Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibronectin type III and SPRY domain-containing protein 2

Gene

FSD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type III and SPRY domain-containing protein 2
Alternative name(s):
SPRY domain-containing protein 1
Gene namesi
Name:FSD2
Synonyms:SPRYD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:18024. FSD2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38279.

Polymorphism and mutation databases

BioMutaiFSD2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Fibronectin type III and SPRY domain-containing protein 2PRO_0000317362Add
BLAST

Proteomic databases

PaxDbiA1L4K1.
PRIDEiA1L4K1.

PTM databases

PhosphoSiteiA1L4K1.

Expressioni

Gene expression databases

BgeeiA1L4K1.
CleanExiHS_FSD2.
ExpressionAtlasiA1L4K1. baseline and differential.
GenevisibleiA1L4K1. HS.

Organism-specific databases

HPAiHPA048450.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9H6F03EBI-5661036,EBI-10307481
AESQ081173EBI-5661036,EBI-717810
AQP1P299723EBI-5661036,EBI-745213
BEX2Q9BXY83EBI-5661036,EBI-745073
BRD8Q9H0E9-23EBI-5661036,EBI-10304361
CBX8Q9HC523EBI-5661036,EBI-712912
CCDC112Q8NEF33EBI-5661036,EBI-745040
CCHCR1Q8TD31-33EBI-5661036,EBI-10175300
CDC73Q6P1J95EBI-5661036,EBI-930143
CORO1AP311463EBI-5661036,EBI-1046676
ESDP107683EBI-5661036,EBI-1052334
FAM107AO95990-33EBI-5661036,EBI-10192902
FAM161AQ3B8203EBI-5661036,EBI-719941
FAM90A1Q86YD73EBI-5661036,EBI-6658203
FMR1Q06787-83EBI-5661036,EBI-10224470
IFT20Q8IY313EBI-5661036,EBI-744203
KANSL1I3L4J33EBI-5661036,EBI-10178305
LATS1Q6PJG33EBI-5661036,EBI-10253976
LENG1Q96BZ83EBI-5661036,EBI-726510
MRPL11Q9Y3B73EBI-5661036,EBI-5453723
NGFRAP1Q009943EBI-5661036,EBI-741753
PBX3Q5JS983EBI-5661036,EBI-10244393
PIK3R3Q8N3813EBI-5661036,EBI-749096
POLLQ9UGP5-24EBI-5661036,EBI-10320765
PPP1R18Q6NYC83EBI-5661036,EBI-2557469
PPP2R5DQ147383EBI-5661036,EBI-396563
PSMB4P280703EBI-5661036,EBI-603350
SH2D4AQ9H7883EBI-5661036,EBI-747035
SH2D4AQ9H788-23EBI-5661036,EBI-10308083
SPATC1LQ9H0A94EBI-5661036,EBI-372911
TCEANCQ8N8B73EBI-5661036,EBI-954696
ZC2HC1CQ53FD03EBI-5661036,EBI-740767
ZMAT2Q96NC03EBI-5661036,EBI-2682299
ZNF124Q159733EBI-5661036,EBI-2555767
ZNF20P170243EBI-5661036,EBI-717634
ZNF230Q9UIE03EBI-5661036,EBI-1105361
ZNF410Q86VK43EBI-5661036,EBI-720304
ZNF417Q8TAU33EBI-5661036,EBI-740727
ZNF572A1L4E93EBI-5661036,EBI-10172590
ZNF572Q7Z3I74EBI-5661036,EBI-10257016
ZNF581Q9P0T43EBI-5661036,EBI-745520
ZNF587Q96SQ53EBI-5661036,EBI-6427977
ZSCAN26Q166703EBI-5661036,EBI-3920053

Protein-protein interaction databases

BioGridi125831. 42 interactions.
IntActiA1L4K1. 43 interactions.
STRINGi9606.ENSP00000335651.

Structurei

3D structure databases

ProteinModelPortaliA1L4K1.
SMRiA1L4K1. Positions 365-561, 568-728.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini375 – 47096Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini471 – 56494Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini546 – 744199B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili205 – 317113Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00840000129812.
HOGENOMiHOG000112658.
HOVERGENiHBG106607.
InParanoidiA1L4K1.
OMAiYTVELTQ.
OrthoDBiEOG79GT5T.
PhylomeDBiA1L4K1.
TreeFamiTF315216.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00060. FN3. 2 hits.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50853. FN3. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A1L4K1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEESGEELG LDRSTPKDFH FYHMDLYDSE DRLHLFPEEN TRMRKVVQAE
60 70 80 90 100
MANESRGAGD GKAQRDLQEE VDELVHLYGL EDDHELGDEF VDENIPRTGV
110 120 130 140 150
SEYPPYMMKR RDPAREQRDW RLSGEAAEAE DLGFGGWGSA GQCQDLREAY
160 170 180 190 200
RYTHGRASEE YECYVIPEEE DEEEAADVFC VTCKTPIRAF QKVFDEHKEH
210 220 230 240 250
EVIPLNEALE SAKDEIHKNM YKLEKQIIEM ENFANHLEEV FITVEENFGK
260 270 280 290 300
QEQNFESHYN EILETLAQKY EEKIQALGEK KKEKLEALYG QLVSCGENLD
310 320 330 340 350
TCKELMETIE EMCHEEKVDF IKDAVAMADR LGKFLKTKTD VEISAQPEFE
360 370 380 390 400
DQTLDFSDVE QLMGSINTIP APSAPVINPQ VPNSATGSSV RVCWSLYSDD
410 420 430 440 450
TVESYQLSYR PVQDSSPGTD QAEFTVTVKE TYCSVTNLVP NTQYEFWVTA
460 470 480 490 500
HNRAGPSPSS ERAVYMTAPS PPIIKTKEIR SCEEAVLICW ESGNLNPVDS
510 520 530 540 550
YTVELTQAES PEASGVTESV VGIPTCESVV QLQPGRSYII YVRALNMGGP
560 570 580 590 600
SVRSEPATVH TIGSYFRLNK DTCHPWLTIS EDGLTAVRSE RRTPARELSP
610 620 630 640 650
SDTHFTRCVA VMGNLIPVRG HHYWEVEVDE HLDYRVGVAF ADVRKQEDLG
660 670 680 690 700
ANCLSWCMRH TFASSRHKYE FLHNRTTPDI RITVPPKKIG ILLDYEHSKL
710 720 730 740
SFFNVDLSQH LYTFSCQLHE FVHPCFSLEK PGCLKVHNGI SMPKHVTFY
Length:749
Mass (Da):85,385
Last modified:February 6, 2007 - v1
Checksum:iA4AFC0677A4FE38B
GO
Isoform 2 (identifier: A1L4K1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-467: Missing.

