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A1R5F5 (MRAY_ARTAT) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:AAur_1707
OrganismArthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]
Taxonomic identifier290340 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000002934

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane55 – 7521Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane239 – 25921Helical; Potential
Transmembrane266 – 28621Helical; Potential
Transmembrane291 – 31121Helical; Potential
Transmembrane348 – 36821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1R5F5 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: E794427334C822EB

FASTA36939,264
        10         20         30         40         50         60 
MIALLIGAGV ALLVALIGTP LFIRFLVAKS YGQFIRDDGP TSHHTKRGTP TMGGTVVVAA 

        70         80         90        100        110        120 
VLISYFVTHL IMWMMNPDSA GPSASGLLLL FLMVGMGFVG FLDDFIKISN KRSLGLNARA 

       130        140        150        160        170        180 
KLILQAAVGI IFAVLVLQFP NEDGLRPAST QISLVRDIPW LDLAFGGTVV GAILFVLWSN 

       190        200        210        220        230        240 
LIITAATNGV NLTDGLDGLA AGASIMVFGA YTIMGIWQNN QACGSPREAG SGCYQVRDPM 

       250        260        270        280        290        300 
DLALLAAILS AALVGFLWWN TSPAKIFMGD TGSLAIGGAV AAFAILSRTE LLLAFIGGLF 

       310        320        330        340        350        360 
VLITLSVIIQ VGFFKLSGGK RVFKMAPLQH HFELKGWDEV TVVVRFWILA GLFVAAGLGI 


FYAEWVVLL

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References

[1]"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1."
Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.
PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TC1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000474 Genomic DNA. Translation: ABM07466.1.
RefSeqYP_947467.1. NC_008711.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA1R5F5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4638057.
GenomeReviewsGene locus AAur_1707 in contig CP000474_GR.
KEGGaau:AAur_1707.
PATRIC20978812. VBIArtAur67810_1739.
TIGRAAur_1707.

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHBG708263.
OMAAGGLMFY.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycAAUR290340:AAUR_1707-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. False negative.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ARTAT
AccessionPrimary (citable) accession number: A1R5F5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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