NC_008711.1.
YP_948601.1. NC_008711.1.

3D structure databases

ProteinModelPortaliA1R8N9.
SMRiA1R8N9. Positions 9-560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290340.AAur_2892.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM10024; ABM10024; AAur_2892.
GeneIDi4639848.
KEGGiaau:AAur_2892.
PATRICi20981264. VBIArtAur67810_2940.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciAAUR290340:GI59-2891-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TC1.

Entry informationi

Entry nameiFTHS_ARTAT
AccessioniPrimary (citable) accession number: A1R8N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 6, 2007
Last modified: March 4, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.