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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Paenarthrobacter aurescens (strain TC1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82SubstrateUniRule annotation1
Metal bindingi231ManganeseUniRule annotation1
Metal bindingi251Manganese; via tele nitrogenUniRule annotation1
Binding sitei273SubstrateUniRule annotation1
Active sitei275UniRule annotation1
Metal bindingi298ManganeseUniRule annotation1
Binding sitei391GTPUniRule annotation1
Binding sitei422GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi274 – 279GTPUniRule annotation6
Nucleotide bindingi517 – 520GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processGluconeogenesis
LigandGTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:AAur_0832
OrganismiPaenarthrobacter aurescens (strain TC1)
Taxonomic identifieri290340 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePaenarthrobacter
Proteomesi
  • UP000000637 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000723691 – 608Phosphoenolpyruvate carboxykinase [GTP]Add BLAST608

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi290340.AAur_0832

Structurei

3D structure databases

ProteinModelPortaliA1R317
SMRiA1R317
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni222 – 224Substrate bindingUniRule annotation3
Regioni389 – 391Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C0M Bacteria
COG1274 LUCA
HOGENOMiHOG000191700
KOiK01596
OMAiCWLALTD
OrthoDBiPOG091H0B4F

Family and domain databases

CDDicd00819 PEPCK_GTP, 1 hit
Gene3Di3.40.449.10, 2 hits
3.90.228.20, 2 hits
HAMAPiMF_00452 PEPCK_GTP, 1 hit
InterProiView protein in InterPro
IPR018091 PEP_carboxykin_GTP_CS
IPR013035 PEP_carboxykinase_C
IPR008209 PEP_carboxykinase_GTP
IPR035077 PEP_carboxykinase_GTP_C
IPR035078 PEP_carboxykinase_GTP_N
IPR008210 PEP_carboxykinase_N
PANTHERiPTHR11561 PTHR11561, 1 hit
PfamiView protein in Pfam
PF00821 PEPCK_C, 1 hit
PF17297 PEPCK_N, 1 hit
PIRSFiPIRSF001348 PEP_carboxykinase_GTP, 1 hit
SUPFAMiSSF68923 SSF68923, 1 hit
PROSITEiView protein in PROSITE
PS00505 PEPCK_GTP, 1 hit

Sequencei

Sequence statusi: Complete.

A1R317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDLARLPLL EKAPTTHARL LAWVEEVAEL TQPDRIHWVD GSEAENKKLT
60 70 80 90 100
DELVEAGTLK RLNPETFPNS FAAFSDPADV ARVEEQTFIC SENERDAGFT
110 120 130 140 150
NNWMAPAEMK QKLRGLFAGS MRGRTMYVIP FVMGHLDAED PKFGVEITDS
160 170 180 190 200
AYVVASMRIM ARIGTDVLDR ITQTDAFFVP ALHSLGAPLE AGQADVAWPC
210 220 230 240 250
NTDKWIVHFP EERSIWSFGS GYGGNALLGK KCYALRIASV MARDEGWLAE
260 270 280 290 300
HMLILKLTSP EQKTYYISAA FPSACGKTNL ALLDPTIKGW KVETLGDDIT
310 320 330 340 350
WMRFGKEGEL RAVNPEAGLF GVAPGTGWGT NPNAMRAIAK GNSIFTNVAL
360 370 380 390 400
TDDGGVWWEG MTEETPAHLT DWRGESWTPD SDAPAAHPNS RFCTPIDQID
410 420 430 440 450
MLAEEYFSPE GVELSAILFG GRRKTTIPLV TEARNWSNGI FMGSTLSSET
460 470 480 490 500
TAAAAGAVGV VRRDPMAMLP FIGYDAGDYL NHWVNLSAKA NPERLPKIFL
510 520 530 540 550
VNWFRRTAEG GFAWPGFGDN ARVLKWAIER LEGKADAVET PIGFVPTGES
560 570 580 590 600
IDLEGLDMTP AEVESAVRVD PAEWATELAS IEEWFANFGE SLPAALQSEL

DGLKTRLG
Length:608
Mass (Da):66,672
Last modified:February 6, 2007 - v1
Checksum:i8CD348EF6CF1A564
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000474 Genomic DNA Translation: ABM06961.1
RefSeqiWP_011773577.1, NC_008711.1

Genome annotation databases

EnsemblBacteriaiABM06961; ABM06961; AAur_0832
GeneIDi29623856
KEGGiaau:AAur_0832

Similar proteinsi

Entry informationi

Entry nameiPCKG_PAEAT
AccessioniPrimary (citable) accession number: A1R317
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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