Reviewed, UniProtKB/Swiss-Prot A1R6Z7 (PYRB_ARTAT)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	AAur_2269

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000301551

Sequences

	Sequence		Length	Mass (Da)
	A1R6Z7-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 4A0437E9129C5A11	FASTA	335	36,455
	10 20 30 40 50 60 MKHLLSTENL SLFDAVRVLD TAEEMSAVGE REVKKLPALR GRTVVNLFFE DSTRTRISFE 70 80 90 100 110 120 AAAKRLSADV INFAAKGSSV SKGESLKDTA QTLAAMGADA VVIRHWASGA PHRLAATDWI 130 140 150 160 170 180 DAAVINAGDG THEHPTQALL DAFTMRRHWS QVNGTESTGA DLKGMRVAIA GDVLHSRVAR 190 200 210 220 230 240 SNVWLLKTLG AEVTLVAPPT LLPIGVEHWP CKVSYNLDET LEAGIDAMMM LRVQGERMNA 250 260 270 280 290 300 SFFPSTREYS RRWGFDDARL RMLDDLGMKD TIIMHPGPMN RGLEISSAAA DSPRSTVLAQ 310 320 330 VRNGVSVRMA ALYLLLSGDS REAAPNVSQS SKETN

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000474 Genomic DNA. Translation: ABM07590.1.
RefSeq	YP_948009.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4638995.
GenomeReviews	Gene locus AAur_2269 in contig CP000474_GR.
KEGG	aau:AAur_2269.
TIGR	AAur_2269.
Phylogenomic databases
OMA	A1R6Z7. RTVVNLF.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ARTAT

Accession

Primary (citable) accession number: A1R6Z7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	February 6, 2007
Last modified:	June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)