Reviewed, UniProtKB/Swiss-Prot A1R587 (ARGB_ARTAT)

Names and origin

Protein names

Recommended name:
    Acetylglutamate kinase
    EC=2.7.2.8
Alternative name(s):
    NAG kinase
      Short name=AGK
    N-acetyl-L-glutamate 5-phosphotransferase

Gene names

Name:	argB
Ordered Locus Names:	AAur_1633

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Acetylglutamate kinase HAMAP MF_00082		PRO_0000335606
Regions
	Region	76 – 77	2	Substrate binding By similarity
Sites
	Binding site	98	1	Substrate By similarity
	Binding site	207	1	Substrate By similarity
	Site	41	1	Transition state stabilizer By similarity
	Site	268	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1R587-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 8500DD1721972936	FASTA	316	33,110
	10 20 30 40 50 60 MTMTAHTRET TSMSDAQDKA GTLIEALPWI QRFAGTTMVI KYGGNAMVND DLRRAFAEDI 70 80 90 100 110 120 VFLHHVGIHP VVVHGGGPQI NSMLSRLGIE SEFKGGLRVT TPEAMDVVRM VLTGQVGREL 130 140 150 160 170 180 VGLINSHGPY AVGMSGEDGG LLRAVRTGTV VDGEEVDLGL VGEVVGVDPA GIKDILDAGR 190 200 210 220 230 240 IPVISTVAPE ILDDGNGSGP TTGQVLNVNA DTAAAAVASA LGATKLVILT DVEGLYANWP 250 260 270 280 290 300 DKSSLISSLT ASELRDMLPR LESGMIPKMA ACLKAIDEGV ERAHIVDGRL PHSMLLETFT 310 TAGIGTQVVP DEEVNA

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000474 Genomic DNA. Translation: ABM07296.1.
RefSeq	YP_947399.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1R587.
Genome annotation databases
GeneID	4637438.
GenomeReviews	Gene locus AAur_1633 in contig CP000474_GR.
KEGG	aau:AAur_1633.
TIGR	AAur_1633.
Phylogenomic databases
OMA	FVIKYGG.
Family and domain databases
HAMAP	MF_00082. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR011148. GlcNAc_kinase. IPR001057. Glu_5kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ARTAT

Accession

Primary (citable) accession number: A1R587

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)