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A1L4M7

- CU034_HUMAN

UniProt

A1L4M7 - CU034_HUMAN

Protein

Putative uncharacterized protein encoded by LINC00478

Gene

LINC00478

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative uncharacterized protein encoded by LINC00478
    Gene namesi
    Name:LINC00478
    Synonyms:C21orf34, C21orf35
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:1274. LINC00478.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 104104Putative uncharacterized protein encoded by LINC00478PRO_0000311852Add
    BLAST

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    CleanExiHS_C21orf34.
    GenevestigatoriA1L4M7.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG130250.
    InParanoidiA1L4M7.

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: LINC00478 is composed of at least 11 exons, of which only 3 are consistently predicted by coding exon-prediction programs. Exons 3, 6, 7 and 10 are alternatively spliced, suggesting multiple transcripts can be produced. The longest possible transcript is 1300 bp, with the only significant open reading frame located in exons 1 and 2. If this indeed represents a translated product, it implies LINC00478 has an unusual 3'-UTR composed of 9 exons.

    Isoform 1 (identifier: A1L4M7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEIILELQQS AQLHNREAGT QIDRQISQLV EGASGWQLWA FGCWTTIGKT    50
    EMEQGQKIAH FYSTQLLLFH DLQEFYWDNY PNKLQAFYPN GALSEMKRIL 100
    NVKI 104
    Length:104
    Mass (Da):12,149
    Last modified:February 6, 2007 - v1
    Checksum:i51AB6780C53DDAAA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC130602 mRNA. Translation: AAI30603.1.
    BC130606 mRNA. Translation: AAI30607.1.
    UniGeneiHs.473394.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC130602 mRNA. Translation: AAI30603.1 .
    BC130606 mRNA. Translation: AAI30607.1 .
    UniGenei Hs.473394.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC21P017443.
    HGNCi HGNC:1274. LINC00478.
    neXtProti NX_A1L4M7.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG130250.
    InParanoidi A1L4M7.

    Miscellaneous databases

    ChiTaRSi LINC00478. human.

    Gene expression databases

    CleanExi HS_C21orf34.
    Genevestigatori A1L4M7.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis."
      Gardiner K., Slavov D., Bechtel L., Davisson M.
      Genomics 79:833-843(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE PRODUCTS, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCU034_HUMAN
    AccessioniPrimary (citable) accession number: A1L4M7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Product of a dubious CDS prediction. May be a non-coding RNA. Previously annotated as two separate genes based on spliced ESTs, C21orf34 and C21orf35 were shown by RT-PCR experiments to represent a single gene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM

    External Data

    Dasty 3