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A1R317

- PCKG_ARTAT

UniProt

A1R317 - PCKG_ARTAT

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Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, AAur_0832
Organism
Arthrobacter aurescens (strain TC1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821Substrate By similarity
Binding sitei224 – 2241Substrate; via amide nitrogen By similarity
Metal bindingi231 – 2311Manganese By similarity
Binding sitei231 – 2311Substrate By similarity
Metal bindingi251 – 2511Manganese; via tele nitrogen By similarity
Binding sitei273 – 2731Substrate By similarity
Active sitei275 – 2751 By similarity
Metal bindingi298 – 2981Manganese By similarity
Binding sitei391 – 3911GTP By similarity
Binding sitei422 – 4221GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi274 – 2796GTP By similarity
Nucleotide bindingi517 – 5204GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAUR290340:GI59-832-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:AAur_0832
OrganismiArthrobacter aurescens (strain TC1)
Taxonomic identifieri290340 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000637: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 608608Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation
PRO_1000072369Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi290340.AAur_0832.

Structurei

3D structure databases

ProteinModelPortaliA1R317.
SMRiA1R317. Positions 13-608.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni389 – 3913Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1R317-1 [UniParc]FASTAAdd to Basket

« Hide

MGDLARLPLL EKAPTTHARL LAWVEEVAEL TQPDRIHWVD GSEAENKKLT    50
DELVEAGTLK RLNPETFPNS FAAFSDPADV ARVEEQTFIC SENERDAGFT 100
NNWMAPAEMK QKLRGLFAGS MRGRTMYVIP FVMGHLDAED PKFGVEITDS 150
AYVVASMRIM ARIGTDVLDR ITQTDAFFVP ALHSLGAPLE AGQADVAWPC 200
NTDKWIVHFP EERSIWSFGS GYGGNALLGK KCYALRIASV MARDEGWLAE 250
HMLILKLTSP EQKTYYISAA FPSACGKTNL ALLDPTIKGW KVETLGDDIT 300
WMRFGKEGEL RAVNPEAGLF GVAPGTGWGT NPNAMRAIAK GNSIFTNVAL 350
TDDGGVWWEG MTEETPAHLT DWRGESWTPD SDAPAAHPNS RFCTPIDQID 400
MLAEEYFSPE GVELSAILFG GRRKTTIPLV TEARNWSNGI FMGSTLSSET 450
TAAAAGAVGV VRRDPMAMLP FIGYDAGDYL NHWVNLSAKA NPERLPKIFL 500
VNWFRRTAEG GFAWPGFGDN ARVLKWAIER LEGKADAVET PIGFVPTGES 550
IDLEGLDMTP AEVESAVRVD PAEWATELAS IEEWFANFGE SLPAALQSEL 600
DGLKTRLG 608
Length:608
Mass (Da):66,672
Last modified:February 6, 2007 - v1
Checksum:i8CD348EF6CF1A564
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000474 Genomic DNA. Translation: ABM06961.1.
RefSeqiYP_946629.1. NC_008711.1.

Genome annotation databases

EnsemblBacteriaiABM06961; ABM06961; AAur_0832.
GeneIDi4641427.
KEGGiaau:AAur_0832.
PATRICi20976990. VBIArtAur67810_0845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000474 Genomic DNA. Translation: ABM06961.1 .
RefSeqi YP_946629.1. NC_008711.1.

3D structure databases

ProteinModelPortali A1R317.
SMRi A1R317. Positions 13-608.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290340.AAur_0832.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM06961 ; ABM06961 ; AAur_0832 .
GeneIDi 4641427.
KEGGi aau:AAur_0832.
PATRICi 20976990. VBIArtAur67810_0845.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci AAUR290340:GI59-832-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TC1.

Entry informationi

Entry nameiPCKG_ARTAT
AccessioniPrimary (citable) accession number: A1R317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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