A1R228 (FOLD1_ARTAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 38.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Bifunctional protein FolD 1 | ||||
| Gene names |
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| Organism | Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 290340 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter |
Protein attributes
| Sequence length | 294 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate By similarity. HAMAP MF_01576 |
| Catalytic activity | 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. HAMAP MF_01576 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. HAMAP MF_01576 |
| Pathway | One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01576 |
| Subunit structure | Homodimer By similarity. HAMAP MF_01576 |
| Sequence similarities | Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 294 | 294 | Bifunctional protein FolD 1 HAMAP MF_01576 | PRO_0000305790 | |||
Sequences
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References
| [1] | "Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TC1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000474 Genomic DNA. Translation: ABM06814.1. |
| RefSeq | YP_946290.1. NC_008711.1. |
3D structure databases | |
| ProteinModelPortal | A1R228. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A1R228. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 4639525. |
| GenomeReviews | Gene locus AAur_0482 in contig CP000474_GR. |
| KEGG | aau:AAur_0482. |
| PATRIC | 20976264. VBIArtAur67810_0485. |
| TIGR | AAur_0482. |
Phylogenomic databases | |
| eggNOG | COG0190. |
| HOGENOM | HBG328751. |
| OMA | CTAEAVV. |
| ProtClustDB | CLSK2784041. |
Enzyme and pathway databases | |
| BioCyc | AAUR290340:AAUR_0482-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01576. THF_DHG_CYH. [Tree] |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR000672. THF_DH/CycHdrlase. IPR020630. THF_DH/CycHdrlase_cat_dom. IPR020631. THF_DH/CycHdrlase_NAD-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K01491. |
| Pfam | PF00763. THF_DHG_CYH. 1 hit. PF02882. THF_DHG_CYH_C. 1 hit. [Graphical view] |
| PRINTS | PR00085. THFDHDRGNASE. |
| PROSITE | PS00766. THF_DHG_CYH_1. False negative. PS00767. THF_DHG_CYH_2. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FOLD1_ARTAT | ||||||||
| Accession | Primary (citable) accession number: A1R228 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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