A1R7X2 (SYR_ARTAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	AAur_2614

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 549	549	Arginine--tRNA ligase HAMAP MF_00123		PRO_1000017985
Regions
	Motif	132 – 142	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	A1R7X2 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 39DF2C0707751AFB	FASTA	549	59,204
	10 20 30 40 50 60 MTPEELSAAI SACLKDAVST GEIALTESAV PDAVRVERPK NRDHGDWATN IALQLSKQAG 70 80 90 100 110 120 MNPREFAGIL SNHLQGIPGV TGVEIAGPGF LNITVDAATA GALAKAIVEA GASYGTNQAL 130 140 150 160 170 180 AGRVVNMEFV SANPTGPLHI GHTRWAALGD AIARVLRASG ADVTAEYYIN DAGSQMNVFA 190 200 210 220 230 240 NSVLSRLHGR GVPEGGYPGE YIRELGDEVL KAHPGIRELT DEAALPVIRA AAYEAQMSDI 250 260 270 280 290 300 KTTLAEFGVE FDVFFSEKEL HDAGAIESAV ARLREQGHVF DDGGAVWLRT TDFGDDKDRV 310 320 330 340 350 360 MIRANGEPTY FAADAAYYLS KKDRGFTEKI YLLGADHHGY INRLKAIAAC AGDDPEVNIE 370 380 390 400 410 420 VLIGQLVSVN GAKLSKRAGN IIELKDLISW LGKDAVRYSL ARFPADSPLT LDPELLKKHS 430 440 450 460 470 480 NENPVFYVQY AHARSRGTAR NAAEAGVDRS VFDASLLDHA TENELLSYLG SYPSIVAKAA 490 500 510 520 530 540 ELREPHRVAR HLEVIAGAYH RWYDACRVSP QGEEPVLDVN RTRLWLNDAT SQVLANGLEL LGVSAPERM

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000474 Genomic DNA. Translation: ABM06929.1.
RefSeq	YP_948334.1. NC_008711.1.
3D structure databases
ProteinModelPortal	A1R7X2.
ModBase	Search...
Protein-protein interaction databases
STRING	A1R7X2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4637309.
GenomeReviews	Gene locus AAur_2614 in contig CP000474_GR.
KEGG	aau:AAur_2614.
PATRIC	20980672. VBIArtAur67810_2648.
TIGR	AAur_2614.
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HBG695395.
OMA	FDVYFHE.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	AAUR290340:AAUR_2614-MONOMER.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_ARTAT

Accession

Primary (citable) accession number: A1R7X2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program