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A1QZ46

- SYL_BORT9

UniProt

A1QZ46 - SYL_BORT9

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Borrelia turicatae (strain 91E135)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (14 Apr 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei622 – 6221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBTUR314724:GJ88-248-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BT0251
    OrganismiBorrelia turicatae (strain 91E135)
    Taxonomic identifieri314724 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorrelia
    ProteomesiUP000001205: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 842842Leucine--tRNA ligasePRO_1000199182Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi314724.BT0251.

    Structurei

    3D structure databases

    ProteinModelPortaliA1QZ46.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi44 – 5512"HIGH" regionAdd
    BLAST
    Motifi619 – 6235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1QZ46-1 [UniParc]FASTAAdd to Basket

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    MSEYNFTKIE KKWQNYWDKH KTYKVNEDPN IPKEKRIYIL DMFPYPSANG    50
    LHVGHPEGYT ATDILTRYKL LNGFNVLHPM GFDSFGLPAE NYAIQTGEHP 100
    KKITEKNIEK FKEQIKALGF AYDWDREIRT HDENYYKWTQ WIFLKLYKKG 150
    LAYIKEMPVW YCPDLGTVLS NEEVIQTPDG PRSERGFHKV QRKPLRQWVL 200
    KITEYAERLI KDLEEIDWPE SVKEMQKNWI GKSIGAEIEF SIKASKEKIK 250
    VFTTRPDTIF GVTYLVLAPE HNIVDKITKD ELKTIIAEYK DKEILKSDLE 300
    RTSLEKDKTG VFTGAYAINP ITEEEIPIWI GSYVLGIYGT GAVMSVPAHD 350
    ERDFEFAKKY NLPIKQVVSQ TGNNEILTKP FTENGISINT PEEFNNLKTE 400
    KVKTKVIEWL TKNKKGQKKV NYKLRDWIFS RQRYWGEPIP IIIDDDLNEI 450
    PLEEDELPLR LPEIENYKPS DTGESPLSKV QNWVNVKRNG KIYKRETNTM 500
    PQWAGSCWYY IRYLDPNNEK EFASKEKINY WMPVDLYIGG AEHSVLHLLY 550
    ARFWHKVLYD LGYVNTKEPF KKLINQGMIT SFAYQDENGI LIPNDEVKKR 600
    DNKFFSKTNN KELKQIIAKM SKSLKNIINP DDIIKEYGAD SMRIYEMFMG 650
    PLTDSKPWNT QGLIGIFRFL NKIWAIKNKE LTKESAAKEI ISGLHKTIKK 700
    VTEDIENLNF NTAISSLMIF INELLKHDKN YLEIFKPLTI ILAPFAPHLG 750
    EELWEYMGEQ PSIFKNAKWP KYDPNLIIDN TREIVLQVNG KIKDKIILNK 800
    GINEDTLKDI ALKNHKIMQN IQNKQIIKII TVKDKLINIV TK 842
    Length:842
    Mass (Da):98,516
    Last modified:April 14, 2009 - v1
    Checksum:i9F82A1025E31B5A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000049 Genomic DNA. Translation: AAX17588.1.
    RefSeqiWP_011772207.1. NC_008710.1.
    YP_945258.1. NC_008710.1.

    Genome annotation databases

    EnsemblBacteriaiAAX17588; AAX17588; BT0251.
    GeneIDi4642688.
    KEGGibtu:BT0251.
    PATRICi20572193. VBIBorTur92789_0245.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000049 Genomic DNA. Translation: AAX17588.1 .
    RefSeqi WP_011772207.1. NC_008710.1.
    YP_945258.1. NC_008710.1.

    3D structure databases

    ProteinModelPortali A1QZ46.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 314724.BT0251.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX17588 ; AAX17588 ; BT0251 .
    GeneIDi 4642688.
    KEGGi btu:BT0251.
    PATRICi 20572193. VBIBorTur92789_0245.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BTUR314724:GJ88-248-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever."
      Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91E135.

    Entry informationi

    Entry nameiSYL_BORT9
    AccessioniPrimary (citable) accession number: A1QZ46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3