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A1L4M7

- CU034_HUMAN

UniProt

A1L4M7 - CU034_HUMAN

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Protein
Putative uncharacterized protein encoded by LINC00478
Gene
LINC00478, C21orf34, C21orf35
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uncharacterized protein encoded by LINC00478
Gene namesi
Synonyms:C21orf34, C21orf35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:1274. LINC00478.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 104104Putative uncharacterized protein encoded by LINC00478
PRO_0000311852Add
BLAST

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

CleanExiHS_C21orf34.
GenevestigatoriA1L4M7.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG130250.
InParanoidiA1L4M7.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: LINC00478 is composed of at least 11 exons, of which only 3 are consistently predicted by coding exon-prediction programs. Exons 3, 6, 7 and 10 are alternatively spliced, suggesting multiple transcripts can be produced. The longest possible transcript is 1300 bp, with the only significant open reading frame located in exons 1 and 2. If this indeed represents a translated product, it implies LINC00478 has an unusual 3'-UTR composed of 9 exons.

Isoform 1 (identifier: A1L4M7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEIILELQQS AQLHNREAGT QIDRQISQLV EGASGWQLWA FGCWTTIGKT    50
EMEQGQKIAH FYSTQLLLFH DLQEFYWDNY PNKLQAFYPN GALSEMKRIL 100
NVKI 104
Length:104
Mass (Da):12,149
Last modified:February 6, 2007 - v1
Checksum:i51AB6780C53DDAAA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC130602 mRNA. Translation: AAI30603.1.
BC130606 mRNA. Translation: AAI30607.1.
UniGeneiHs.473394.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC130602 mRNA. Translation: AAI30603.1 .
BC130606 mRNA. Translation: AAI30607.1 .
UniGenei Hs.473394.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC21P017443.
HGNCi HGNC:1274. LINC00478.
neXtProti NX_A1L4M7.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG130250.
InParanoidi A1L4M7.

Miscellaneous databases

ChiTaRSi LINC00478. human.

Gene expression databases

CleanExi HS_C21orf34.
Genevestigatori A1L4M7.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis."
    Gardiner K., Slavov D., Bechtel L., Davisson M.
    Genomics 79:833-843(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE PRODUCTS, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCU034_HUMAN
AccessioniPrimary (citable) accession number: A1L4M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 6, 2007
Last modified: January 22, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Product of a dubious CDS prediction. May be a non-coding RNA. Previously annotated as two separate genes based on spliced ESTs, C21orf34 and C21orf35 were shown by RT-PCR experiments to represent a single gene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM

External Data

Dasty 3

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