A1R5N7 (DXS_ARTAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	AAur_1790

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	657 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 657	657	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_1000019005

Sequences

	Sequence		Length	Mass (Da)
	A1R5N7 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 55288974525E2AE0	FASTA	657	70,553
	10 20 30 40 50 60 MGLLETVKDP RDLAKLSGTE LEQLAGEIRE FLITNVAATG GHLGPNLGVV ELTLAVHRNF 70 80 90 100 110 120 DSPRDSIVFD TGHQSYVHKL LTGRQDFTTL RQQGGLSGYP DRAESEHDIV ESSHASSSLS 130 140 150 160 170 180 WADGISRARQ LTGEGDRFVV AVVGDGALTG GMAWEAINNI AADKRRRVVI VVNDNGRSYA 190 200 210 220 230 240 PTVGGFADYL ASLRPTIDSL RTTPAYERML DWWKKKLQDG GPAGQFTYKS LHAMKKGIKD 250 260 270 280 290 300 WWAPQGMFED LGMKYIGPVD GHNLQAMEHA LNTAKAYGGP VIVHAMTEKG HGYAPALANE 310 320 330 340 350 360 ADQFHAVGII DPETGEPTEM SGARSWTSVF AEEIADIADE RSDIVGITGA MLIPVGLHKF 370 380 390 400 410 420 AERHPERVID VGIAEQHALT SAAGMAFGGL HPVVAVYATF LNRAFDQLLM DVALHKAGVT 430 440 450 460 470 480 IVLDRAGVTG PDGPSHHGMW DMAMVQIVPG LHLAAPRDAT RLREELREAV AINDAPTVVR 490 500 510 520 530 540 FSKGSVGSEI EAIDRLHDGV DILARRPDGS TENDVLIVSV GAMSELALDV ATRLGAQGIS 550 560 570 580 590 600 STVVDPRWVL PVRKSIIALA ARHRLVICIE DGVRAGGVGS RIRQEMRAAG VDTALNEVGL 610 620 630 640 650 PVEFLVHGSR SQVLERVGLT AQKITHDVVA QVLGTKVPFA RPLPGQEHPT TGSLPTL

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000474 Genomic DNA. Translation: ABM09947.1.
RefSeq	YP_947549.1. NC_008711.1.
3D structure databases
ProteinModelPortal	A1R5N7.
ModBase	Search...
Protein-protein interaction databases
STRING	A1R5N7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4639914.
GenomeReviews	Gene locus AAur_1790 in contig CP000474_GR.
KEGG	aau:AAur_1790.
PATRIC	20978976. VBIArtAur67810_1821.
TIGR	AAur_1790.
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	QYDISYM.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	AAUR290340:AAUR_1790-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_ARTAT

Accession

Primary (citable) accession number: A1R5N7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program