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Protein

Mitogen-activated protein kinase

Gene

MAPK8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseSAAS annotation (EC:2.7.11.24SAAS annotation)
Gene namesi
Name:MAPK8Imported
ORF Names:hCG_23734Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000107643.15.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA283.

Expressioni

Gene expression databases

BgeeiENSG00000107643.
ExpressionAtlasiA1L4K2. baseline and differential.

Structurei

3D structure databases

SMRiA1L4K2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 321Protein kinaseInterPro annotationAdd BLAST296

Phylogenomic databases

eggNOGiKOG0665. Eukaryota.
ENOG410XSHI. LUCA.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
KOiK04440.
OMAiYKEVLEW.
OrthoDBiEOG091G09G2.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
PRINTSiPR01772. JNKMAPKINASE.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

A1L4K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER
60 70 80 90 100
NVAIKKLSRP FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE
110 120 130 140 150
FQDVYIVMEL MDANLCQVIQ MELDHERMSY LLYQMLCGIK HLHSAGIIHR
160 170 180 190 200
DLKPSNIVVK SDCTLKILDF GLARTAGTSF MMTPYVVTRY YRAPEVILGM
210 220 230 240 250
GYKENVDIWS VGCIMGEMIK GGVLFPGTDH IDQWNKVIEQ LGTPCPEFMK
260 270 280 290 300
KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK
310 320 330 340 350
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE
360 370 380 390 400
EWKELIYKEV MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS
410 420
SMSTDPTLAS DTDSSLEAAA GPLGCCR
Length:427
Mass (Da):48,088
Last modified:February 20, 2007 - v1
Checksum:i3F5CC3F6A4F3EF2D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei427Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC130570 mRNA. Translation: AAI30571.1.
BC130572 mRNA. Translation: AAI30573.1.
AK292523 mRNA. Translation: BAF85212.1.
AB451271 mRNA. Translation: BAG70085.1.
AB451398 mRNA. Translation: BAG70212.1.
CH471187 Genomic DNA. Translation: EAW93135.1.
CH471187 Genomic DNA. Translation: EAW93138.1.
RefSeqiNP_001265476.1. NM_001278547.1.
NP_001265477.1. NM_001278548.1.
NP_001310251.1. NM_001323322.1.
NP_001310252.1. NM_001323323.1.
NP_001310259.1. NM_001323330.1.
UniGeneiHs.138211.
Hs.522924.

Genome annotation databases

GeneIDi5599.
KEGGihsa:5599.

Similar proteinsi

Entry informationi

Entry nameiA1L4K2_HUMAN
AccessioniPrimary (citable) accession number: A1L4K2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 27, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.