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A1R585 (ARGC_ARTAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase
Gene names
Name:argC
Ordered Locus Names:AAur_1631
OrganismArthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]
Taxonomic identifier290340 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter ›

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP-Rule MF_00150

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP-Rule MF_00150

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionN-acetyl-gamma-glutamyl-phosphate reductase activity

Inferred from electronic annotation. Source: HAMAP

NAD binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343N-acetyl-gamma-glutamyl-phosphate reductase HAMAP-Rule MF_00150
PRO_1000010974

Sites

Active site1461 By similarity

Sequences

Sequence LengthMass (Da)Tools
A1R585 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 9A5BA263C290E354

FASTA34335,120
        10         20         30         40         50         60 
MTISVAVSGA SGYAGGEVLR LLAGHPNVTI GAITAHSNAG SRLGELQPHL HGLASRILED 

        70         80         90        100        110        120 
TTVENLSGHD VVFLALPHGA SAEIAAQLPE GTVVIDAGAD HRLQDAAAWE RFYGSAHAGT 

       130        140        150        160        170        180 
WPYGLPELPG QREALKGATR IAVPGCYPTS ALLALTPGFA NNLLLTDDVV IVSASGTSGA 

       190        200        210        220        230        240 
GKAAKVNLIG AEVMGSMSPY GVGGGHRHTP EIEQGLSNAA GEPVTVSFTP TLVPMSRGIL 

       250        260        270        280        290        300 
TTATAKVGHG VSYAELRQAW ADAYDDEPFV HLLPEGQWPT TKSVQGSNHA VMQLAFDAHT 

       310        320        330        340 
GRVIVTCAID NLTKGTAGGA VQSMNIALGL DETAGLNLQG VAP

« Hide

References

[1]"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1."
Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.
PLoS Genet. 2:2094-2106(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TC1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000474 Genomic DNA. Translation: ABM10170.1.
RefSeqYP_947397.1. NC_008711.1.

3D structure databases

ProteinModelPortalA1R585.
SMRA1R585. Positions 3-343.
ModBaseSearch...

Protein-protein interaction databases

STRING290340.AAur_1631.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM10170; ABM10170; AAur_1631.
GeneID4641044.
KEGGaau:AAur_1631.
PATRIC20978656. VBIArtAur67810_1665.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0002.
HOGENOMHOG000254904.
KOK00145.
OMAKHAGSWP.
ProtClustDBPRK00436.

Enzyme and pathway databases

BioCycAAUR290340:GI59-2246-MONOMER.
UniPathwayUPA00068; UER00108.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00150. ArgC_type1.
InterProIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01850. argC. 1 hit.
PROSITEPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGC_ARTAT
AccessionPrimary (citable) accession number: A1R585
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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