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A1R7F2 (A1R7F2_ARTAT) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:AAur_2436
OrganismArthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP] EMBL ABM07270.1
Taxonomic identifier290340 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region279 – 2835ACP-binding By similarity HAMAP MF_01815

Sites

Active site1241 By similarity HAMAP MF_01815
Active site2781 By similarity HAMAP MF_01815
Active site3091 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
A1R7F2 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 965DBFAA12EFBB6B

FASTA35337,019
        10         20         30         40         50         60 
MSTPVLNKTA VNENARILGI GAYRPDVIVT NDDVCQWIDS SDEWIRQRTG IITRHRAAAD 

        70         80         90        100        110        120 
VSVIDMAEGA AREALKQAGI EPSQLGAVIV STVTHPYATP SAAAALTDRL GATPAPAFDI 

       130        140        150        160        170        180 
SAACAGYCYG VAQADALVRS GAAEYVLVVG AEKLSDVIDN HERTISFLLG DGAGAVVVGP 

       190        200        210        220        230        240 
SDTPGIGPSV WGSDGSKWDA IGMTHSLEDV KKLGESARHS DEIDDPAILS ATQDVWPTLR 

       250        260        270        280        290        300 
QDGQTVFRWA VWEMAKVAQQ ALDAAGIEAS DLAAFVPHQA NMRIIDEMVK KLKLPESVVI 

       310        320        330        340        350 
GRDIAQAGNT SAASIPLATH RLLQENPELS GGLALQIGFG AGLVFGAQVV VLP

« Hide

References

[1]"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1."
Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.
PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000474 Genomic DNA. Translation: ABM07270.1.
RefSeqYP_948164.1. NC_008711.1.

3D structure databases

ProteinModelPortalA1R7F2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1R7F2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4641087.
GenomeReviewsGene locus AAur_2436 in contig CP000474_GR.
KEGGaau:AAur_2436.
PATRIC20980302. VBIArtAur67810_2468.
TIGRAAur_2436.

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMAATRIEND.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 3 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA1R7F2_ARTAT
AccessionPrimary (citable) accession number: A1R7F2
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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