A1R4S6 (HUTI_ARTAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Imidazolonepropionase
EC=3.5.2.7

Alternative name(s):
Imidazolone-5-propionate hydrolase

Gene names

Name:	hutI
Ordered Locus Names:	AAur_1464

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372
Subcellular location	Cytoplasm Potential HAMAP MF_00372.
Sequence similarities	Belongs to the HutI family.

Ontologies

Keywords
Biological process	Histidine metabolism
Cellular component	Cytoplasm
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine catabolic process to glutamate and formamide Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	imidazolonepropionase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 409	409	Imidazolonepropionase HAMAP MF_00372		PRO_0000306425
Sites
	Metal binding	70	1	Zinc or iron By similarity
	Metal binding	72	1	Zinc or iron By similarity
	Metal binding	225	1	Zinc or iron By similarity
	Metal binding	312	1	Zinc or iron By similarity
	Binding site	79	1	Substrate By similarity
	Binding site	92	1	Substrate By similarity
	Binding site	137	1	Substrate By similarity
	Binding site	164	1	Substrate By similarity
	Binding site	228	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1R4S6 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 0E5E2C6F86B6216F	FASTA	409	42,887
	10 20 30 40 50 60 MSATNSASTL ITNIGELMTQ DMEHRVLKDA AIVIEGERIA WLGSTKDAPA ADENIDAQGR 70 80 90 100 110 120 AVLPGWVDSH SHLVFAGDRT AEFEARMAGE SYSAGGIAVT TGATRSVSDD ELTRLVRDRV 130 140 150 160 170 180 AEAVSQGTTY LESKTGYGLD VENEARSARI AAAEVDEVTY LGAHLVPDGS DPEEYTDLVC 190 200 210 220 230 240 GPMLDAVLPH VRWADVFCER GAFTEDQSRR VLRAARDAGL GLRVHGNQLG EGPGVALAVE 250 260 270 280 290 300 FAAASVDHVN YLSDKDVLAL AGTWAGWDPA TGAGTKGTVA TCLPACDLST RQPLAPGREL 310 320 330 340 350 360 IDAGVQIALA ANCNPGTSYT SSMAFCVTTA VLQMHLSVHE AVRAATYGGA LALGRESGND 370 380 390 400 VDGERAVGSL AVGHRADLHM LKAPSATHLA YRPGIPLTGS VWRAGVRVV

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000474 Genomic DNA. Translation: ABM06836.1.
RefSeq	YP_947238.1. NC_008711.1.
3D structure databases
ProteinModelPortal	A1R4S6.
ModBase	Search...
Protein-protein interaction databases
STRING	A1R4S6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4638746.
GenomeReviews	Gene locus AAur_1464 in contig CP000474_GR.
KEGG	aau:AAur_1464.
PATRIC	20978308. VBIArtAur67810_1494.
TIGR	AAur_1464.
Phylogenomic databases
eggNOG	COG1228.
HOGENOM	HBG686142.
OMA	MNMACTL.
ProtClustDB	PRK14085.
Enzyme and pathway databases
BioCyc	AAUR290340:AAUR_1464-MONOMER.
Family and domain databases
HAMAP	MF_00372. HutI. [Tree]
InterPro	IPR005920. HutI. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01468.
PANTHER	PTHR22642. PTHR22642. 1 hit.
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR01224. HutI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HUTI_ARTAT

Accession

Primary (citable) accession number: A1R4S6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program