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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Paenarthrobacter aurescens (strain TC1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi70 – 77ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAUR290340:G1G7H-2901-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:AAur_2892
OrganismiPaenarthrobacter aurescens (strain TC1)
Taxonomic identifieri290340 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePaenarthrobacter
Proteomesi
  • UP000000637 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002930311 – 562Formate--tetrahydrofolate ligaseAdd BLAST562

Proteomic databases

PRIDEiA1R8N9

Interactioni

Protein-protein interaction databases

STRINGi290340.AAur_2892

Structurei

3D structure databases

ProteinModelPortaliA1R8N9
SMRiA1R8N9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit

Sequencei

Sequence statusi: Complete.

A1R8N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENKVLSDL EIAHNATMLP VEAIAERAGI NVDALELYGP YKAKINTAKL
60 70 80 90 100
VLPRGKAPGK VVLVSAMSPT PAGEGKSTTT VGLADSLARA GHKVMIALRE
110 120 130 140 150
PSLGPILGMK GGATGGGYSQ VLPMDDINLH FTGDFHAITS ANNALMALVD
160 170 180 190 200
NHIFQGNQLG IDPRRMTFKR VLDMNDRALR EVVIGLGGPM QGVPRQDGFD
210 220 230 240 250
ITVASEIMAV FCLATDLDDL RERLGRITFG YTYDRTPVTV SDLGVEGALT
260 270 280 290 300
MLLKDAIKPN LVQTIAGTPA LVHGGPFANI AHGCNSLIAT STAMQLADIV
310 320 330 340 350
VTEAGFGADL GAEKYMDIKA RIAEVAPSAV VVVATIRALK MQGGVPKEKL
360 370 380 390 400
NEPNVEAVAA GVENLKRHVG NVAKFGISPV VSINKFGSDT PEELEWLLAW
410 420 430 440 450
CAAEGVEAAV ADVWGRGGGG DGGDELAAKV AAALEAPSNF HHLYPLELGV
460 470 480 490 500
EDKIRTIVQE IYGADGVEFS VPALKRLAEI EKNGWSGLPV CMAKTQYSFT
510 520 530 540 550
DDASRLGAPK GFRVHVRELI PKTGAGFIVA LTGAVMTMPG LPKEPAAMRM
560
DVDADGNPTG LF
Length:562
Mass (Da):59,201
Last modified:February 6, 2007 - v1
Checksum:i994851454A18EF7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000474 Genomic DNA Translation: ABM10024.1
RefSeqiWP_011775541.1, NC_008711.1

Genome annotation databases

EnsemblBacteriaiABM10024; ABM10024; AAur_2892
GeneIDi29622480
KEGGiaau:AAur_2892

Similar proteinsi

Entry informationi

Entry nameiFTHS_PAEAT
AccessioniPrimary (citable) accession number: A1R8N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health