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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Borrelia turicatae (strain 91E135)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processPyridine nucleotide biosynthesis
LigandATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTUR314724:G1G4D-795-MONOMER
UniPathwayiUPA00253; UER00332

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotation
Ordered Locus Names:BT0782
OrganismiBorrelia turicatae (strain 91E135)
Taxonomic identifieri314724 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorrelia
Proteomesi
  • UP000001205 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001253401 – 190Probable nicotinate-nucleotide adenylyltransferaseAdd BLAST190

Interactioni

Protein-protein interaction databases

STRINGi314724.BT0782

Structurei

3D structure databases

SMRiA1R0K5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107X4V Bacteria
COG1057 LUCA
HOGENOMiHOG000262780
KOiK00969
OMAiIHIGHLI
OrthoDBiPOG091H028Y

Family and domain databases

CDDicd02165 NMNAT, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00244 NaMN_adenylyltr, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR005248 NadD/NMNAT
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00482 TIGR00482, 1 hit

Sequencei

Sequence statusi: Complete.

A1R0K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIAILGGTY NPVHVGHMFL AKEIEHFLNV DKILFIPTHK PVHKCVENIS
60 70 80 90 100
VKDRIAMLKL AVQHENNMFI DECDIINGGI TYTVDTIACI RNKYVHDDIY
110 120 130 140 150
LVIGDDLFES FDSWKNPEKI IDSVNLVVVH RIYSERLVSR FKHTYIDNRI
160 170 180 190
FSISSSEIRS RIEQGLPVDY LLPFDVLQYI KSNNLYVKGK
Length:190
Mass (Da):22,038
Last modified:April 14, 2009 - v1
Checksum:i11EA2A45D3C77B69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000049 Genomic DNA Translation: AAX18096.1
RefSeqiWP_011772714.1, NC_008710.1

Genome annotation databases

EnsemblBacteriaiAAX18096; AAX18096; BT0782
KEGGibtu:BT0782

Similar proteinsi

Entry informationi

Entry nameiNADD_BORT9
AccessioniPrimary (citable) accession number: A1R0K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 14, 2009
Last modified: April 25, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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