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A1R8N9

- FTHS_ARTAT

UniProt

A1R8N9 - FTHS_ARTAT

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Arthrobacter aurescens (strain TC1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi70 – 778ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAAUR290340:GI59-2891-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:AAur_2892
    OrganismiArthrobacter aurescens (strain TC1)
    Taxonomic identifieri290340 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
    ProteomesiUP000000637: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Formate--tetrahydrofolate ligasePRO_0000293031Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290340.AAur_2892.

    Structurei

    3D structure databases

    ProteinModelPortaliA1R8N9.
    SMRiA1R8N9. Positions 9-560.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1R8N9-1 [UniParc]FASTAAdd to Basket

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    MSENKVLSDL EIAHNATMLP VEAIAERAGI NVDALELYGP YKAKINTAKL    50
    VLPRGKAPGK VVLVSAMSPT PAGEGKSTTT VGLADSLARA GHKVMIALRE 100
    PSLGPILGMK GGATGGGYSQ VLPMDDINLH FTGDFHAITS ANNALMALVD 150
    NHIFQGNQLG IDPRRMTFKR VLDMNDRALR EVVIGLGGPM QGVPRQDGFD 200
    ITVASEIMAV FCLATDLDDL RERLGRITFG YTYDRTPVTV SDLGVEGALT 250
    MLLKDAIKPN LVQTIAGTPA LVHGGPFANI AHGCNSLIAT STAMQLADIV 300
    VTEAGFGADL GAEKYMDIKA RIAEVAPSAV VVVATIRALK MQGGVPKEKL 350
    NEPNVEAVAA GVENLKRHVG NVAKFGISPV VSINKFGSDT PEELEWLLAW 400
    CAAEGVEAAV ADVWGRGGGG DGGDELAAKV AAALEAPSNF HHLYPLELGV 450
    EDKIRTIVQE IYGADGVEFS VPALKRLAEI EKNGWSGLPV CMAKTQYSFT 500
    DDASRLGAPK GFRVHVRELI PKTGAGFIVA LTGAVMTMPG LPKEPAAMRM 550
    DVDADGNPTG LF 562
    Length:562
    Mass (Da):59,201
    Last modified:February 6, 2007 - v1
    Checksum:i994851454A18EF7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000474 Genomic DNA. Translation: ABM10024.1.
    RefSeqiYP_948601.1. NC_008711.1.

    Genome annotation databases

    EnsemblBacteriaiABM10024; ABM10024; AAur_2892.
    GeneIDi4639848.
    KEGGiaau:AAur_2892.
    PATRICi20981264. VBIArtAur67810_2940.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000474 Genomic DNA. Translation: ABM10024.1 .
    RefSeqi YP_948601.1. NC_008711.1.

    3D structure databases

    ProteinModelPortali A1R8N9.
    SMRi A1R8N9. Positions 9-560.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290340.AAur_2892.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM10024 ; ABM10024 ; AAur_2892 .
    GeneIDi 4639848.
    KEGGi aau:AAur_2892.
    PATRICi 20981264. VBIArtAur67810_2940.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci AAUR290340:GI59-2891-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TC1.

    Entry informationi

    Entry nameiFTHS_ARTAT
    AccessioniPrimary (citable) accession number: A1R8N9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3