A1L4M7 (CU034_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified April 3, 2013. Version 41. History...
Names and origin
|Protein names||Recommended name:|
Putative uncharacterized protein encoded by LINC00478
|Organism||Homo sapiens (Human) [Reference proteome]|
|Taxonomic identifier||9606 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo|
|Sequence length||104 AA.|
General annotation (Comments)
Product of a dubious CDS prediction. May be a non-coding RNA. Previously annotated as two separate genes based on spliced ESTs, C21orf34 and C21orf35 were shown by RT-PCR experiments to represent a single gene.
|This entry describes 1 isoform produced by alternative splicing. [Select]|
Note: LINC00478 is composed of at least 11 exons, of which only 3 are consistently predicted by coding exon-prediction programs. Exons 3, 6, 7 and 10 are alternatively spliced, suggesting multiple transcripts can be produced. The longest possible transcript is 1300 bp, with the only significant open reading frame located in exons 1 and 2. If this indeed represents a translated product, it implies LINC00478 has an unusual 3'-UTR composed of 9 exons.
|Isoform 1 (identifier: A1L4M7-1) |
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 104||104||Putative uncharacterized protein encoded by LINC00478||PRO_0000311852|
|||"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."|
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
|||"Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis."|
Gardiner K., Slavov D., Bechtel L., Davisson M.
Genomics 79:833-843(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE PRODUCTS, TISSUE SPECIFICITY.
|+||Additional computationally mapped references.|
|BC130602 mRNA. Translation: AAI30603.1.|
BC130606 mRNA. Translation: AAI30607.1.
3D structure databases
Protocols and materials databases
|HGNC||HGNC:1274. LINC00478. |
Gene expression databases
Family and domain databases
|ChiTaRS||LINC00478. human. |
|Accession||Primary (citable) accession number: A1L4M7|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|
|Disclaimer||Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.|
|Human chromosome 21|
Human chromosome 21: entries, gene names and cross-references to MIM