ID   MDH_ARTAT               Reviewed;         328 AA.
AC   A1R2B5;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Malate dehydrogenase;
DE            EC=1.1.1.37;
GN   Name=mdh; OrderedLocusNames=AAur_0570;
OS   Arthrobacter aurescens (strain TC1).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micrococcineae; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=290340;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17194220; DOI=10.1371/journal.pgen.0020214;
RA   Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B.,
RA   Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V.,
RA   Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.;
RT   "Secrets of soil survival revealed by the genome sequence of
RT   Arthrobacter aurescens TC1.";
RL   PLoS Genet. 2:2094-2106(2006).
CC   -!- FUNCTION: Catalyzes the reversible oxidation of malate to
CC       oxaloacetate (By similarity).
CC   -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
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DR   EMBL; CP000474; ABM08217.1; -; Genomic_DNA.
DR   RefSeq; YP_946377.1; -.
DR   GeneID; 4638819; -.
DR   GenomeReviews; CP000474_GR; AAur_0570.
DR   KEGG; aau:AAur_0570; -.
DR   TIGR; AAur_0570; -.
DR   OMA; A1R2B5; MIIWGNH.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0006096; P:glycolysis; IEA:InterPro.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP.
DR   HAMAP; MF_01517; -; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR001236; Lactate/malate_DH.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR001252; Malate_DH_AS.
DR   InterPro; IPR010945; Malate_DH_SF1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.90.110.10; lact_mal_DH; 1.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR23382; MDH_SF1; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   ProDom; PD003052; Mal_dehydrog; 1.
DR   TIGRFAMs; TIGR01759; MalateDH-SF1; 1.
DR   PROSITE; PS00068; MDH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN         1    328       Malate dehydrogenase.
FT                                /FTId=PRO_0000292368.
FT   NP_BIND      11     17       NAD (By similarity).
FT   NP_BIND     129    131       NAD (By similarity).
FT   ACT_SITE    187    187       Proton acceptor (By similarity).
FT   BINDING      92     92       Substrate (By similarity).
FT   BINDING      98     98       Substrate (By similarity).
FT   BINDING     105    105       NAD (By similarity).
FT   BINDING     112    112       NAD (By similarity).
FT   BINDING     131    131       Substrate (By similarity).
FT   BINDING     162    162       Substrate (By similarity).
SQ   SEQUENCE   328 AA;  34378 MW;  52DA63DC35988ED1 CRC64;
     MSSPIKIAVT GAAGQIGYSL LFRIASGALF GGDTPVQLRL LEITPALKAL EGVVMELDDC
     AFPALDSVEI GDDADHIFDG VTLALLVGAR PRSKGMERGD LLSANGAIFT AQGKALNRVA
     ADDVRIGVTG NPANTNALIA MSNAPDIPAS RFSALTRLDH NRAIGQLAAK THARVGDIRK
     MTVWGNHSAT QYPDIFHAEV AGRNAAEVVN DQDWIENEFI PTVAGRGAAI IEARGASSAA
     SAASATIDAA RDWLLGTPEG DWVSMAVASD GSYGVPEGLM YSYPVTTSGG NWEIVEGLEV
     NDFSRRKMDA TAAELFDERA AVANLGLI
//