Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibronectin type III and SPRY domain-containing protein 2

Gene

FSD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type III and SPRY domain-containing protein 2
Alternative name(s):
SPRY domain-containing protein 1
Gene namesi
Name:FSD2
Synonyms:SPRYD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:18024. FSD2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi123722.
OpenTargetsiENSG00000186628.
PharmGKBiPA38279.

Polymorphism and mutation databases

BioMutaiFSD2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003173621 – 749Fibronectin type III and SPRY domain-containing protein 2Add BLAST749

Proteomic databases

PaxDbiA1L4K1.
PRIDEiA1L4K1.

PTM databases

iPTMnetiA1L4K1.
PhosphoSitePlusiA1L4K1.

Expressioni

Gene expression databases

BgeeiENSG00000186628.
CleanExiHS_FSD2.
ExpressionAtlasiA1L4K1. baseline and differential.
GenevisibleiA1L4K1. HS.

Organism-specific databases

HPAiHPA046263.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125831. 42 interactors.
IntActiA1L4K1. 90 interactors.
STRINGi9606.ENSP00000335651.

Structurei

3D structure databases

ProteinModelPortaliA1L4K1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini375 – 470Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini471 – 564Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94
Domaini546 – 744B30.2/SPRYPROSITE-ProRule annotationAdd BLAST199

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili205 – 317Sequence analysisAdd BLAST113

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00840000129812.
HOGENOMiHOG000112658.
HOVERGENiHBG106607.
InParanoidiA1L4K1.
OMAiKEIRSCE.
OrthoDBiEOG091G01ZK.
PhylomeDBiA1L4K1.
TreeFamiTF315216.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003877. SPRY_dom.
PfamiView protein in Pfam
PF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiView protein in SMART
SM00060. FN3. 2 hits.
SM00449. SPRY. 1 hit.
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.
PS50853. FN3. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A1L4K1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEESGEELG LDRSTPKDFH FYHMDLYDSE DRLHLFPEEN TRMRKVVQAE
60 70 80 90 100
MANESRGAGD GKAQRDLQEE VDELVHLYGL EDDHELGDEF VDENIPRTGV
110 120 130 140 150
SEYPPYMMKR RDPAREQRDW RLSGEAAEAE DLGFGGWGSA GQCQDLREAY
160 170 180 190 200
RYTHGRASEE YECYVIPEEE DEEEAADVFC VTCKTPIRAF QKVFDEHKEH
210 220 230 240 250
EVIPLNEALE SAKDEIHKNM YKLEKQIIEM ENFANHLEEV FITVEENFGK
260 270 280 290 300
QEQNFESHYN EILETLAQKY EEKIQALGEK KKEKLEALYG QLVSCGENLD
310 320 330 340 350
TCKELMETIE EMCHEEKVDF IKDAVAMADR LGKFLKTKTD VEISAQPEFE
360 370 380 390 400
DQTLDFSDVE QLMGSINTIP APSAPVINPQ VPNSATGSSV RVCWSLYSDD
410 420 430 440 450
TVESYQLSYR PVQDSSPGTD QAEFTVTVKE TYCSVTNLVP NTQYEFWVTA
460 470 480 490 500
HNRAGPSPSS ERAVYMTAPS PPIIKTKEIR SCEEAVLICW ESGNLNPVDS
510 520 530 540 550
YTVELTQAES PEASGVTESV VGIPTCESVV QLQPGRSYII YVRALNMGGP
560 570 580 590 600
SVRSEPATVH TIGSYFRLNK DTCHPWLTIS EDGLTAVRSE RRTPARELSP
610 620 630 640 650
SDTHFTRCVA VMGNLIPVRG HHYWEVEVDE HLDYRVGVAF ADVRKQEDLG
660 670 680 690 700
ANCLSWCMRH TFASSRHKYE FLHNRTTPDI RITVPPKKIG ILLDYEHSKL
710 720 730 740
SFFNVDLSQH LYTFSCQLHE FVHPCFSLEK PGCLKVHNGI SMPKHVTFY
Length:749
Mass (Da):85,385
Last modified:February 6, 2007 - v1
Checksum:iA4AFC0677A4FE38B
GO
Isoform 2 (identifier: A1L4K1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-467: Missing.

Note: No experimental confirmation available.
Show »
Length:704
Mass (Da):80,291
Checksum:i43BB59195155712A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051001333K → T. Corresponds to variant dbSNP:rs4779061Ensembl.1
Natural variantiVAR_051002720E → K. Corresponds to variant dbSNP:rs1108134Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054600423 – 467Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122875 mRNA. Translation: BAG53773.1.
AC044907 Genomic DNA. No translation available.
AC105339 Genomic DNA. No translation available.
BC130569 mRNA. Translation: AAI30570.1.
BC144175 mRNA. Translation: AAI44176.1.
CCDSiCCDS45332.1. [A1L4K1-1]
CCDS61738.1. [A1L4K1-2]
RefSeqiNP_001007123.1. NM_001007122.3. [A1L4K1-1]
NP_001268734.1. NM_001281805.1. [A1L4K1-2]
NP_001268735.1. NM_001281806.1. [A1L4K1-2]
XP_005272482.1. XM_005272425.4. [A1L4K1-1]
UniGeneiHs.719372.

Genome annotation databases

EnsembliENST00000334574; ENSP00000335651; ENSG00000186628. [A1L4K1-1]
ENST00000541889; ENSP00000444078; ENSG00000186628. [A1L4K1-2]
GeneIDi123722.
KEGGihsa:123722.
UCSCiuc002bjd.4. human. [A1L4K1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFSD2_HUMAN
AccessioniPrimary (citable) accession number: A1L4K1
Secondary accession number(s): B3KVG1, B7ZM02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: June 7, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations