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Reviewed, UniProtKB/Swiss-Prot A1R6X6 (GLPK_ARTAT)

Last modified November 3, 2009. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glycerol kinase
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase
    Glycerokinase
      Short name=GK
Gene names
Name: glpK
Ordered Locus Names: AAur_2247
OrganismArthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]
Taxonomic identifier290340 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

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Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

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Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

glycerol kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Glycerol kinase HAMAP MF_00186
PRO_1000020696

Regions

Nucleotide binding413 – 4175ATP By similarity

Sites

Binding site121Substrate By similarity
Binding site161ATP By similarity
Binding site821Substrate By similarity
Binding site1341Substrate By similarity
Binding site2461Substrate By similarity
Binding site2681ATP By similarity
Binding site3121ATP; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
A1R6X6-1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 53911CB73D4DB690

FASTA50454,809
        10         20         30         40         50         60 
MNQYVIAIDQ GTTSSRAIVF DHAGNIVSTG QMEHEQIFPQ AGWVEHNPAE IWNNTREVIG 

        70         80         90        100        110        120 
SALSKANLTR HDIAAVGITN QRETAVVWDK NTGEAVYNAI VWQDTRTQSI VDELAQDGGP 

       130        140        150        160        170        180 
ERFKQKVGLP LATYFSGTKI KWILDNVDGA RERAEAGDLL FGNTDAWVLW NLTGGVDGGV 

       190        200        210        220        230        240 
HVTDVTNASR TLFMDLETLQ WDQEILDIFG VPASMMPAIK SSSEVYGHVH TSQLLRETPV 

       250        260        270        280        290        300 
AGILGDQQAA TFGQAAFQPG EAKNTYGTGC FLIFNTGEEI VHSKNGLLTT LGYKLGDAKP 

       310        320        330        340        350        360 
HYALEGSIAV TGSLIQWLRD NLGMISSAPE VEELAAGVRD NGGVYIVPAF SGLFAPYWRA 

       370        380        390        400        410        420 
DARGAIVGLT RFANKGHIAR AALEATAFQT REVLDAVNAD SGVPLTELKV DGGMVANEAL 

       430        440        450        460        470        480 
MQFQADILGV PVVRPKVVET TALGAAYAAG LAVGFWKDLG ELSANWNEDK RWEPQLPAEE 

       490        500 
QERQLRLWKK AVTKSMDWVD EDVK

« Hide

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References

[1]"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1."
Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.
PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000474 Genomic DNA. Translation: ABM08827.1.
RefSeqYP_947988.1.

3D structure databases

SMRA1R6X6. Positions 4-504.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1R6X6.

Genome annotation databases

GeneID4641072.
GenomeReviewsGene locus AAur_2247 in contig CP000474_GR.
KEGGaau:AAur_2247.
TIGRAAur_2247.

Phylogenomic databases

OMALWKKAVT.

Family and domain databases

HAMAPMF_00186.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLPK_ARTAT
AccessionPrimary (citable) accession number: A1R6X6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents