Reviewed,
UniProtKB/Swiss-Prot A1R4F8 (ISPE_ARTAT)
Last modified
February 9, 2010.
Version 28.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase Short name=CMK EC=2.7.1.148 Alternative name(s): 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase | ||||
| Gene names |
| ||||
| Organism | Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 290340 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter |
Protein attributes
| Sequence length | 317 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP MF_00061 |
| Catalytic activity | ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00061 |
| Pathway | Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP MF_00061 |
| Sequence similarities | Belongs to the GHMP kinase family. IspE subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Isoprene biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | phosphorylation Inferred from electronic annotation. Source: InterPro terpenoid biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Inferred from electronic annotation. Source: HAMAP ATP bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 317 | 317 | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP MF_00061 | PRO_0000335698 | |||||
Regions | |||||||||
| Nucleotide binding | 109 – 119 | 11 | ATP Potential | ||||||
Sites | |||||||||
| Active site | 17 | 1 | By similarity | ||||||
| Active site | 151 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000474 Genomic DNA. Translation: ABM06709.1. |
| RefSeq | YP_947120.1. |
3D structure databases | |
| SMR | A1R4F8. Positions 10-294. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A1R4F8. |
Genome annotation databases | |
| GeneID | 4638199. |
| GenomeReviews | Gene locus AAur_1338 in contig CP000474_GR. |
| KEGG | aau:AAur_1338. |
| TIGR | AAur_1338. |
Phylogenomic databases | |
| eggNOG | COG1947. |
| HOGENOM | HBG734593. |
| OMA | GVHLEIT. |
Family and domain databases | |
| HAMAP | MF_00061. IspE. [Tree] |
| InterPro | IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR004424. IspE. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view] |
| Gene3D | G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. |
| PANTHER | PTHR20861:SF2. IspE. 1 hit. |
| Pfam | PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF010376. IspE. 1 hit. |
| TIGRFAMs | TIGR00154. ispE. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ISPE_ARTAT | ||||||||
| Accession | Primary (citable) accession number: A1R4F8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


