Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A1QZ46 (SYL_BORT9) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:BT0251
OrganismBorrelia turicatae (strain 91E135) [Complete proteome] [HAMAP]
Taxonomic identifier314724 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorrelia

Protein attributes

Sequence length842 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 842842Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000199182

Regions

Motif44 – 5512"HIGH" region HAMAP-Rule MF_00049
Motif619 – 6235"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6221ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1QZ46 [UniParc].

Last modified April 14, 2009. Version 1.
Checksum: 9F82A1025E31B5A3

FASTA84298,516
        10         20         30         40         50         60 
MSEYNFTKIE KKWQNYWDKH KTYKVNEDPN IPKEKRIYIL DMFPYPSANG LHVGHPEGYT 

        70         80         90        100        110        120 
ATDILTRYKL LNGFNVLHPM GFDSFGLPAE NYAIQTGEHP KKITEKNIEK FKEQIKALGF 

       130        140        150        160        170        180 
AYDWDREIRT HDENYYKWTQ WIFLKLYKKG LAYIKEMPVW YCPDLGTVLS NEEVIQTPDG 

       190        200        210        220        230        240 
PRSERGFHKV QRKPLRQWVL KITEYAERLI KDLEEIDWPE SVKEMQKNWI GKSIGAEIEF 

       250        260        270        280        290        300 
SIKASKEKIK VFTTRPDTIF GVTYLVLAPE HNIVDKITKD ELKTIIAEYK DKEILKSDLE 

       310        320        330        340        350        360 
RTSLEKDKTG VFTGAYAINP ITEEEIPIWI GSYVLGIYGT GAVMSVPAHD ERDFEFAKKY 

       370        380        390        400        410        420 
NLPIKQVVSQ TGNNEILTKP FTENGISINT PEEFNNLKTE KVKTKVIEWL TKNKKGQKKV 

       430        440        450        460        470        480 
NYKLRDWIFS RQRYWGEPIP IIIDDDLNEI PLEEDELPLR LPEIENYKPS DTGESPLSKV 

       490        500        510        520        530        540 
QNWVNVKRNG KIYKRETNTM PQWAGSCWYY IRYLDPNNEK EFASKEKINY WMPVDLYIGG 

       550        560        570        580        590        600 
AEHSVLHLLY ARFWHKVLYD LGYVNTKEPF KKLINQGMIT SFAYQDENGI LIPNDEVKKR 

       610        620        630        640        650        660 
DNKFFSKTNN KELKQIIAKM SKSLKNIINP DDIIKEYGAD SMRIYEMFMG PLTDSKPWNT 

       670        680        690        700        710        720 
QGLIGIFRFL NKIWAIKNKE LTKESAAKEI ISGLHKTIKK VTEDIENLNF NTAISSLMIF 

       730        740        750        760        770        780 
INELLKHDKN YLEIFKPLTI ILAPFAPHLG EELWEYMGEQ PSIFKNAKWP KYDPNLIIDN 

       790        800        810        820        830        840 
TREIVLQVNG KIKDKIILNK GINEDTLKDI ALKNHKIMQN IQNKQIIKII TVKDKLINIV 


TK 

« Hide

References

[1]"The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever."
Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91E135.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000049 Genomic DNA. Translation: AAX17588.1.
RefSeqYP_945258.1. NC_008710.1.

3D structure databases

ProteinModelPortalA1QZ46.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING314724.BT0251.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX17588; AAX17588; BT0251.
GeneID4642688.
KEGGbtu:BT0251.
PATRIC20572193. VBIBorTur92789_0245.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycBTUR314724:GJ88-248-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_BORT9
AccessionPrimary (citable) accession number: A1QZ46
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 14, 2009
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries