ID   PYRB_ARTAT              Reviewed;         335 AA.
AC   A1R6Z7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   16-JUN-2009, entry version 18.
DE   RecName: Full=Aspartate carbamoyltransferase;
DE            EC=2.1.3.2;
DE   AltName: Full=Aspartate transcarbamylase;
DE            Short=ATCase;
GN   Name=pyrB; OrderedLocusNames=AAur_2269;
OS   Arthrobacter aurescens (strain TC1).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micrococcineae; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=290340;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17194220; DOI=10.1371/journal.pgen.0020214;
RA   Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B.,
RA   Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V.,
RA   Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.;
RT   "Secrets of soil survival revealed by the genome sequence of
RT   Arthrobacter aurescens TC1.";
RL   PLoS Genet. 2:2094-2106(2006).
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC       + N-carbamoyl-L-aspartate.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from HCO(3)(-): step 2/6.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR   EMBL; CP000474; ABM07590.1; -; Genomic_DNA.
DR   RefSeq; YP_948009.1; -.
DR   GeneID; 4638995; -.
DR   GenomeReviews; CP000474_GR; AAur_2269.
DR   KEGG; aau:AAur_2269; -.
DR   TIGR; AAur_2269; -.
DR   OMA; A1R6Z7; RTVVNLF.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00001; -; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P_bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
DR   InterPro; IPR002082; Aspartate_carbamoyltransf_euk.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Pyrimidine biosynthesis; Transferase.
FT   CHAIN         1    335       Aspartate carbamoyltransferase.
FT                                /FTId=PRO_0000301551.
SQ   SEQUENCE   335 AA;  36455 MW;  4A0437E9129C5A11 CRC64;
     MKHLLSTENL SLFDAVRVLD TAEEMSAVGE REVKKLPALR GRTVVNLFFE DSTRTRISFE
     AAAKRLSADV INFAAKGSSV SKGESLKDTA QTLAAMGADA VVIRHWASGA PHRLAATDWI
     DAAVINAGDG THEHPTQALL DAFTMRRHWS QVNGTESTGA DLKGMRVAIA GDVLHSRVAR
     SNVWLLKTLG AEVTLVAPPT LLPIGVEHWP CKVSYNLDET LEAGIDAMMM LRVQGERMNA
     SFFPSTREYS RRWGFDDARL RMLDDLGMKD TIIMHPGPMN RGLEISSAAA DSPRSTVLAQ
     VRNGVSVRMA ALYLLLSGDS REAAPNVSQS SKETN
//