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A1QZ46

- SYL_BORT9

UniProt

A1QZ46 - SYL_BORT9

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Borrelia turicatae (strain 91E135)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTUR314724:GJ88-248-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BT0251
OrganismiBorrelia turicatae (strain 91E135)
Taxonomic identifieri314724 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorrelia
ProteomesiUP000001205: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 842842Leucine--tRNA ligasePRO_1000199182Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314724.BT0251.

Structurei

3D structure databases

ProteinModelPortaliA1QZ46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5512"HIGH" regionAdd
BLAST
Motifi619 – 6235"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1QZ46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEYNFTKIE KKWQNYWDKH KTYKVNEDPN IPKEKRIYIL DMFPYPSANG
60 70 80 90 100
LHVGHPEGYT ATDILTRYKL LNGFNVLHPM GFDSFGLPAE NYAIQTGEHP
110 120 130 140 150
KKITEKNIEK FKEQIKALGF AYDWDREIRT HDENYYKWTQ WIFLKLYKKG
160 170 180 190 200
LAYIKEMPVW YCPDLGTVLS NEEVIQTPDG PRSERGFHKV QRKPLRQWVL
210 220 230 240 250
KITEYAERLI KDLEEIDWPE SVKEMQKNWI GKSIGAEIEF SIKASKEKIK
260 270 280 290 300
VFTTRPDTIF GVTYLVLAPE HNIVDKITKD ELKTIIAEYK DKEILKSDLE
310 320 330 340 350
RTSLEKDKTG VFTGAYAINP ITEEEIPIWI GSYVLGIYGT GAVMSVPAHD
360 370 380 390 400
ERDFEFAKKY NLPIKQVVSQ TGNNEILTKP FTENGISINT PEEFNNLKTE
410 420 430 440 450
KVKTKVIEWL TKNKKGQKKV NYKLRDWIFS RQRYWGEPIP IIIDDDLNEI
460 470 480 490 500
PLEEDELPLR LPEIENYKPS DTGESPLSKV QNWVNVKRNG KIYKRETNTM
510 520 530 540 550
PQWAGSCWYY IRYLDPNNEK EFASKEKINY WMPVDLYIGG AEHSVLHLLY
560 570 580 590 600
ARFWHKVLYD LGYVNTKEPF KKLINQGMIT SFAYQDENGI LIPNDEVKKR
610 620 630 640 650
DNKFFSKTNN KELKQIIAKM SKSLKNIINP DDIIKEYGAD SMRIYEMFMG
660 670 680 690 700
PLTDSKPWNT QGLIGIFRFL NKIWAIKNKE LTKESAAKEI ISGLHKTIKK
710 720 730 740 750
VTEDIENLNF NTAISSLMIF INELLKHDKN YLEIFKPLTI ILAPFAPHLG
760 770 780 790 800
EELWEYMGEQ PSIFKNAKWP KYDPNLIIDN TREIVLQVNG KIKDKIILNK
810 820 830 840
GINEDTLKDI ALKNHKIMQN IQNKQIIKII TVKDKLINIV TK
Length:842
Mass (Da):98,516
Last modified:April 14, 2009 - v1
Checksum:i9F82A1025E31B5A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000049 Genomic DNA. Translation: AAX17588.1.
RefSeqiWP_011772207.1. NC_008710.1.
YP_945258.1. NC_008710.1.

Genome annotation databases

EnsemblBacteriaiAAX17588; AAX17588; BT0251.
GeneIDi4642688.
KEGGibtu:BT0251.
PATRICi20572193. VBIBorTur92789_0245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000049 Genomic DNA. Translation: AAX17588.1 .
RefSeqi WP_011772207.1. NC_008710.1.
YP_945258.1. NC_008710.1.

3D structure databases

ProteinModelPortali A1QZ46.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 314724.BT0251.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX17588 ; AAX17588 ; BT0251 .
GeneIDi 4642688.
KEGGi btu:BT0251.
PATRICi 20572193. VBIBorTur92789_0245.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BTUR314724:GJ88-248-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever."
    Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91E135.

Entry informationi

Entry nameiSYL_BORT9
AccessioniPrimary (citable) accession number: A1QZ46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 14, 2009
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3