ID   TRMD_ARTAT              Reviewed;         266 AA.
AC   A1R7G3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=tRNA (guanine-N(1)-)-methyltransferase;
DE            EC=2.1.1.31;
DE   AltName: Full=M1G-methyltransferase;
DE   AltName: Full=tRNA [GM37] methyltransferase;
GN   Name=trmD; OrderedLocusNames=AAur_2449;
OS   Arthrobacter aurescens (strain TC1).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micrococcineae; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=290340;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17194220; DOI=10.1371/journal.pgen.0020214;
RA   Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B.,
RA   Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V.,
RA   Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.;
RT   "Secrets of soil survival revealed by the genome sequence of
RT   Arthrobacter aurescens TC1.";
RL   PLoS Genet. 2:2094-2106(2006).
CC   -!- FUNCTION: Specifically methylates guanosine-37 in various tRNAs
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-
CC       homocysteine + tRNA containing N(1)-methylguanine.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the RNA methyltransferase trmD family.
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DR   EMBL; CP000474; ABM06607.1; -; Genomic_DNA.
DR   RefSeq; YP_948175.1; -.
DR   GeneID; 4638249; -.
DR   GenomeReviews; CP000474_GR; AAur_2449.
DR   KEGG; aau:AAur_2449; -.
DR   TIGR; AAur_2449; -.
DR   OMA; A1R7G3; HRSVDDT.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0009019; F:tRNA (guanine-N1-)-methyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006400; P:tRNA modification; IEA:HAMAP.
DR   HAMAP; MF_00605; -; 1.
DR   InterPro; IPR016009; tRNA_m1G_MeTrfase.
DR   InterPro; IPR002649; tRNA_m1G_MeTrfase_bac.
DR   Pfam; PF01746; tRNA_m1G_MT; 1.
DR   PIRSF; PIRSF000386; tRNA_mtase; 1.
DR   ProDom; PD004978; tRNA_m1G_mtfrase; 1.
DR   TIGRFAMs; TIGR00088; trmD; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase;
KW   S-adenosyl-L-methionine; Transferase; tRNA processing.
FT   CHAIN         1    266       tRNA (guanine-N(1)-)-methyltransferase.
FT                                /FTId=PRO_1000006447.
FT   REGION      137    142       S-adenosyl-L-methionine binding (By
FT                                similarity).
FT   BINDING     113    113       S-adenosyl-L-methionine; via amide
FT                                nitrogen (By similarity).
SQ   SEQUENCE   266 AA;  29401 MW;  5A151BA98DD0BCD2 CRC64;
     MRIDVVSIFP EYLAPLELSL IGKARQDGLL ELNVHDLRTF TTDKHRTVDD TPYGGGAGMV
     MKPEPWAQAL ESVAAARENS KPVLIVPSPA GEKFNQALAY ELAEEEQLVF ACGRYEGIDE
     RVIDWAQDHF RVRPVSLGDY VLNGGEVAVL AMVEAIGRLL PGVVGNPESL VEESHSDGLL
     EYPVYTKPSA WRDHDVPPIL LSGNHGKIAQ WRRHEQFRRT AERRPDLMEG LDAGVLSRAD
     RQALADLGYD VVDGRLRAKP GGDTEN
//