Reviewed, UniProtKB/Swiss-Prot A1L4M7 (CU034_HUMAN)

Names and origin

Protein names

Recommended name:
    Putative uncharacterized protein C21orf34

Gene names

Name:	C21orf34
Synonyms:	C21orf35

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	104 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Ubiquitous. Ref.2
Caution	Previously annotated as two separate genes based on spliced ESTs, C21orf34 and C21orf35 were shown by RT-PCR experiments to represent a single gene.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: C21orf34 is composed of at least 11 exons, of which only 3 are consistently predicted by coding exon-prediction programs. Exons 3, 6, 7 and 10 are alternatively spliced, suggesting multiple transcripts can be produced. The longest possible transcript is 1300 bp, with the only significant open reading frame located in exons 1 and 2. If this indeed represents a translated product, it implies C21orf34 has an unusual 3'-UTR composed of 9 exons.

Isoform 1 (identifier: A1L4M7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 104	104	Putative uncharacterized protein C21orf34		PRO_0000311852

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 51AB6780C53DDAAA	FASTA	104	12,149
	10 20 30 40 50 60 MEIILELQQS AQLHNREAGT QIDRQISQLV EGASGWQLWA FGCWTTIGKT EMEQGQKIAH 70 80 90 100 FYSTQLLLFH DLQEFYWDNY PNKLQAFYPN GALSEMKRIL NVKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis." Gardiner K., Slavov D., Bechtel L., Davisson M. Genomics 79:833-843(2002) [PubMed: 12036298] [Abstract] Cited for: ALTERNATIVE PRODUCTS, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC130602 mRNA. Translation: AAI30603.1. BC130606 mRNA. Translation: AAI30607.1.
IPI	IPI00478724.
UniGene	Hs.473394
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENST00000439037; ENSP00000391948; ENSG00000174496; Homo sapiens. [Genome view]
UCSC	uc002ykc.1. human.
Organism-specific databases
GeneCards	GC21P016364.
HGNC	HGNC:1274. C21orf34.
PharmGKB	PA25829.
GenAtlas	Search...
Phylogenomic databases
OMA	WQLWAIG
Gene expression databases
CleanEx	HS_C21orf34.
Genevestigator	A1L4M7.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	102381.

Entry information

Entry name

CU034_HUMAN

Accession

Primary (citable) accession number: A1L4M7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	February 6, 2007
Last modified:	November 24, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.