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A1QNY1

- MEND_MYCTF

UniProt

A1QNY1 - MEND_MYCTF

Protein

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene

menD

Organism
Mycobacterium tuberculosis (strain F11)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).UniRule annotation

    Catalytic activityi

    Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotation

    Cofactori

    Magnesium or manganese.UniRule annotation
    Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Menaquinone biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciMTUB336982:GH7I-569-MONOMER.
    UniPathwayiUPA00079; UER00164.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotation (EC:2.2.1.9UniRule annotation)
    Short name:
    SEPHCHC synthaseUniRule annotation
    Alternative name(s):
    Menaquinone biosynthesis protein MenDUniRule annotation
    Gene namesi
    Name:menDUniRule annotation
    Ordered Locus Names:TBFG_10565
    OrganismiMycobacterium tuberculosis (strain F11)
    Taxonomic identifieri336982 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000000660: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5545542-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthasePRO_0000341786Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi336982.TBFG_10565.

    Structurei

    3D structure databases

    ProteinModelPortaliA1QNY1.
    SMRiA1QNY1. Positions 1-547.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TPP enzyme family. MenD subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1165.
    HOGENOMiHOG000218359.
    KOiK02551.
    OMAiWRSAVCR.
    OrthoDBiEOG6NWBQW.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01659. MenD.
    InterProiIPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    [Graphical view]
    PfamiPF02776. TPP_enzyme_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004983. MenD. 1 hit.
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00173. menD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1QNY1-1 [UniParc]FASTAAdd to Basket

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    MNPSTTQARV VVDELIRGGV RDVVLCPGSR NAPLAFALQD ADRSGRIRLH    50
    VRIDERTAGY LAIGLAIGAG APVCVAMTSG TAVANLGPAV VEANYARVPL 100
    IVLSANRPYE LLGTGANQTM EQLGYFGTQV RASISLGLAE DAPERTSALN 150
    ATWRSATCRV LAAATGARTA NAGPVHFDIP LREPLVPDPE PLGAVTPPGR 200
    PAGKPWTYTP PVTFDQPLDI DLSVDTVVIS GHGAGVHPNL AALPTVAEPT 250
    APRSGDNPLH PLALPLLRPQ QVIMLGRPTL HRPVSVLLAD AEVPVFALTT 300
    GPRWPDVSGN SQATGTRAVT TGAPRPAWLD RCAAMNRHAI AAVREQLAAH 350
    PLTTGLHVAA AVSHALRPGD QLVLGASNPV RDVALAGLDT RGIRVRSNRG 400
    VAGIDGTVST AIGAALAYEG AHERTGSPDS PPRTIALIGD LTFVHDSSGL 450
    LIGPTEPIPR SLTIVVSNDN GGGIFELLEQ GDPRFSDVSS RIFGTPHDVD 500
    VGALCRAYHV ESRQIEVDEL GPTLDQPGAG MRVLEVKADR SSLRQLHAAI 550
    KAAL 554
    Length:554
    Mass (Da):57,836
    Last modified:February 6, 2007 - v1
    Checksum:i879423AAB00F36A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000717 Genomic DNA. Translation: ABR04908.1.
    RefSeqiYP_001286510.1. NC_009565.1.

    Genome annotation databases

    EnsemblBacteriaiABR04908; ABR04908; TBFG_10565.
    GeneIDi5221229.
    KEGGimtf:TBFG_10565.
    PATRICi18131884. VBIMycTub9078_0615.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000717 Genomic DNA. Translation: ABR04908.1 .
    RefSeqi YP_001286510.1. NC_009565.1.

    3D structure databases

    ProteinModelPortali A1QNY1.
    SMRi A1QNY1. Positions 1-547.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336982.TBFG_10565.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR04908 ; ABR04908 ; TBFG_10565 .
    GeneIDi 5221229.
    KEGGi mtf:TBFG_10565.
    PATRICi 18131884. VBIMycTub9078_0615.

    Phylogenomic databases

    eggNOGi COG1165.
    HOGENOMi HOG000218359.
    KOi K02551.
    OMAi WRSAVCR.
    OrthoDBi EOG6NWBQW.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00164 .
    BioCyci MTUB336982:GH7I-569-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01659. MenD.
    InterProi IPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    [Graphical view ]
    Pfami PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004983. MenD. 1 hit.
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00173. menD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: F11.

    Entry informationi

    Entry nameiMEND_MYCTF
    AccessioniPrimary (citable) accession number: A1QNY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3