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A1R8N9

- FTHS_ARTAT

UniProt

A1R8N9 - FTHS_ARTAT

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, AAur_2892
Organism
Arthrobacter aurescens (strain TC1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 778ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAUR290340:GI59-2891-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:AAur_2892
OrganismiArthrobacter aurescens (strain TC1)
Taxonomic identifieri290340 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000637: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000293031Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290340.AAur_2892.

Structurei

3D structure databases

ProteinModelPortaliA1R8N9.
SMRiA1R8N9. Positions 9-560.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1R8N9-1 [UniParc]FASTAAdd to Basket

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MSENKVLSDL EIAHNATMLP VEAIAERAGI NVDALELYGP YKAKINTAKL    50
VLPRGKAPGK VVLVSAMSPT PAGEGKSTTT VGLADSLARA GHKVMIALRE 100
PSLGPILGMK GGATGGGYSQ VLPMDDINLH FTGDFHAITS ANNALMALVD 150
NHIFQGNQLG IDPRRMTFKR VLDMNDRALR EVVIGLGGPM QGVPRQDGFD 200
ITVASEIMAV FCLATDLDDL RERLGRITFG YTYDRTPVTV SDLGVEGALT 250
MLLKDAIKPN LVQTIAGTPA LVHGGPFANI AHGCNSLIAT STAMQLADIV 300
VTEAGFGADL GAEKYMDIKA RIAEVAPSAV VVVATIRALK MQGGVPKEKL 350
NEPNVEAVAA GVENLKRHVG NVAKFGISPV VSINKFGSDT PEELEWLLAW 400
CAAEGVEAAV ADVWGRGGGG DGGDELAAKV AAALEAPSNF HHLYPLELGV 450
EDKIRTIVQE IYGADGVEFS VPALKRLAEI EKNGWSGLPV CMAKTQYSFT 500
DDASRLGAPK GFRVHVRELI PKTGAGFIVA LTGAVMTMPG LPKEPAAMRM 550
DVDADGNPTG LF 562
Length:562
Mass (Da):59,201
Last modified:February 6, 2007 - v1
Checksum:i994851454A18EF7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000474 Genomic DNA. Translation: ABM10024.1.
RefSeqiYP_948601.1. NC_008711.1.

Genome annotation databases

EnsemblBacteriaiABM10024; ABM10024; AAur_2892.
GeneIDi4639848.
KEGGiaau:AAur_2892.
PATRICi20981264. VBIArtAur67810_2940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000474 Genomic DNA. Translation: ABM10024.1 .
RefSeqi YP_948601.1. NC_008711.1.

3D structure databases

ProteinModelPortali A1R8N9.
SMRi A1R8N9. Positions 9-560.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290340.AAur_2892.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM10024 ; ABM10024 ; AAur_2892 .
GeneIDi 4639848.
KEGGi aau:AAur_2892.
PATRICi 20981264. VBIArtAur67810_2940.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci AAUR290340:GI59-2891-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TC1.

Entry informationi

Entry nameiFTHS_ARTAT
AccessioniPrimary (citable) accession number: A1R8N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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