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A1R6P8

- UPPP_ARTAT

UniProt

A1R6P8 - UPPP_ARTAT

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, AAur_2168
Organism
Arthrobacter aurescens (strain TC1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciAAUR290340:GI59-2168-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:AAur_2168
OrganismiArthrobacter aurescens (strain TC1)
Taxonomic identifieri290340 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000637: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Reviewed prediction
Add
BLAST
Transmembranei157 – 17923Helical; Reviewed prediction
Add
BLAST
Transmembranei191 – 21121Helical; Reviewed prediction
Add
BLAST
Transmembranei227 – 24721Helical; Reviewed prediction
Add
BLAST
Transmembranei255 – 27521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Undecaprenyl-diphosphataseUniRule annotation
PRO_0000290681Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290340.AAur_2168.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A1R6P8-1 [UniParc]FASTAAdd to Basket

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MNWIEAALLG LVQGLTEFLP ISSSAHLRIV GSFLPNAADP GAAFTAITQL    50
GTETAVIVYF WRDIVRIVQA WFGSLTGKVE RNNPDARMGW LVILGSLPII 100
VLGLLFQDQI ESVLRSMWIV ATMLIVFGMI LAVADAVGRQ ERDLTQLSYK 150
HGILYGFAQA MALIPGVSRS GGTITAGLLM GYTREAAARY SFLLAIPAVF 200
GSGLYQLYKT VSNEGLAGPY GLPETALATV IAFVVGYVII GWFLKFVSTR 250
SYRLFVWYRI LLGLALYVLL GFNVISA 277
Length:277
Mass (Da):30,165
Last modified:February 6, 2007 - v1
Checksum:iCC84BD1538D498B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000474 Genomic DNA. Translation: ABM09871.1.
RefSeqiYP_947910.1. NC_008711.1.

Genome annotation databases

EnsemblBacteriaiABM09871; ABM09871; AAur_2168.
GeneIDi4639972.
KEGGiaau:AAur_2168.
PATRICi20979750. VBIArtAur67810_2199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000474 Genomic DNA. Translation: ABM09871.1 .
RefSeqi YP_947910.1. NC_008711.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 290340.AAur_2168.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM09871 ; ABM09871 ; AAur_2168 .
GeneIDi 4639972.
KEGGi aau:AAur_2168.
PATRICi 20979750. VBIArtAur67810_2199.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci AAUR290340:GI59-2168-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TC1.

Entry informationi

Entry nameiUPPP_ARTAT
AccessioniPrimary (citable) accession number: A1R6P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi