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A1R317

- PCKG_ARTAT

UniProt

A1R317 - PCKG_ARTAT

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Arthrobacter aurescens (strain TC1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei82 – 821SubstrateUniRule annotation
    Binding sitei224 – 2241Substrate; via amide nitrogenUniRule annotation
    Metal bindingi231 – 2311ManganeseUniRule annotation
    Binding sitei231 – 2311SubstrateUniRule annotation
    Metal bindingi251 – 2511Manganese; via tele nitrogenUniRule annotation
    Binding sitei273 – 2731SubstrateUniRule annotation
    Active sitei275 – 2751UniRule annotation
    Metal bindingi298 – 2981ManganeseUniRule annotation
    Binding sitei391 – 3911GTPUniRule annotation
    Binding sitei422 – 4221GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi274 – 2796GTPUniRule annotation
    Nucleotide bindingi517 – 5204GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAAUR290340:GI59-832-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:AAur_0832
    OrganismiArthrobacter aurescens (strain TC1)
    Taxonomic identifieri290340 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
    ProteomesiUP000000637: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 608608Phosphoenolpyruvate carboxykinase [GTP]PRO_1000072369Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi290340.AAur_0832.

    Structurei

    3D structure databases

    ProteinModelPortaliA1R317.
    SMRiA1R317. Positions 13-608.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni389 – 3913Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiWDNPAGV.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1R317-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDLARLPLL EKAPTTHARL LAWVEEVAEL TQPDRIHWVD GSEAENKKLT    50
    DELVEAGTLK RLNPETFPNS FAAFSDPADV ARVEEQTFIC SENERDAGFT 100
    NNWMAPAEMK QKLRGLFAGS MRGRTMYVIP FVMGHLDAED PKFGVEITDS 150
    AYVVASMRIM ARIGTDVLDR ITQTDAFFVP ALHSLGAPLE AGQADVAWPC 200
    NTDKWIVHFP EERSIWSFGS GYGGNALLGK KCYALRIASV MARDEGWLAE 250
    HMLILKLTSP EQKTYYISAA FPSACGKTNL ALLDPTIKGW KVETLGDDIT 300
    WMRFGKEGEL RAVNPEAGLF GVAPGTGWGT NPNAMRAIAK GNSIFTNVAL 350
    TDDGGVWWEG MTEETPAHLT DWRGESWTPD SDAPAAHPNS RFCTPIDQID 400
    MLAEEYFSPE GVELSAILFG GRRKTTIPLV TEARNWSNGI FMGSTLSSET 450
    TAAAAGAVGV VRRDPMAMLP FIGYDAGDYL NHWVNLSAKA NPERLPKIFL 500
    VNWFRRTAEG GFAWPGFGDN ARVLKWAIER LEGKADAVET PIGFVPTGES 550
    IDLEGLDMTP AEVESAVRVD PAEWATELAS IEEWFANFGE SLPAALQSEL 600
    DGLKTRLG 608
    Length:608
    Mass (Da):66,672
    Last modified:February 6, 2007 - v1
    Checksum:i8CD348EF6CF1A564
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000474 Genomic DNA. Translation: ABM06961.1.
    RefSeqiYP_946629.1. NC_008711.1.

    Genome annotation databases

    EnsemblBacteriaiABM06961; ABM06961; AAur_0832.
    GeneIDi4641427.
    KEGGiaau:AAur_0832.
    PATRICi20976990. VBIArtAur67810_0845.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000474 Genomic DNA. Translation: ABM06961.1 .
    RefSeqi YP_946629.1. NC_008711.1.

    3D structure databases

    ProteinModelPortali A1R317.
    SMRi A1R317. Positions 13-608.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290340.AAur_0832.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM06961 ; ABM06961 ; AAur_0832 .
    GeneIDi 4641427.
    KEGGi aau:AAur_0832.
    PATRICi 20976990. VBIArtAur67810_0845.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi WDNPAGV.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci AAUR290340:GI59-832-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TC1.

    Entry informationi

    Entry nameiPCKG_ARTAT
    AccessioniPrimary (citable) accession number: A1R317
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3