A1R5F4 (A1R5F4_ARTAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136
EC=6.3.2.10 RuleBase RU004136

Gene names

Name:	murF EMBL ABM07014.1
Ordered Locus Names:	AAur_1706 EMBL ABM07014.1

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP] EMBL ABM07014.1

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter › Arthrobacter aurescens

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity. RuleBase RU004136
Catalytic activity	ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine. RuleBase RU004136
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. RuleBase RU004136
Subcellular location	Cytoplasm By similarity RuleBase RU004136.
Sequence similarities	Belongs to the MurCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division RuleBase RU004136 Cell shape Cell wall biogenesis/degradation RuleBase RU004136 Peptidoglycan synthesis RuleBase RU004136
Ligand	ATP-binding RuleBase RU003630 Nucleotide-binding
Molecular function	Ligase RuleBase RU003630 EMBL ABM07014.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Inferred from electronic annotation. Source: EC UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1R5F4 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 5F4221266448998A	FASTA	496	51,839
	10 20 30 40 50 60 MIALTAAEIA DITHGRLTGD PDIVPTSVVT DSRESTHGSL YVAKPGEHAD GHDFVDAAFE 70 80 90 100 110 120 RGAVLVLGER EVTDADGRPF PAVVVEDAVL AMGALAAESV RRIRAERASR GEDFTVIGIT 130 140 150 160 170 180 GSAGKTTTKD LLAGVLSTAG ATVAPQGSYN GEVGVPLTVF AADATTRFLV IEMGATGLGH 190 200 210 220 230 240 IKYLAEMVKP DIGVVLVVGT AHAGEFGGVE NIAKTKGELV EALSEHGTAV INLDDGRVAA 250 260 270 280 290 300 MRARTKAKVL GFTSSPATTE EVEARNVVVN GQGFPDFDLV LPDGGPAVEV RSRLIGGHHV 310 320 330 340 350 360 TNLLAAAAAA FAAGIPAADI ATSLSSQSAA SRWRMERTER ADGVTIINDA YNANPESMRA 370 380 390 400 410 420 ALRSLADLGQ GRRTWAVLGA MLELGEDSIR EHTAVGTQVV RLNISRLVVV GREARALYIS 430 440 450 460 470 480 AIQEGSWGDE CSFTETVEEA YELLQRELEP GDLVLFKSSN GVGLRHLGDR IALPPRAEPT 490 GENAAEAAAS EGNELL

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartsbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:e214-e214(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TC1 EMBL ABM07014.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000474 Genomic DNA. Translation: ABM07014.1.
RefSeq	YP_947466.1. NC_008711.1.
3D structure databases
ProteinModelPortal	A1R5F4.
ModBase	Search...
Protein-protein interaction databases
STRING	290340.AAur_1706.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABM07014; ABM07014; AAur_1706.
GeneID	4637623.
KEGG	aau:AAur_1706.
PATRIC	20978810. VBIArtAur67810_1738.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0770.
HOGENOM	HOG000268120.
KO	K01929.
OMA	CINLALF.
ProtClustDB	CLSK959754.
Enzyme and pathway databases
BioCyc	AAUR290340:GI59-2317-MONOMER.
UniPathway	UPA00219.
Family and domain databases
Gene3D	3.40.1190.10. 1 hit. 3.90.190.20. 1 hit.
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR005863. UDP-N-AcMur-pentapeptide_synth. [Graphical view]
PANTHER	PTHR23135:SF3. PTHR23135:SF3. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
SUPFAM	SSF53244. Mur_ligase_C. 1 hit. SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMs	TIGR01143. murF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1R5F4_ARTAT

Accession

Primary (citable) accession number: A1R5F4

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)