A1R0S8 (A1R0S8_ARTAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL ABM07057.1
Ordered Locus Names:	AAur_0007

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP] EMBL ABM07057.1

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	889 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1R0S8 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 53C71B889C26F522	FASTA	889	98,699
	10 20 30 40 50 60 MSDETPEVPE PNDVEDVVLE GDVLTDRVEQ VDLQTEMQRS YLDYAMAVIV GRALPDVRDG 70 80 90 100 110 120 LKPVHRRVLY AMFDGGYRPD RSFNKCARVV GDVMGTYHPH GDMAIYDALV RLIQDWTMRY 130 140 150 160 170 180 PLALGQGNFG SPGNDGAAAP RYTETKMAQL AMEMVRDIDE ETVDFQDNYD GKNQEPTILP 190 200 210 220 230 240 ARFPNLLVNG SSGIAVGMAT NIPPHNLREV AEGVQWALDN PTATREELLE ALLLRIKGPD 250 260 270 280 290 300 FPTGATILGH KGIEDAYRTG RGSITMRAVV NVEELQGRTC LVVTELPYQA NPDNLAIKIA 310 320 330 340 350 360 ELVKDGKIQG IADLRDETSG RTGQRLVIVL KRDAVAKVVL NNLYKHTQLQ DNFSANMLAI 370 380 390 400 410 420 VDGVPRTLSL DAFIRHWVAH QMDVIARRTR YRLRKAEEEA HILRALLKAL DMLDEVIALI 430 440 450 460 470 480 RASNTTEAAR EGLMELLEID ELQARAILDM QLRRLAALER QKIQDRHSEL EAMIQEYNAI 490 500 510 520 530 540 LASEERQRQI ISEELAEIVA KHGDDRRTHI LMGFDGDMSM EDLIPEEEMV VTITRGGYVK 550 560 570 580 590 600 RTRSDNYRSQ QRGGKGIKGA QLRGDDVVEH FFVTTTHHWL LFFTNLGRVY RAKAYELAEA 610 620 630 640 650 660 GRDAKGQHVA NLLAFQPDEH IAQVLDLRDY QQAPYLVLAT KNGLVKKTRL EDYDTNRTAG 670 680 690 700 710 720 VIAINLRDED ELVSAQLVSE TDDLLLVSRK GQSIRFTATD DALRPMGRAT SGVTGMKFRE 730 740 750 760 770 780 DDELLAADVV QDGSFVFIVT EGGYAKRTAV DEYRLQGRGG LGIKVAKLAE DRGDLVGALI 790 800 810 820 830 840 VQEEDEVLVV MEGGKVVRSA VTGVPAKGRD TMGVIFAKPD KNDRIIEVAR NSERGLEVEE 850 860 870 880 SEDGLDDDVT LAANDGASEA TVTAETENDA DPEFETGAEL NEDNTGGNE

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000474 Genomic DNA. Translation: ABM07057.1.
RefSeq	YP_945840.1. NC_008711.1.
3D structure databases
ProteinModelPortal	A1R0S8.
ModBase	Search...
Protein-protein interaction databases
STRING	A1R0S8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4640623.
GenomeReviews	Gene locus AAur_0007 in contig CP000474_GR.
KEGG	aau:AAur_0007.
PATRIC	20975280. VBIArtAur67810_0007.
TIGR	AAur_0007.
Phylogenomic databases
eggNOG	COG0188.
HOGENOM	HBG635183.
OMA	TGRGRIY.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1R0S8_ARTAT

Accession

Primary (citable) accession number: A1R0S8

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)