Reviewed, UniProtKB/Swiss-Prot A1R703 (AROB_ARTAT)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	AAur_2275

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094452

Sequences

	Sequence		Length	Mass (Da)
	A1R703-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: EE395A3473F1AAA1	FASTA	363	39,082
	10 20 30 40 50 60 MSNEATVIKV TGQSVNENYD VVVGRGLLDT LPAKLGERVR RVLVIHPRAL RLTGDTVRDE 70 80 90 100 110 120 LEAAGFTALT AEIPDAEEGK HIQVAAFCWQ VLGQNDFTRS DAIVAVGGGA VTDLAGFVAA 130 140 150 160 170 180 TWLRGVKVIH MPTSLLGMVD ASVGGKTGIN TAEGKNLVGS FHPPAAVLAD LDTLQTLPKN 190 200 210 220 230 240 ELISGMAEVI KCGFIADPAI LDLVEKNTDA VMDPGSDVVR ELIERAISVK ADVVSQDLKE 250 260 270 280 290 300 SGLREILNYG HTLGHAIELV ERYSWRHGAA VSVGMMFAAE LSRSVGRLSD ADADRHRTIL 310 320 330 340 350 360 ESLGLPITYR RDRWQGLLDG MRRDKKSRGD LLRFVVLDGV AKPGILEVPD TSLLFAAYQE IAS

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000474 Genomic DNA. Translation: ABM06788.1.
RefSeq	YP_948015.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1R703.
Genome annotation databases
GeneID	4637745.
GenomeReviews	Gene locus AAur_2275 in contig CP000474_GR.
KEGG	aau:AAur_2275.
TIGR	AAur_2275.
Phylogenomic databases
OMA	LGEVIKY.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_ARTAT

Accession

Primary (citable) accession number: A1R703

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)