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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Arthrobacter aurescens (strain TC1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71D-inositol 3-phosphateUniRule annotation1
Binding sitei21UDP-GlcNAc; via amide nitrogenUniRule annotation1
Binding sitei761D-inositol 3-phosphateUniRule annotation1
Binding sitei1091D-inositol 3-phosphateUniRule annotation1
Binding sitei1331D-inositol 3-phosphateUniRule annotation1
Binding sitei1531D-inositol 3-phosphateUniRule annotation1
Binding sitei227UDP-GlcNAcUniRule annotation1
Binding sitei232UDP-GlcNAcUniRule annotation1
Binding sitei288UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi297Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi298Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi300Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei310UDP-GlcNAcUniRule annotation1
Binding sitei318UDP-GlcNAcUniRule annotation1
Metal bindingi324MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:AAur_2891
OrganismiArthrobacter aurescens (strain TC1)
Taxonomic identifieri290340 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePaenarthrobacter
Proteomesi
  • UP000000637 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001091 – 408D-inositol 3-phosphate glycosyltransferaseAdd BLAST408

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290340.AAur_2891.

Structurei

3D structure databases

ProteinModelPortaliA1R8N8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 14UDP-GlcNAc bindingUniRule annotation2
Regioni18 – 231D-inositol 3-phosphate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

A1R8N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLSLHTSP MEQPGAGDAG GMNVYVRALA MALAESGVEV EIFTRSTKAG
60 70 80 90 100
QPAVEHPGPG VCVHNVMAGP RRKLPKEELP ELLHHMVEEI DRIRLQQLHG
110 120 130 140 150
RYDAIHSHYW VSGVAGLELS ELWGVPLVHT MHTMAKVKNL VLESGERPEP
160 170 180 190 200
RRREEGEQRI VDGAARLVAN TPAEADELVS HYGADLDRID VAPPGVDLKV
210 220 230 240 250
FTPSFRRKSR SLRGVRPDSF HILFAGRIQR LKGPQVFVKA AGILRKRRPD
260 270 280 290 300
IDLEMTILGS LSGAKDFNLQ HFIEDAGLAD VVTHRPPVVA PELASWFRSA
310 320 330 340 350
DVVVMPSFSE SFGLVALEAQ ACGTPVVATN VGGLSRAISD GRTGILVDGH
360 370 380 390 400
HPSDWADALE DLYDDVQTRE DMGRLAATHA ESFGWQRTAA ITLESYREAV

SGLLVPRR
Length:408
Mass (Da):44,654
Last modified:February 6, 2007 - v1
Checksum:i6677D1728B4A3008
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000474 Genomic DNA. Translation: ABM08761.1.

Genome annotation databases

EnsemblBacteriaiABM08761; ABM08761; AAur_2891.
KEGGiaau:AAur_2891.
PATRICi20981262. VBIArtAur67810_2939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000474 Genomic DNA. Translation: ABM08761.1.

3D structure databases

ProteinModelPortaliA1R8N8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290340.AAur_2891.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM08761; ABM08761; AAur_2891.
KEGGiaau:AAur_2891.
PATRICi20981262. VBIArtAur67810_2939.

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHA_ARTAT
AccessioniPrimary (citable) accession number: A1R8N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.