Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A1L4M7 (CU034_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative uncharacterized protein encoded by LINC00478
Gene names
Name:LINC00478
Synonyms:C21orf34, C21orf35
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length104 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Tissue specificity

Ubiquitous. Ref.2

Caution

Product of a dubious CDS prediction. May be a non-coding RNA. Previously annotated as two separate genes based on spliced ESTs, C21orf34 and C21orf35 were shown by RT-PCR experiments to represent a single gene.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: LINC00478 is composed of at least 11 exons, of which only 3 are consistently predicted by coding exon-prediction programs. Exons 3, 6, 7 and 10 are alternatively spliced, suggesting multiple transcripts can be produced. The longest possible transcript is 1300 bp, with the only significant open reading frame located in exons 1 and 2. If this indeed represents a translated product, it implies LINC00478 has an unusual 3'-UTR composed of 9 exons.
Isoform 1 (identifier: A1L4M7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 104104Putative uncharacterized protein encoded by LINC00478
PRO_0000311852

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 51AB6780C53DDAAA

FASTA10412,149
        10         20         30         40         50         60 
MEIILELQQS AQLHNREAGT QIDRQISQLV EGASGWQLWA FGCWTTIGKT EMEQGQKIAH 

        70         80         90        100 
FYSTQLLLFH DLQEFYWDNY PNKLQAFYPN GALSEMKRIL NVKI 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis."
Gardiner K., Slavov D., Bechtel L., Davisson M.
Genomics 79:833-843(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE PRODUCTS, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC130602 mRNA. Translation: AAI30603.1.
BC130606 mRNA. Translation: AAI30607.1.
UniGeneHs.473394.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC21P017443.
HGNCHGNC:1274. LINC00478.
neXtProtNX_A1L4M7.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG130250.
InParanoidA1L4M7.

Gene expression databases

CleanExHS_C21orf34.
GenevestigatorA1L4M7.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSLINC00478. human.

Entry information

Entry nameCU034_HUMAN
AccessionPrimary (citable) accession number: A1L4M7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 6, 2007
Last modified: January 22, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM