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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Borrelia turicatae (strain 91E135)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei622ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTUR314724:G1G4D-248-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BT0251
OrganismiBorrelia turicatae (strain 91E135)
Taxonomic identifieri314724 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorrelia
Proteomesi
  • UP000001205 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001991821 – 842Leucine--tRNA ligaseAdd BLAST842

Interactioni

Protein-protein interaction databases

STRINGi314724.BT0251

Structurei

3D structure databases

ProteinModelPortaliA1QZ46
SMRiA1QZ46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi44 – 55"HIGH" regionAdd BLAST12
Motifi619 – 623"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A1QZ46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEYNFTKIE KKWQNYWDKH KTYKVNEDPN IPKEKRIYIL DMFPYPSANG
60 70 80 90 100
LHVGHPEGYT ATDILTRYKL LNGFNVLHPM GFDSFGLPAE NYAIQTGEHP
110 120 130 140 150
KKITEKNIEK FKEQIKALGF AYDWDREIRT HDENYYKWTQ WIFLKLYKKG
160 170 180 190 200
LAYIKEMPVW YCPDLGTVLS NEEVIQTPDG PRSERGFHKV QRKPLRQWVL
210 220 230 240 250
KITEYAERLI KDLEEIDWPE SVKEMQKNWI GKSIGAEIEF SIKASKEKIK
260 270 280 290 300
VFTTRPDTIF GVTYLVLAPE HNIVDKITKD ELKTIIAEYK DKEILKSDLE
310 320 330 340 350
RTSLEKDKTG VFTGAYAINP ITEEEIPIWI GSYVLGIYGT GAVMSVPAHD
360 370 380 390 400
ERDFEFAKKY NLPIKQVVSQ TGNNEILTKP FTENGISINT PEEFNNLKTE
410 420 430 440 450
KVKTKVIEWL TKNKKGQKKV NYKLRDWIFS RQRYWGEPIP IIIDDDLNEI
460 470 480 490 500
PLEEDELPLR LPEIENYKPS DTGESPLSKV QNWVNVKRNG KIYKRETNTM
510 520 530 540 550
PQWAGSCWYY IRYLDPNNEK EFASKEKINY WMPVDLYIGG AEHSVLHLLY
560 570 580 590 600
ARFWHKVLYD LGYVNTKEPF KKLINQGMIT SFAYQDENGI LIPNDEVKKR
610 620 630 640 650
DNKFFSKTNN KELKQIIAKM SKSLKNIINP DDIIKEYGAD SMRIYEMFMG
660 670 680 690 700
PLTDSKPWNT QGLIGIFRFL NKIWAIKNKE LTKESAAKEI ISGLHKTIKK
710 720 730 740 750
VTEDIENLNF NTAISSLMIF INELLKHDKN YLEIFKPLTI ILAPFAPHLG
760 770 780 790 800
EELWEYMGEQ PSIFKNAKWP KYDPNLIIDN TREIVLQVNG KIKDKIILNK
810 820 830 840
GINEDTLKDI ALKNHKIMQN IQNKQIIKII TVKDKLINIV TK
Length:842
Mass (Da):98,516
Last modified:April 14, 2009 - v1
Checksum:i9F82A1025E31B5A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000049 Genomic DNA Translation: AAX17588.1
RefSeqiWP_011772207.1, NC_008710.1

Genome annotation databases

EnsemblBacteriaiAAX17588; AAX17588; BT0251
KEGGibtu:BT0251

Similar proteinsi

Entry informationi

Entry nameiSYL_BORT9
AccessioniPrimary (citable) accession number: A1QZ46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 14, 2009
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health