A1QZG6 (A1QZG6_BORT9) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Autoinducer-2 production protein LuxS EMBL AAX17708.1
EC=3.13.1.- EMBL AAX17708.1

Gene names

Ordered Locus Names:

BT0377

Organism

Borrelia turicatae (strain 91E135) [Complete proteome] [HAMAP]

Taxonomic identifier

314724 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. SAAS SAAS003815
Catalytic activity	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. SAAS SAAS003815
Cofactor	Binds 1 iron ion per subunit By similarity. SAAS SAAS003815
Subunit structure	Homodimer By similarity. SAAS SAAS003815

Ontologies

Keywords
Biological process	Autoinducer synthesis SAAS SAAS003815 Quorum sensing SAAS SAAS003815
Ligand	Iron SAAS SAAS003815 Metal-binding SAAS SAAS003815
Molecular function	Hydrolase EMBL AAX17708.1 Lyase SAAS SAAS003815
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	quorum sensing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW iron ion binding Inferred from electronic annotation. Source: InterPro lyase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1QZG6 [UniParc]. Last modified April 14, 2009. Version 1. Checksum: 00A1AB4DBA1D52ED	FASTA	173	20,026
	10 20 30 40 50 60 MGKTRFRRHN KKGVQNMNKI PSFTIDHTKL KPGIYVSRKD IFDNLTFTTV DIRMKAPNRE 70 80 90 100 110 120 PVINNAEMHT IEHIGATLLR NNKVWGDKVL YFGPMGCRTG FYLILLGNYE SKDLIDLISW 130 140 150 160 170 LFHEIANFQG NIIGATEKEC GNYQDHNLNM AKYESNRYLA ILANIKEENL TYP

References

[1]

"The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever." Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000049 Genomic DNA. Translation: AAX17708.1.
RefSeq	YP_945378.1. NC_008710.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1QZG6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000000581; EBBORP00000000581; EBBORG00000000581.
GeneID	4642298.
GenomeReviews	Gene locus BT0377 in contig CP000049_GR.
KEGG	btu:BT0377.
PATRIC	20572435. VBIBorTur92789_0366.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000007432.
OMA	TTFDIRM.
ProtClustDB	PRK02260.
Family and domain databases
InterPro	IPR011249. Metalloenz_metal-bd. IPR003815. S-ribosylhomocysteinase. [Graphical view]
Gene3D	G3DSA:3.30.1360.80. S-ribosylhomocysteinase. 1 hit.
KO	K07173.
Pfam	PF02664. LuxS. 1 hit. [Graphical view]
PIRSF	PIRSF006160. AI2. 1 hit.
PRINTS	PR01487. LUXSPROTEIN.
ProDom	PD013172. S-ribosylhomocysteinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF63411. Metalloenz_metal-bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1QZG6_BORT9

Accession

Primary (citable) accession number: A1QZG6

Entry history

Integrated into UniProtKB/TrEMBL:	April 14, 2009
Last sequence update:	April 14, 2009
Last modified:	December 14, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)