Unreviewed, UniProtKB/TrEMBL A1QVU0 (A1QVU0_MYCTF)

Names and origin

Protein names

Recommended name:
    DNA ligase RuleBase RU000618V6
    EC=6.5.1.2

Gene names

Ordered Locus Names:	TBFG_02991
ORF Names:	TBFG_13029 EMBL ABR07356.1

Organism

Mycobacterium tuberculosis (strain F11)

Taxonomic identifier

336982 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	691 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA By similarity. Spearmint SPM004149
Catalytic activity	NAD+ + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + nicotinamide nucleotide + (deoxyribonucleotide)(n+m). RuleBase RU000618V6 Spearmint SPM004149
Cofactor	Magnesium or manganese By similarity. Spearmint SPM004149
Sequence similarities	Belongs to the NAD-dependent DNA ligase family. RuleBase RU004197V0 Contains 1 BRCT domain. Spearmint SPM004149

Ontologies

Keywords
Biological process	DNA damage DNA repair RuleBase RU000618V6 Spearmint SPM004149 DNA replication RuleBase RU000618V6 Spearmint SPM004149
Ligand	Magnesium Spearmint SPM004149 Manganese Spearmint SPM004149 Metal-binding Spearmint SPM004149 NAD RuleBase RU000618V6 Spearmint SPM004149 Zinc Spearmint SPM004149
Molecular function	Ligase RuleBase RU000618V6 Spearmint SPM004149
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: InterPro DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	DNA ligase (NAD+) activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1QVU0-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 94AD5AEDCD065567	FASTA	691	75,289
	10 20 30 40 50 60 MSSPDADQTA PEVLRQWQAL AEEVREHQFR YYVRDAPIIS DAEFDELLRR LEALEEQHPE 70 80 90 100 110 120 LRTPDSPTQL VGGAGFATDF EPVDHLERML SLDNAFTADE LAAWAGRIHA EVGDAAHYLC 130 140 150 160 170 180 ELKIDGVALS LVYREGRLTR ASTRGDGRTG EDVTLNARTI ADVPERLTPG DDYPVPEVLE 190 200 210 220 230 240 VRGEVFFRLD DFQALNASLV EEGKAPFANP RNSAAGSLRQ KDPAVTARRR LRMICHGLGH 250 260 270 280 290 300 VEGFRPATLH QAYLALRAWG LPVSEHTTLA TDLAGVRERI DYWGEHRHEV DHEIDGVVVK 310 320 330 340 350 360 VDEVALQRRL GSTSRAPRWA IAYKYPPEEA QTKLLDIRVN VGRTGRITPF AFMTPVKVAG 370 380 390 400 410 420 STVGQATLHN ASEIKRKGVL IGDTVVIRKA GDVIPEVLGP VVELRDGSER EFIMPTTCPE 430 440 450 460 470 480 CGSPLAPEKE GDADIRCPNA RGCPGQLRER VFHVASRNGL DIEVLGYEAG VALLQAKVIA 490 500 510 520 530 540 DEGELFALTE RDLLRTDLFR TKAGELSANG KRLLVNLDKA KAAPLWRVLV ALSIRHVGPT 550 560 570 580 590 600 AARALATEFG SLDAIAAAST DQLAAVEGVG PTIAAAVTEW FAVDWHREIV DKWRAAGVRM 610 620 630 640 650 660 VDERDESVPR TLAGLTIVVT GSLTGFSRDD AKEAIVARGG KAAGSVSKKT NYVVAGDSPG 670 680 690 SKYDKAVELG VPILDEDGFR RLLADGPASR T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Mycobacterium tuberculosis F11 genome." Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Jaffe D., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E., Brockman W., Rounsley S., Young S., LaButti K., Pushparaj V. , DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C.D., Zeng Q., Yandava C., O'Leary S., Alvarado L., Murray M., Victor T. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The Complete Genome Sequence of Mycobacterium tuberculosis F11." The Broad Institute Genome Sequencing Platform Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: F11 EMBL ABR07356.1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000717 Genomic DNA. Translation: ABR07356.1. CM000286 Genomic DNA. Translation: EAX14852.1.
RefSeq	YP_001288958.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5223717.
Phylogenomic databases
OMA	A1QVU0. YKFPAQE.
Family and domain databases
InterPro	IPR001357. BRCT. IPR018239. DNA_ligase_AS. IPR004150. DNA_ligase_OB. IPR001679. DNAligase. IPR013839. DNAligase_adenylation. IPR013840. DNAligase_N. IPR003583. Helix-hairpin-helix_DNA-bd. IPR000445. HhH_motif. IPR012340. NA-bd_OB-fold. IPR004149. Znf_DNAligase_C4. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
Pfam	PF00533. BRCT. 1 hit. PF01653. DNA_ligase_aden. 1 hit. PF03120. DNA_ligase_OB. 1 hit. PF03119. DNA_ligase_ZBD. 1 hit. PF00633. HHH. 1 hit. [Graphical view]
PIRSF	PIRSF001604. LigA. 1 hit.
ProDom	PD003944. DNAligase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00292. BRCT. 1 hit. SM00278. HhH1. 2 hits. SM00532. LIGANc. 1 hit. [Graphical view]
TIGRFAMs	TIGR00575. dnlj. 1 hit.
PROSITE	PS50172. BRCT. 1 hit. PS01055. DNA_LIGASE_N1. 1 hit. PS01056. DNA_LIGASE_N2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1QVU0_MYCTF

Accession

Primary (citable) accession number: A1QVU0

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)