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A1R8K4 (A1R8K4_ARTAT) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing] HAMAP-Rule MF_00344
EC=6.3.5.2 HAMAP-Rule MF_00344
Alternative name(s):
GMP synthetase HAMAP-Rule MF_00344
Glutamine amidotransferase HAMAP-Rule MF_00344
Gene names
Name:guaA HAMAP-Rule MF_00344 EMBL ABM08742.1
Ordered Locus Names:AAur_2857 EMBL ABM08742.1
OrganismArthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP] EMBL ABM08742.1
Taxonomic identifier290340 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter ›

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP-Rule MF_00344 SAAS SAAS022955

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP-Rule MF_00344 SAAS SAAS022955

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP-Rule MF_00344 SAAS SAAS022955

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00344 SAAS SAAS022955

Sequence similarities

Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain. HAMAP-Rule MF_00344 SAAS SAAS022955

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_00344 SAAS SAAS022955

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain13 – 204192Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_00344
Domain205 – 403199GMPS ATP-PPase By similarity HAMAP-Rule MF_00344
Nucleotide binding232 – 2387ATP By similarity HAMAP-Rule MF_00344

Sites

Active site901Nucleophile By similarity HAMAP-Rule MF_00344
Active site1781 By similarity HAMAP-Rule MF_00344
Active site1801 By similarity HAMAP-Rule MF_00344

Sequences

Sequence LengthMass (Da)Tools
A1R8K4 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 6E7925F74CF661FD

FASTA52956,647
        10         20         30         40         50         60 
MTTPTAPQTS QKPVLVVDYG AQYAQLIARR VREANVYSEI VPHTFTTEQL LAKNPAAIIL 

        70         80         90        100        110        120 
SGGPSSVYAE GAPSVGADLF EAGVPVFGIC YGFQAMANAL GGKVAQTGLR EYGATEALVV 

       130        140        150        160        170        180 
GDARSILDGV PSSQNTWMSH GDSVHEAPEG FEVLASTAGA PVAAFANDEK RLYGVQWHPE 

       190        200        210        220        230        240 
VKHSVHGQHV LENFLFKGAG LSPNWTTGNI LEEQVDRIRQ QIGDSKVICG LSGGVDSAVA 

       250        260        270        280        290        300 
AALVQRAVGD QLTCVFVDHG LLREGEAEQV ERDFVAATGV NLYVANEQER FQSALAGVSD 

       310        320        330        340        350        360 
PETKRKIIGR EFIRAFEEAE RAIIAQAAAE GEKIKFLVQG TLYPDVVESG GGEGAANIKS 

       370        380        390        400        410        420 
HHNVGGLPED LQFELVEPLR ALFKDEVRAV GAQLGLPQEI VGRQPFPGPG LGIRIVGEVT 

       430        440        450        460        470        480 
KERLDLLRKA DAIARAELTA AGLDNDVWQM PVVLLADVRS VGVQGDGRTY GHPIVLRPVS 

       490        500        510        520 
SEDAMTADWS RLPYDLLARI SNRITNEVDG VNRVVLDVTS KPPGTIEWE

« Hide

References

[1]"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1."
Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartsbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.
PLoS Genet. 2:e214-e214(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TC1 EMBL ABM08742.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000474 Genomic DNA. Translation: ABM08742.1.
RefSeqYP_948566.1. NC_008711.1.

3D structure databases

ProteinModelPortalA1R8K4.
ModBaseSearch...

Protein-protein interaction databases

STRING290340.AAur_2857.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM08742; ABM08742; AAur_2857.
GeneID4638506.
KEGGaau:AAur_2857.
PATRIC20981194. VBIArtAur67810_2905.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0519.
HOGENOMHOG000223964.
KOK01951.
OMAYDYVVAL.
ProtClustDBPRK00074.

Enzyme and pathway databases

BioCycAAUR290340:GI59-3441-MONOMER.
UniPathwayUPA00189; UER00296.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00344. GMP_synthase.
InterProIPR017926. GATASE_1.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1R8K4_ARTAT
AccessionPrimary (citable) accession number: A1R8K4
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info