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A1R5F9 (MURC_ARTAT) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene names
Name:murC
Ordered Locus Names:AAur_1711
OrganismArthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]
Taxonomic identifier290340 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00046

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046

Subcellular location

Cytoplasm By similarity HAMAP MF_00046.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046
PRO_0000336812

Regions

Nucleotide binding118 – 1247ATP Potential

Sequences

Sequence LengthMass (Da)Tools
A1R5F9 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 8299FE2E23C22040

FASTA45646,580
        10         20         30         40         50         60 
MTTSIAGLES LGRVHFIGIG GVGMSAVARI MVSRGVPVSG SDVKDLPVMR DLSSAGARIA 

        70         80         90        100        110        120 
VGYDAGNLGD AQTIVAGSAI RADNPELVAA REAGLPVLHR SEALAATMAG HRVVTVAGTH 

       130        140        150        160        170        180 
GKSTTTSMVA VLLKEAGLDP SFAIGANVPA LGVNAAHGSS DIFVAEADES DGSFLNYRPL 

       190        200        210        220        230        240 
IAVVTNVEAD HLDHYGTPEA VFASFDDFAA LLPAQGVLLA CSDDAGARAL ADRTASKGTT 

       250        260        270        280        290        300 
RVLTYGTSDD ADIRLHDGGP GDVSVALDGG VHKLELQVPG RHNALNAAAA FAVAVELGVE 

       310        320        330        340        350        360 
PGAAAAALGH FTGASRRFEL KGRGRGVRVY DDYAHHPTEV RAALSAARSV AGDNKVHVLF 

       370        380        390        400        410        420 
QPHLFSRTRE FSQEFAAALD LADTALVLDI YPAREDPIPG VTSTLITDHL VNGRLVSADE 

       430        440        450 
AVDAVAAVAS EGDVVLTVGA GDVTAYGPVI VEALGG

« Hide

References

[1]"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1."
Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.
PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TC1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000474 Genomic DNA. Translation: ABM09686.1.
RefSeqYP_947471.1. NC_008711.1.

3D structure databases

ProteinModelPortalA1R5F9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1R5F9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4640378.
GenomeReviewsGene locus AAur_1711 in contig CP000474_GR.
KEGGaau:AAur_1711.
PATRIC20978820. VBIArtAur67810_1743.
TIGRAAur_1711.

Phylogenomic databases

eggNOGCOG0773.
HOGENOMHBG476594.
OMAYQPHRYS.
ProtClustDBPRK00421.

Enzyme and pathway databases

BioCycAAUR290340:AAUR_1711-MONOMER.

Family and domain databases

HAMAPMF_00046. MurC.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01924.
PANTHERPTHR23135:SF5. PTHR23135:SF5. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01082. MurC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURC_ARTAT
AccessionPrimary (citable) accession number: A1R5F9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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