A1R674 (IOLG2_ARTAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase 2
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase 2
Short name=MI 2-dehydrogenase 2

Gene names

Name:	iolG2
Ordered Locus Names:	AAur_1991

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Inositol 2-dehydrogenase 2 HAMAP MF_01671		PRO_0000352552

Sequences

	Sequence		Length	Mass (Da)
	A1R674 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: D86D3F17C1AF5CB7	FASTA	332	34,727
	10 20 30 40 50 60 MPIRVGVIGA GVMGADHIRN LSTTIGGAKV TFVADLDAGR AAAAAPPSAR ITTDPTELIN 70 80 90 100 110 120 SSDVDAVVVA SHDSTHAGLV LECFEAMTPV LCEKPLAPTL LESLEVVAAD ADIVAATGAS 130 140 150 160 170 180 LLSLGFMRRF DPGYVALRQA VQGRVQGEPL MVHCVSRNAA AGPGTTSELA ITNSAIHELD 190 200 210 220 230 240 IIPWLLGSPV TEVSWQAGKQ TSRAEPGLQD PSFMTLRTAD GTLTTLELYL NAQYGYTTRC 250 260 270 280 290 300 EVVSEQGTTS LQESSLLGIE QDGTRQAVIP ADWRPRFADA YRLQLQAWIS ALAGGEAPSL 310 320 330 AGAQDGLNAS LVAQAMIQSL HSDGTTTKVS YS

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000474 Genomic DNA. Translation: ABM08382.1.
RefSeq	YP_947736.1. NC_008711.1.
3D structure databases
ProteinModelPortal	A1R674.
ModBase	Search...
Protein-protein interaction databases
STRING	A1R674.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4639703.
GenomeReviews	Gene locus AAur_1991 in contig CP000474_GR.
KEGG	aau:AAur_1991.
PATRIC	20979382. VBIArtAur67810_2016.
TIGR	AAur_1991.
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
OMA	SHDSTHA.
ProtClustDB	CLSK2471078.
Enzyme and pathway databases
BioCyc	AAUR290340:AAUR_1991-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG2_ARTAT

Accession

Primary (citable) accession number: A1R674

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program