Note: No experimental confirmation available.
Show »
Length:704
Mass (Da):80,291
Checksum:i43BB59195155712A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti333 – 3331K → T.
Corresponds to variant rs4779061 [ dbSNP | Ensembl ].
VAR_051001
Natural varianti720 – 7201E → K.
Corresponds to variant rs1108134 [ dbSNP | Ensembl ].
VAR_051002

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei423 – 46745Missing in isoform 2. 1 PublicationVSP_054600Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122875 mRNA. Translation: BAG53773.1.
AC044907 Genomic DNA. No translation available.
AC105339 Genomic DNA. No translation available.
BC130569 mRNA. Translation: AAI30570.1.
BC144175 mRNA. Translation: AAI44176.1.
CCDSiCCDS45332.1. [A1L4K1-1]
CCDS61738.1. [A1L4K1-2]
RefSeqiNP_001007123.1. NM_001007122.3. [A1L4K1-1]
NP_001268734.1. NM_001281805.1. [A1L4K1-2]
NP_001268735.1. NM_001281806.1. [A1L4K1-2]
XP_005272482.1. XM_005272425.3. [A1L4K1-1]
XP_005272483.1. XM_005272426.3. [A1L4K1-1]
XP_011519536.1. XM_011521234.1. [A1L4K1-1]
UniGeneiHs.719372.

Genome annotation databases

EnsembliENST00000334574; ENSP00000335651; ENSG00000186628. [A1L4K1-1]
ENST00000541889; ENSP00000444078; ENSG00000186628. [A1L4K1-2]
GeneIDi123722.
KEGGihsa:123722.
UCSCiuc002bjd.4. human. [A1L4K1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122875 mRNA. Translation: BAG53773.1.
AC044907 Genomic DNA. No translation available.
AC105339 Genomic DNA. No translation available.
BC130569 mRNA. Translation: AAI30570.1.
BC144175 mRNA. Translation: AAI44176.1.
CCDSiCCDS45332.1. [A1L4K1-1]
CCDS61738.1. [A1L4K1-2]
RefSeqiNP_001007123.1. NM_001007122.3. [A1L4K1-1]
NP_001268734.1. NM_001281805.1. [A1L4K1-2]
NP_001268735.1. NM_001281806.1. [A1L4K1-2]
XP_005272482.1. XM_005272425.3. [A1L4K1-1]
XP_005272483.1. XM_005272426.3. [A1L4K1-1]
XP_011519536.1. XM_011521234.1. [A1L4K1-1]
UniGeneiHs.719372.

3D structure databases

ProteinModelPortaliA1L4K1.
SMRiA1L4K1. Positions 365-561, 568-728.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125831. 42 interactions.
IntActiA1L4K1. 43 interactions.
STRINGi9606.ENSP00000335651.

PTM databases

PhosphoSiteiA1L4K1.

Polymorphism and mutation databases

BioMutaiFSD2.

Proteomic databases

PaxDbiA1L4K1.
PRIDEiA1L4K1.

Protocols and materials databases

DNASUi123722.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334574; ENSP00000335651; ENSG00000186628. [A1L4K1-1]
ENST00000541889; ENSP00000444078; ENSG00000186628. [A1L4K1-2]
GeneIDi123722.
KEGGihsa:123722.
UCSCiuc002bjd.4. human. [A1L4K1-1]

Organism-specific databases

CTDi123722.
GeneCardsiFSD2.
HGNCiHGNC:18024. FSD2.
HPAiHPA048450.
neXtProtiNX_A1L4K1.
PharmGKBiPA38279.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00840000129812.
HOGENOMiHOG000112658.
HOVERGENiHBG106607.
InParanoidiA1L4K1.
OMAiYTVELTQ.
OrthoDBiEOG79GT5T.
PhylomeDBiA1L4K1.
TreeFamiTF315216.

Miscellaneous databases

GenomeRNAii123722.
NextBioi35481356.
PROiA1L4K1.

Gene expression databases

BgeeiA1L4K1.
CleanExiHS_FSD2.
ExpressionAtlasiA1L4K1. baseline and differential.
GenevisibleiA1L4K1. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00060. FN3. 2 hits.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Heart.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiFSD2_HUMAN
AccessioniPrimary (citable) accession number: A1L4K1
Secondary accession number(s): B3KVG1, B7ZM02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.