Reviewed, UniProtKB/Swiss-Prot A1R705 (AROC_ARTAT)

Names and origin

Protein names

Recommended name:
    Chorismate synthase
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	AAur_2277

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Chorismate synthase HAMAP MF_00300		PRO_0000322386

Sequences

	Sequence		Length	Mass (Da)
	A1R705-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: E42C5AA560585FC9	FASTA	399	42,361
	10 20 30 40 50 60 MLRWLTAGES HGPALIGIVE GVPAGVELTS GQIRDALARR RLGYGRGARM KFEQDEVTIM 70 80 90 100 110 120 GGVRHGLTQG GPVAIQVGNT EWPKWEQIMS ADPVDPEVLA DQARNAPLTR PRPGHADFTG 130 140 150 160 170 180 MQKYGFDEAR PVLERASARE TATRVALGTV AAQFLKQLGI ELVSHTVSIA SVTVPEGRPL 190 200 210 220 230 240 PLPKDVIALD ADPLRCFDRE TSNAMVAEVD AAHKEGETLG GVVEVLAYGL PPGLGSYVHW 250 260 270 280 290 300 DRRLDSRLAA ALMGIQAIKG VEVGDGFLTA ARRGSAAHDE ILKDENGKIV RQTNRAGGIE 310 320 330 340 350 360 GGMSIGEVLR VRAAMKPIAT VPRALRTIDV STGEPAKAHH QRSDVCAVPA AGVVAEAMVA 370 380 390 LVLAEAVAEK FGGDSVPETQ RNLQSYLESI PATLDSVGR

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000474 Genomic DNA. Translation: ABM09327.1. Different initiation.
RefSeq	YP_948017.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1R705.
Genome annotation databases
GeneID	4639476.
GenomeReviews	Gene locus AAur_2277 in contig CP000474_GR.
KEGG	aau:AAur_2277.
TIGR	AAur_2277.
Family and domain databases
HAMAP	MF_00300. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
ProDom	PD002941. Chorismate_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_ARTAT

Accession

Primary (citable) accession number: A1R705

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	September 22, 2009
This is version 19 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)