A1R6D9 (A1R6D9_ARTAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800

Gene names

Ordered Locus Names:

AAur_2057

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP] EMBL ABM09879.1

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800
Catalytic activity	L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800
Cofactor	Pyridoxal phosphate By similarity. PIRNR PIRNR038800
Pathway	Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800
Subunit structure	Homodimer By similarity. PIRNR PIRNR038800
Sequence similarities	Belongs to the kynureninase family. PIRNR PIRNR038800

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis PIRNR PIRNR038800
Ligand	Pyridoxal phosphate PIRNR PIRNR038800
Molecular function	Hydrolase PIRNR PIRNR038800
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro tryptophan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	kynureninase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1R6D9 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 7EE4F433FCE8F3E8	FASTA	412	44,406
	10 20 30 40 50 60 MTTAQQTQRP TSAELDAADP LAAQRDAFYT PDADQLVSYL DGNSLGRPLK VTSANLASFV 70 80 90 100 110 120 HDAWGSRLIR GWDEQWMDDP TVVGDRIGEV ALGAAPGQTT VGDSTSVMLY KMIRAAVDAQ 130 140 150 160 170 180 PGRDEIIIDR DNFPTDRFII EGIAKERGAN IKWIAANPAS GVCAEDLDGL LGERTAVVVL 190 200 210 220 230 240 SHVAYRSGFL ADAKGITAKV HQAGALMLWD LCHSVGSVPL QLDEWGVDLA VGCTYKYLNG 250 260 270 280 290 300 GPGSPAFAYV NASQQDRLQQ PIWGWMGADN PFGMTESYKP AQGMRRFITG TPPVLAMQPL 310 320 330 340 350 360 KDMVELIATV GMDAVREKSI KLTEYAIALS EELLVPLGAE IVSPRNPAQR GSHITVDHTL 370 380 390 400 410 FADVTAKLWE KGVIPDFRPP HGLRIGLSPL STSFAEVEVG VAAIRDALSE LL

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000474 Genomic DNA. Translation: ABM09879.1.
RefSeq	YP_947801.1. NC_008711.1.
3D structure databases
ProteinModelPortal	A1R6D9.
ModBase	Search...
Protein-protein interaction databases
STRING	A1R6D9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4637698.
GenomeReviews	Gene locus AAur_2057 in contig CP000474_GR.
KEGG	aau:AAur_2057.
PATRIC	20979522. VBIArtAur67810_2086.
TIGR	AAur_2057.
Phylogenomic databases
eggNOG	COG3844.
HOGENOM	HBG523016.
OMA	GSPAFAY.
ProtClustDB	CLSK956672.
Family and domain databases
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR010111. Kynureninase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K01556.
PANTHER	PTHR14084. Kynureninase. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
PIRSF	PIRSF038800. KYNU. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1R6D9_ARTAT

Accession

Primary (citable) accession number: A1R6D9

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)