A1R7A4 (A1R7A4_ARTAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit 2 HAMAP MF_00444
EC=3.4.21.92 HAMAP MF_00444

Alternative name(s):
Endopeptidase Clp 2 HAMAP MF_00444

Gene names

Name:	clpP EMBL ABM09244.1
Synonyms:	clpP2 HAMAP MF_00444
Ordered Locus Names:	AAur_2382

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP] EMBL ABM09244.1

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family. HAMAP MF_00444

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00444
Ligand	ATP-binding HAMAP MF_00444 Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease HAMAP MF_00444
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	100	1	By similarity HAMAP MF_00444
	Active site	125	1	By similarity HAMAP MF_00444

Sequences

	Sequence		Length	Mass (Da)
	A1R7A4 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 684424AA442929E4	FASTA	212	22,811
	10 20 30 40 50 60 MSQQSEAPRM ATVDPAAQDN YIYNRLLKER IIWLGSEVRD ENANAICSQL LLLSAEDPEK 70 80 90 100 110 120 DIYLYINSPG GSVTAGMAIY DTMQFIPNDV VTVATGLAAS MGQFLLSSGT KGKRYATPNA 130 140 150 160 170 180 RILMHQPSGG IGGTASDIKI QAELILHMKK VMAELTAEQT GQSVETILKD NDRDKWFTAT 190 200 210 EALEYGFFDK ISAHAGSVAG GGGTANQSNS EN

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000474 Genomic DNA. Translation: ABM09244.1.
RefSeq	YP_948116.1. NC_008711.1.
3D structure databases
ProteinModelPortal	A1R7A4.
SMR	A1R7A4. Positions 22-195.
ModBase	Search...
Protein-protein interaction databases
STRING	A1R7A4.
Protein family/group databases
MEROPS	S14.008.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4638150.
GenomeReviews	Gene locus AAur_2382 in contig CP000474_GR.
KEGG	aau:AAur_2382.
PATRIC	20980194. VBIArtAur67810_2419.
TIGR	AAur_2382.
Phylogenomic databases
eggNOG	COG0740.
HOGENOM	HBG558421.
OMA	NAICAQL.
ProtClustDB	CLSK959937.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1R7A4_ARTAT

Accession

Primary (citable) accession number: A1R7A4

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)