A1R5S7 (TRPC_ARTAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	AAur_1838

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000018431

Sequences

	Sequence		Length	Mass (Da)
	A1R5S7 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: B0A2F912F4489D92	FASTA	272	28,674
	10 20 30 40 50 60 MTVLDDIIVG VKEDMEVRRG LVSLAELKER AANAAPARDA WAALGGPSSI RNDLKVIAEI 70 80 90 100 110 120 KRRSPSKGDL ASIADPASLA VQYADGGASV ISVLTEQRRF GGSLADFDAV RAAVETPLLR 130 140 150 160 170 180 KDFTVDEYQI WEARAHGADL ILLIVAALSD AELADFSALS HELGMNVLVE THTEEEIERA 190 200 210 220 230 240 VAAQAKIIGI NVRNLKTLDV DRSVFGSLAG LIPAESVIVA ESGVRGPEDV SHYAAGGANA 250 260 270 ILVGEALVSD STPRERITEF KAAGAAAIAV RN

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000474 Genomic DNA. Translation: ABM09959.1.
RefSeq	YP_947589.1. NC_008711.1.
3D structure databases
ProteinModelPortal	A1R5S7.
ModBase	Search...
Protein-protein interaction databases
STRING	A1R5S7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4637629.
GenomeReviews	Gene locus AAur_1838 in contig CP000474_GR.
KEGG	aau:AAur_1838.
PATRIC	20979074. VBIArtAur67810_1863.
TIGR	AAur_1838.
Phylogenomic databases
eggNOG	COG0134.
HOGENOM	HBG540956.
OMA	VESLGMT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	AAUR290340:AAUR_1838-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_ARTAT

Accession

Primary (citable) accession number: A1R5S7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program