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A1R6X5

- SYL_ARTAT

UniProt

A1R6X5 - SYL_ARTAT

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Protein
Leucine--tRNA ligase
Gene
leuS, AAur_2246
Organism
Arthrobacter aurescens (strain TC1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei610 – 6101ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAUR290340:GI59-2246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:AAur_2246
OrganismiArthrobacter aurescens (strain TC1)
Taxonomic identifieri290340 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000637: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 842842Leucine--tRNA ligaseUniRule annotation
PRO_0000334728Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290340.AAur_2246.

Structurei

3D structure databases

ProteinModelPortaliA1R6X5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi62 – 7211"HIGH" regionUniRule annotation
Add
BLAST
Motifi607 – 6115"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1R6X5-1 [UniParc]FASTAAdd to Basket

« Hide

MSVKPETETG TAQTAAAEAP EEGVYSFAAM EAKWPQVWED LKVFTPADDG    50
SRERRYVLDM FPYPSGDLHM GHAEAFAMGD VVARYLRQKG FDVLHPIGWD 100
SFGLPAENAA IKRNAHPSEW TYANIDTQAA SFKRYAISAD WSRRLHTSDP 150
EYYRWTQWLF KRFYERGLAY RKDSPVNWCP KDLTVLANEQ VVNGACERCG 200
TPVTKKSLNQ WYFKITDYAD RLLEDMDQLQ GHWPERVLAM QRNWIGRSEG 250
AHVRFVIEAT ADRAEREVTV FTTRPDTLYG ATFFVVAADA HLALDLVTPE 300
QHDELMAYRE KVKALSEIER QSTEREKTGV FTGRYAINPL NGEKLPVWAA 350
DYVLADYGTG AIMAVPAHDQ RDLDFAKTFG LPVRAVLDTG DEDPAETGVA 400
TAGEGTLKNS GELDGLSKSE GIPAAIEILE KLGTGEKFVN FRLRDWLLSR 450
QRFWGTPIPI IHCGECGEVP VPDDQLPVRL PDDLRGEALS PKGTSPLAAA 500
VEWVNVECPN CGRAAQRDTD TMDTFVDSSW YFLRFVSPDY TEGPFDPEKI 550
NNWMPVGQYV GGVEHAILHL LYARFFTKVI KDIGLIEANE PFSALLNQGQ 600
VLNGGKAMSK SLGNGVDLGE QLDKFGVDAV RLTMVFASPP EDDVDWADVS 650
PSGSAKFLAR AWRLGQDVSS EPGVDPATGD RALRTVTHKT IADAAELLDN 700
NKFNVVVARL MELVNATRKT IDSGAGAADP AVREAVEAVA VILSLFAPYT 750
AEDLWNTLGH PASVANAGWP KHDDALLVQD TVTAVVQVQG KVRDRLEVSP 800
DITEDALREL ALASENVQRA LDGRGIRTVI VRAPKLVNIV PA 842
Length:842
Mass (Da):93,067
Last modified:May 20, 2008 - v2
Checksum:iFF6EE5D4F0C75C80
GO

Sequence cautioni

The sequence ABM09960.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000474 Genomic DNA. Translation: ABM09960.1. Different initiation.
RefSeqiYP_947987.1. NC_008711.1.

Genome annotation databases

EnsemblBacteriaiABM09960; ABM09960; AAur_2246.
GeneIDi4641390.
KEGGiaau:AAur_2246.
PATRICi20979912. VBIArtAur67810_2280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000474 Genomic DNA. Translation: ABM09960.1 . Different initiation.
RefSeqi YP_947987.1. NC_008711.1.

3D structure databases

ProteinModelPortali A1R6X5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 290340.AAur_2246.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM09960 ; ABM09960 ; AAur_2246 .
GeneIDi 4641390.
KEGGi aau:AAur_2246.
PATRICi 20979912. VBIArtAur67810_2280.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci AAUR290340:GI59-2246-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TC1.

Entry informationi

Entry nameiSYL_ARTAT
AccessioniPrimary (citable) accession number: A1R6X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi