Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Paenarthrobacter aurescens (strain TC1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei610ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAUR290340:G1G7H-2253-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:AAur_2246
OrganismiPaenarthrobacter aurescens (strain TC1)
Taxonomic identifieri290340 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePaenarthrobacter
Proteomesi
  • UP000000637 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347281 – 842Leucine--tRNA ligaseAdd BLAST842

Proteomic databases

PRIDEiA1R6X5

Interactioni

Protein-protein interaction databases

STRINGi290340.AAur_2246

Structurei

3D structure databases

ProteinModelPortaliA1R6X5
SMRiA1R6X5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi62 – 72"HIGH" regionAdd BLAST11
Motifi607 – 611"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A1R6X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKPETETG TAQTAAAEAP EEGVYSFAAM EAKWPQVWED LKVFTPADDG
60 70 80 90 100
SRERRYVLDM FPYPSGDLHM GHAEAFAMGD VVARYLRQKG FDVLHPIGWD
110 120 130 140 150
SFGLPAENAA IKRNAHPSEW TYANIDTQAA SFKRYAISAD WSRRLHTSDP
160 170 180 190 200
EYYRWTQWLF KRFYERGLAY RKDSPVNWCP KDLTVLANEQ VVNGACERCG
210 220 230 240 250
TPVTKKSLNQ WYFKITDYAD RLLEDMDQLQ GHWPERVLAM QRNWIGRSEG
260 270 280 290 300
AHVRFVIEAT ADRAEREVTV FTTRPDTLYG ATFFVVAADA HLALDLVTPE
310 320 330 340 350
QHDELMAYRE KVKALSEIER QSTEREKTGV FTGRYAINPL NGEKLPVWAA
360 370 380 390 400
DYVLADYGTG AIMAVPAHDQ RDLDFAKTFG LPVRAVLDTG DEDPAETGVA
410 420 430 440 450
TAGEGTLKNS GELDGLSKSE GIPAAIEILE KLGTGEKFVN FRLRDWLLSR
460 470 480 490 500
QRFWGTPIPI IHCGECGEVP VPDDQLPVRL PDDLRGEALS PKGTSPLAAA
510 520 530 540 550
VEWVNVECPN CGRAAQRDTD TMDTFVDSSW YFLRFVSPDY TEGPFDPEKI
560 570 580 590 600
NNWMPVGQYV GGVEHAILHL LYARFFTKVI KDIGLIEANE PFSALLNQGQ
610 620 630 640 650
VLNGGKAMSK SLGNGVDLGE QLDKFGVDAV RLTMVFASPP EDDVDWADVS
660 670 680 690 700
PSGSAKFLAR AWRLGQDVSS EPGVDPATGD RALRTVTHKT IADAAELLDN
710 720 730 740 750
NKFNVVVARL MELVNATRKT IDSGAGAADP AVREAVEAVA VILSLFAPYT
760 770 780 790 800
AEDLWNTLGH PASVANAGWP KHDDALLVQD TVTAVVQVQG KVRDRLEVSP
810 820 830 840
DITEDALREL ALASENVQRA LDGRGIRTVI VRAPKLVNIV PA
Length:842
Mass (Da):93,067
Last modified:May 20, 2008 - v2
Checksum:iFF6EE5D4F0C75C80
GO

Sequence cautioni

The sequence ABM09960 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000474 Genomic DNA Translation: ABM09960.1 Different initiation.
RefSeqiWP_043806115.1, NC_008711.1

Genome annotation databases

EnsemblBacteriaiABM09960; ABM09960; AAur_2246
GeneIDi29624253
KEGGiaau:AAur_2246

Similar proteinsi

Entry informationi

Entry nameiSYL_PAEAT
AccessioniPrimary (citable) accession number: A1R6X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health