A1L4M7 (CU034_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative uncharacterized protein encoded by LINC00478

Gene names

Name:	LINC00478
Synonyms:	C21orf34, C21orf35

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	104 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Tissue specificity	Ubiquitous. Ref.2
Caution	Product of a dubious CDS prediction. May be a non-coding RNA. Previously annotated as two separate genes based on spliced ESTs, C21orf34 and C21orf35 were shown by RT-PCR experiments to represent a single gene.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: LINC00478 is composed of at least 11 exons, of which only 3 are consistently predicted by coding exon-prediction programs. Exons 3, 6, 7 and 10 are alternatively spliced, suggesting multiple transcripts can be produced. The longest possible transcript is 1300 bp, with the only significant open reading frame located in exons 1 and 2. If this indeed represents a translated product, it implies LINC00478 has an unusual 3'-UTR composed of 9 exons.

Isoform 1 (identifier: A1L4M7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 104	104	Putative uncharacterized protein encoded by LINC00478		PRO_0000311852

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 51AB6780C53DDAAA	FASTA	104	12,149
	10 20 30 40 50 60 MEIILELQQS AQLHNREAGT QIDRQISQLV EGASGWQLWA FGCWTTIGKT EMEQGQKIAH 70 80 90 100 FYSTQLLLFH DLQEFYWDNY PNKLQAFYPN GALSEMKRIL NVKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis." Gardiner K., Slavov D., Bechtel L., Davisson M. Genomics 79:833-843(2002) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE PRODUCTS, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC130602 mRNA. Translation: AAI30603.1. BC130606 mRNA. Translation: AAI30607.1.
IPI	IPI00478724.
UniGene	Hs.473394.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC21P017443.
HGNC	HGNC:1274. LINC00478.
neXtProt	NX_A1L4M7.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG130250.
InParanoid	A1L4M7.
OrthoDB	EOG4BRWN7.
Gene expression databases
CleanEx	HS_C21orf34.
Genevestigator	A1L4M7.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	LINC00478. human.

Entry information

Entry name

CU034_HUMAN

Accession

Primary (citable) accession number: A1L4M7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	February 6, 2007
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.