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A1R7E9 (A1R7E9_ARTAT) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Ordered Locus Names:AAur_2433
OrganismArthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP] EMBL ABM06738.1
Taxonomic identifier290340 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length932 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
A1R7E9 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: C9BB9B6DDA525D29

FASTA932103,171
        10         20         30         40         50         60 
MHAPKGRLDV AAGEETSHIL SGLTAQLPDR DPEETAEWIE SLDALIAEQG TERAQYIMRS 

        70         80         90        100        110        120 
LLQRAGARSV GVPMVTTTDY VNTIPVDQEA QFPGNEEFER RYRAYMRWNA AVMVHRAQRS 

       130        140        150        160        170        180 
DIGVGGHIST YAGAATLYEV GFNHFFRGKD HPSGGDQVFF QGHASPGMYA RAFMEGRLTE 

       190        200        210        220        230        240 
EDLDGFRQEK SKAGHALSSY PHPRLMPDFW EFPTVSMGIG PMNAIYQAQS NRYLQNRGIK 

       250        260        270        280        290        300 
DTSDQQVWAF LGDGEMDEPE SRGLLQLAAN ENLDNLNFVI NCNLQRLDGP VRGNGKIMQE 

       310        320        330        340        350        360 
LEAFFRGAGW NVIKVVWGRE WDSLLEADTD GALVKIMNET PDGDYQTYKA ESGGFVREHF 

       370        380        390        400        410        420 
FGKSPQTKDM VADLDDEQIW GLKRGGHDYR KVYAAYKAAT EFKGKPTVIL AKTVKGYGLG 

       430        440        450        460        470        480 
PHFEGRNATH QMKKLTMEDL KAFRDHLRIP ISDDQLDADL YRPPYYHPGM DAPEIKYLME 

       490        500        510        520        530        540 
RRAELGGFVP ERRRKHTEVV LPEAKSYEVA KRGSGKQQAA TTMAFVRLLK DLMRDKNFGA 

       550        560        570        580        590        600 
RFVPVVPDES RTFGMDAFFP TAKIYNPKGQ NYLSVDRDLV LAYKESPAGQ LIHPGINEAG 

       610        620        630        640        650        660 
AVAAFTAAGT AYATHGEPLV PIYVFYSMFG FQRTGDSFWA AADQMTRGFI IGATAGRTTL 

       670        680        690        700        710        720 
TGEGLQHADG HSPILASTNP AVKTYDPAYG YEIGHIIRHG LEEMYGPDST DGTGEDRNVM 

       730        740        750        760        770        780 
YYLTVYNEPI TQPAEPDNLD INGLLKGIYK LADAPETTGN GNRPTATILA SGVSVPWALE 

       790        800        810        820        830        840 
AQRILNEDWN VAAEVWSVTS WNELRRDGLA AEEHAFLNPG QPARTPFITE QLKDTNGPVI 

       850        860        870        880        890        900 
AVSDYMKAVP DQIRQFIPND FASLGADGFG FSDTRQAARR YFKNDTHSIV AKTLQLLAAK 

       910        920        930 
GEVEAGALEK AIEKYRLLDV NAGTTGGAGG DA

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References

[1]"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1."
Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.
PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000474 Genomic DNA. Translation: ABM06738.1.
RefSeqYP_948161.1. NC_008711.1.

3D structure databases

ProteinModelPortalA1R7E9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1R7E9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4639405.
GenomeReviewsGene locus AAur_2433 in contig CP000474_GR.
KEGGaau:AAur_2433.
PATRIC20980296. VBIArtAur67810_2465.
TIGRAAur_2433.

Phylogenomic databases

eggNOGCOG2609.
HOGENOMHBG289271.
OMASGRTTIN.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA1R7E9_ARTAT
AccessionPrimary (citable) accession number: A1R7E9
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info