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Protein

Proteasomal ubiquitin receptor ADRM1

Gene

ADRM1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasomal ubiquitin receptor ADRM1
Alternative name(s):
Rpn13 homolog
Gene namesi
Name:ADRM1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 407406Proteasomal ubiquitin receptor ADRM1PRO_0000286070Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Modified residuei15 – 151PhosphoserineBy similarity
Cross-linki34 – 34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei127 – 1271PhosphotyrosineBy similarity
Modified residuei140 – 1401PhosphoserineBy similarity
Modified residuei211 – 2111PhosphoserineBy similarity
Modified residuei217 – 2171PhosphothreonineBy similarity
Modified residuei405 – 4051PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiA1L5A6.
PeptideAtlasiA1L5A6.
PRIDEiA1L5A6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003058.
ExpressionAtlasiA1L5A6. baseline and differential.

Interactioni

Subunit structurei

Interacts with PSMD1, ubiquitin and UCHL5.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003974.

Structurei

3D structure databases

ProteinModelPortaliA1L5A6.
SMRiA1L5A6. Positions 22-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 130109PHAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 132131Interaction with PSMD1By similarityAdd
BLAST
Regioni362 – 40746Interaction with UCHL5By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 19965Gly-richAdd
BLAST
Compositional biasi203 – 25755Ser-richAdd
BLAST

Domaini

The PH domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of K48-linked diubiquitin allows UCHL5 access to the distal subunit (By similarity).By similarity

Sequence similaritiesi

Belongs to the ADRM1 family.Curated
Contains 1 PH domain.Curated

Phylogenomic databases

eggNOGiKOG3037. Eukaryota.
ENOG410XSJJ. LUCA.
GeneTreeiENSGT00390000013839.
HOGENOMiHOG000005947.
HOVERGENiHBG073518.
InParanoidiA1L5A6.
OMAiKRVDQCK.
OrthoDBiEOG091G0FEO.
TreeFamiTF313410.

Family and domain databases

InterProiIPR006773. 26S_Psome_Ubiquitin-recp_Rpn13.
IPR032368. RPN13_C.
[Graphical view]
PANTHERiPTHR12225. PTHR12225. 2 hits.
PfamiPF04683. Proteasom_Rpn13. 1 hit.
PF16550. RPN13_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1L5A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSGALFPS LVPGSRGSSN KYLVEFRAGK MSLKGTTVTP DKRKGLVYIQ
60 70 80 90 100
QTDDSLIHFC WKDRTSGNVE DDLIIFPDDC EFKRVPQCPS GRVYVLKFKA
110 120 130 140 150
GSKRLFFWMQ EPKTDQDEEH CRKVNEYLNN PPMPGALGAS GSGGHELSAL
160 170 180 190 200
GGEGGLQSLL GNMSHSQLMQ LIGPAGLGGL GGLGALTGPG LASLLGSGGP
210 220 230 240 250
PASSSSSSSR SQSAAVTPSS TTSSTRATPA PSAPAAASAT SPSPAPSSGD
260 270 280 290 300
GASTAASPAQ PIQLSDLQSI LATMSVPAGP GGGQQVDLAS VLTPEIMAPI
310 320 330 340 350
LANADVQERL LPYLPSGESL PQTAEEIQNT LTSPQFQQAL GMFSAALASG
360 370 380 390 400
QLGPLMCQFG LPAEAVEAAN KGDVEAFAKA MQNSASPEQQ EGDGKDKKDE

EEDMSLD
Length:407
Mass (Da):41,955
Last modified:February 6, 2007 - v1
Checksum:i622F17326AD66E64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT029893 mRNA. Translation: ABM21559.1.
RefSeqiNP_001073751.1. NM_001080282.1.
UniGeneiBt.9233.

Genome annotation databases

EnsembliENSBTAT00000003974; ENSBTAP00000003974; ENSBTAG00000003058.
GeneIDi519729.
KEGGibta:519729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT029893 mRNA. Translation: ABM21559.1.
RefSeqiNP_001073751.1. NM_001080282.1.
UniGeneiBt.9233.

3D structure databases

ProteinModelPortaliA1L5A6.
SMRiA1L5A6. Positions 22-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003974.

Proteomic databases

PaxDbiA1L5A6.
PeptideAtlasiA1L5A6.
PRIDEiA1L5A6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003974; ENSBTAP00000003974; ENSBTAG00000003058.
GeneIDi519729.
KEGGibta:519729.

Organism-specific databases

CTDi11047.

Phylogenomic databases

eggNOGiKOG3037. Eukaryota.
ENOG410XSJJ. LUCA.
GeneTreeiENSGT00390000013839.
HOGENOMiHOG000005947.
HOVERGENiHBG073518.
InParanoidiA1L5A6.
OMAiKRVDQCK.
OrthoDBiEOG091G0FEO.
TreeFamiTF313410.

Gene expression databases

BgeeiENSBTAG00000003058.
ExpressionAtlasiA1L5A6. baseline and differential.

Family and domain databases

InterProiIPR006773. 26S_Psome_Ubiquitin-recp_Rpn13.
IPR032368. RPN13_C.
[Graphical view]
PANTHERiPTHR12225. PTHR12225. 2 hits.
PfamiPF04683. Proteasom_Rpn13. 1 hit.
PF16550. RPN13_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADRM1_BOVIN
AccessioniPrimary (citable) accession number: A1L5A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.