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Protein

Glucose-1-phosphate adenylyltransferase

Gene

glgC

Organism
Paenarthrobacter aurescens (strain TC1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.UniRule annotation

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.UniRule annotation

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei165Alpha-D-glucose 1-phosphate; via amide nitrogenUniRule annotation1
Binding sitei200Alpha-D-glucose 1-phosphate; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00164.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferaseUniRule annotation (EC:2.7.7.27UniRule annotation)
Alternative name(s):
ADP-glucose pyrophosphorylaseUniRule annotation
Short name:
ADPGlc PPaseUniRule annotation
ADP-glucose synthaseUniRule annotation
Gene namesi
Name:glgCUniRule annotation
Ordered Locus Names:AAur_2136
OrganismiPaenarthrobacter aurescens (strain TC1)
Taxonomic identifieri290340 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePaenarthrobacter
Proteomesi
  • UP000000637 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000515561 – 470Glucose-1-phosphate adenylyltransferaseAdd BLAST470

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi290340.AAur_2136.

Structurei

3D structure databases

ProteinModelPortaliA1R6L8.
SMRiA1R6L8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni182 – 183Alpha-D-glucose 1-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QQ4. Bacteria.
COG0448. LUCA.
HOGENOMiHOG000278607.
KOiK00975.
OMAiHCVLGVR.
OrthoDBiPOG091H09L2.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00624. GlgC. 1 hit.
InterProiView protein in InterPro
IPR005836. ADP_Glu_pyroP_CS.
IPR011831. GlgC.
IPR023049. GlgC_bac.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
PfamiView protein in Pfam
PF00483. NTP_transferase. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
TIGRFAMsiTIGR02091. glgC. 1 hit.
PROSITEiView protein in PROSITE
PS00809. ADP_GLC_PYROPHOSPH_2. 1 hit.
PS00810. ADP_GLC_PYROPHOSPH_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A1R6L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMALKKVLA IVLAGGEGNR LMPLTADRAK PAVPFAGGYR LIDFALSNLV
60 70 80 90 100
NSGYLKIVVL TQYKSHSLDR HISETWRMST QLGRYVASVP AQQRVGKSWF
110 120 130 140 150
LGSANAIYQS LNLIHDDAPD IVVVVGADHV YRMDFSQMVE QHIASGAKAT
160 170 180 190 200
VAAVRQPLNM ANQFGVIEVD QNDPQKIAAF VEKPASTPGL AADPTQFLAS
210 220 230 240 250
MGNYVFNADA LVEALHVDAE RLDTKHDMGG DIIPYFVDQG EAGVYDFTLN
260 270 280 290 300
DIPGATERDR TYWRDVGTID SFYDAHMDLI SPVPIFNLYN SEWPIYTRQS
310 320 330 340 350
ISPPAKFVRG ENNTVGTALD SIVASGVVVS GGIVEGSVLS NDAYVAAGSR
360 370 380 390 400
VQDSVLMDKV RVGEGAVIKR AILDKNVKVP AGAAIGLDPA LDKARGYKVT
410 420 430 440 450
ESGITVLAKG QVVPEPGEAE LALSAQHRRG LPEAVKAATH DDPDIRDSAE
460 470
KVAAGIQSRV ADAAAQGAAH
Length:470
Mass (Da):50,290
Last modified:February 6, 2007 - v1
Checksum:iB98613224E89306F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000474 Genomic DNA. Translation: ABM08641.1.

Genome annotation databases

EnsemblBacteriaiABM08641; ABM08641; AAur_2136.
KEGGiaau:AAur_2136.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGLGC_PAEAT
AccessioniPrimary (citable) accession number: A1R6L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: June 7, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families