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Protein

Alcohol dehydrogenase-like 3

Gene

At1g32780

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Zinc 1; catalyticBy similarity1
Metal bindingi50Zinc 1By similarity1
Binding sitei50NADBy similarity1
Binding sitei50SubstrateBy similarity1
Metal bindingi71Zinc 1; catalyticBy similarity1
Binding sitei71SubstrateBy similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi188Zinc 1; catalyticBy similarity1
Binding sitei237NADBy similarity1
Binding sitei242NADBy similarity1
Binding sitei283NAD; via carbonyl oxygenBy similarity1
Binding sitei306NAD; via carbonyl oxygenBy similarity1
Binding sitei333NAD; via amide nitrogenBy similarity1
Binding sitei383NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi213 – 218NADBy similarity6
Nucleotide bindingi306 – 308NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G32780-MONOMER.
ReactomeiR-ATH-2161541. Abacavir metabolism.
R-ATH-5365859. RA biosynthesis pathway.
R-ATH-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase-like 3 (EC:1.1.1.1By similarity)
Gene namesi
Ordered Locus Names:At1g32780
ORF Names:F6N18.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G32780.
TAIRilocus:2035619. AT1G32780.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002991851 – 394Alcohol dehydrogenase-like 3Add BLAST394

Proteomic databases

PaxDbiA1L4Y2.

Expressioni

Gene expression databases

ExpressionAtlasiA1L4Y2. baseline and differential.
GenevisibleiA1L4Y2. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT1G32780.1.

Structurei

3D structure databases

ProteinModelPortaliA1L4Y2.
SMRiA1L4Y2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.
InParanoidiA1L4Y2.
KOiK00001.
OMAiESNLCER.
OrthoDBiEOG09360E3N.
PhylomeDBiA1L4Y2.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

A1L4Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETQGKVIT CKAAVVWGPK VPLVIQEICV DPPQKMEVRV KILYSSICHT
60 70 80 90 100
DLGCWNGTNE AERAFPRILG HEAVGIVESV GEGVKDVKEG DYVIPTFNGE
110 120 130 140 150
CGECKVCKRE ESNLCERYHV DPMKRVMVND GGTRFSTTIN KDGGSSQSQP
160 170 180 190 200
IYHFLNTSTF TEYTVLDSAC VVKIDPNSPL KQMSLLSCGV STGVGAAWNI
210 220 230 240 250
ANVKEGKSTA VFGLGSVGLA VAEGARARGA SRIIGVDANA SKFEKGKLMG
260 270 280 290 300
VTDFINPKDL TKPVHQMIRE ITGGGVDYSF ECTGNVDVLR EAFLSTHVGW
310 320 330 340 350
GSTVLVGIYP TPRTLPLHPM ELFDGRRITG SVFGGFKPKS QLPNFAQQCM
360 370 380 390
KGVVKLEPFI TNELPFEKIN DAFQLLRDGK SLRCILQISK LLKR
Length:394
Mass (Da):42,908
Last modified:February 6, 2007 - v1
Checksum:i2D9B6DE696AA201C
GO

Sequence cautioni

The sequence AAF25975 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159Missing in AAM64605 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC017118 Genomic DNA. Translation: AAF25975.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE31528.1.
BT029769 mRNA. Translation: ABM06039.1.
AY087044 mRNA. Translation: AAM64605.1.
RefSeqiNP_564409.1. NM_103012.4.
UniGeneiAt.40067.

Genome annotation databases

EnsemblPlantsiAT1G32780.1; AT1G32780.1; AT1G32780.
GeneIDi840172.
GrameneiAT1G32780.1; AT1G32780.1; AT1G32780.
KEGGiath:AT1G32780.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADHL3_ARATH
AccessioniPrimary (citable) accession number: A1L4Y2
Secondary accession number(s): Q8LBR3, Q9LPI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 6, 2007
Last modified: May 10, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families