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A1R8N9 (FTHS_ARTAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:AAur_2892
OrganismArthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]
Taxonomic identifier290340 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 562562Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293031

Regions

Nucleotide binding70 – 778ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1R8N9 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 994851454A18EF7C

FASTA56259,201
        10         20         30         40         50         60 
MSENKVLSDL EIAHNATMLP VEAIAERAGI NVDALELYGP YKAKINTAKL VLPRGKAPGK 

        70         80         90        100        110        120 
VVLVSAMSPT PAGEGKSTTT VGLADSLARA GHKVMIALRE PSLGPILGMK GGATGGGYSQ 

       130        140        150        160        170        180 
VLPMDDINLH FTGDFHAITS ANNALMALVD NHIFQGNQLG IDPRRMTFKR VLDMNDRALR 

       190        200        210        220        230        240 
EVVIGLGGPM QGVPRQDGFD ITVASEIMAV FCLATDLDDL RERLGRITFG YTYDRTPVTV 

       250        260        270        280        290        300 
SDLGVEGALT MLLKDAIKPN LVQTIAGTPA LVHGGPFANI AHGCNSLIAT STAMQLADIV 

       310        320        330        340        350        360 
VTEAGFGADL GAEKYMDIKA RIAEVAPSAV VVVATIRALK MQGGVPKEKL NEPNVEAVAA 

       370        380        390        400        410        420 
GVENLKRHVG NVAKFGISPV VSINKFGSDT PEELEWLLAW CAAEGVEAAV ADVWGRGGGG 

       430        440        450        460        470        480 
DGGDELAAKV AAALEAPSNF HHLYPLELGV EDKIRTIVQE IYGADGVEFS VPALKRLAEI 

       490        500        510        520        530        540 
EKNGWSGLPV CMAKTQYSFT DDASRLGAPK GFRVHVRELI PKTGAGFIVA LTGAVMTMPG 

       550        560 
LPKEPAAMRM DVDADGNPTG LF 

« Hide

References

[1]"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1."
Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.
PLoS Genet. 2:2094-2106(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TC1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000474 Genomic DNA. Translation: ABM10024.1.
RefSeqYP_948601.1. NC_008711.1.

3D structure databases

ProteinModelPortalA1R8N9.
SMRA1R8N9. Positions 9-560.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290340.AAur_2892.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM10024; ABM10024; AAur_2892.
GeneID4639848.
KEGGaau:AAur_2892.
PATRIC20981264. VBIArtAur67810_2940.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycAAUR290340:GI59-2891-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_ARTAT
AccessionPrimary (citable) accession number: A1R8N9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways