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A1L4H1 (SRCRL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
Alternative name(s):
Soluble scavenger protein with 5 SRCR domains
Short name=SSc5D
Gene names
Name:SSC5D
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1573 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces By similarity.

Subunit structure

Interacts with LGALS1 and laminin By similarity.

Subcellular location

Secreted By similarity. Cytoplasm By similarity.

Tissue specificity

Highly expressed in monocytes/macrophages and T-lymphocytes. Highly expressed in placenta and spleen, and also detected at lower levels in colon, and more weakly in lung, heart and kidney. Ref.1

Sequence similarities

Contains 5 SRCR domains.

Sequence caution

The sequence AAI30539.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAI30541.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processImmunity
Innate immunity
   Cellular componentCytoplasm
Secreted
   Coding sequence diversityAlternative splicing
   DomainRepeat
Signal
   Molecular functionDevelopmental protein
Receptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdetection of bacterial lipoprotein

Inferred from sequence or structural similarity. Source: UniProtKB

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of interleukin-8 secretion

Inferred from sequence or structural similarity. Source: UniProtKB

receptor-mediated endocytosis

Inferred from sequence or structural similarity. Source: GOC

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular matrix

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functionextracellular matrix binding

Inferred from sequence or structural similarity. Source: UniProtKB

fibronectin binding

Inferred from sequence or structural similarity. Source: UniProtKB

laminin binding

Inferred from sequence or structural similarity. Source: UniProtKB

scavenger receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A1L4H1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A1L4H1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     929-953: GSKDGYKLPWTWDTPSGRGLAEGTP → EPEAGVREVMLLVQGLPGLQRLPSP
     954-1573: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 15731557Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
PRO_0000332985

Regions

Domain20 – 120101SRCR 1
Domain198 – 298101SRCR 2
Domain304 – 404101SRCR 3
Domain467 – 568102SRCR 4
Domain772 – 872101SRCR 5
Compositional bias616 – 729114Thr-rich
Compositional bias970 – 1488519Pro-rich
Compositional bias1089 – 1382294Thr-rich
Compositional bias1558 – 15614Poly-Thr
Compositional bias1563 – 15664Poly-Glu

Amino acid modifications

Glycosylation1681N-linked (GlcNAc...) Potential
Glycosylation3761N-linked (GlcNAc...) Potential
Glycosylation4201N-linked (GlcNAc...) Potential
Disulfide bond45 ↔ 109 By similarity
Disulfide bond58 ↔ 119 By similarity
Disulfide bond89 ↔ 99 By similarity
Disulfide bond223 ↔ 287 By similarity
Disulfide bond236 ↔ 297 By similarity
Disulfide bond267 ↔ 277 By similarity
Disulfide bond329 ↔ 393 By similarity
Disulfide bond342 ↔ 403 By similarity
Disulfide bond373 ↔ 383 By similarity
Disulfide bond492 ↔ 557 By similarity
Disulfide bond505 ↔ 567 By similarity
Disulfide bond537 ↔ 547 By similarity
Disulfide bond797 ↔ 861 By similarity
Disulfide bond810 ↔ 871 By similarity
Disulfide bond841 ↔ 851 By similarity

Natural variations

Alternative sequence929 – 95325GSKDG…AEGTP → EPEAGVREVMLLVQGLPGLQ RLPSP in isoform 2.
VSP_040792
Alternative sequence954 – 1573620Missing in isoform 2.
VSP_040793

Experimental info

Sequence conflict9761L → P in ACJ02751. Ref.1
Sequence conflict12741M → I in ACJ02751. Ref.1
Sequence conflict14561P → S in ACJ02751. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 5, 2011. Version 3.
Checksum: 9151F14B58BD1A0D

FASTA1,573165,743
        10         20         30         40         50         60 
MRVLACLLAA LVGIQAVERL RLADGPHGCA GRLEVWHGGR WGTVCDDGWD LRDAAVACRQ 

        70         80         90        100        110        120 
LGCGGALAAP GGAFFGEGAG PVWLSELACR GNEGQLGLCH HRGWKAHICS HEEDAGVVCA 

       130        140        150        160        170        180 
GQRVANSRDD STSPLDGAPW PGLLLELSPS TEEPLVTHAP RPAGNPQNAS RKKSPRPKQA 

       190        200        210        220        230        240 
KSTRAPLLTT GAPRQERLRL VSGPHRCAGR LEVWHGGRWG TVCDDGWDLR DAAVACRELG 

       250        260        270        280        290        300 
CGGALAAPGG ARFGPGAGPV WMDDVGCGGG EQALRDCPRS PWGRSNCDHS EDAGLVCTGP 

       310        320        330        340        350        360 
APRLRLADGP HGCAGRLEVW HGGRWGSVCD DAWDLRDAAV ACRELGCGGA LAAPGGAFFG 

       370        380        390        400        410        420 
EGSGPIILDD LRCRGNETAL RFCPARPWGQ HDCHHREDAG AVCDGMPLGY VPPTAPTDSN 

       430        440        450        460        470        480 
NSTPREAASR PPSTMTSQAP GTAGVSPPPA SPTVLWEPGP EAGSPQLRLV AGPSKCSGRL 

       490        500        510        520        530        540 
EVWHDQRWGT VCDDSWDMRD SAVVCRELGC GGPQQPDPAA GRFGWGAGPI WLDDVGCVGT 

       550        560        570        580        590        600 
EASLSDCPAA PWGKHNCAHN EDVGVTCTGP PGLDSISDPF SWSWIPGLGR DRDAWLPGEL 

       610        620        630        640        650        660 
ATKPSASVTA SVLEKTTTKA PGKMPKSTKK WVTKNAKRPT TQPPVMPTTK HSRAQSPPDL 

       670        680        690        700        710        720 
TSQTTAALTT EASRRPTSEF TRRPTTEAPQ RWTSHTTATL TPQAPRERTT KTMAMLTTQG 

       730        740        750        760        770        780 
PQEMTSESTI KSIPQASLEP SAEIPEGSPE SPKDPAPSPS VSTTGESGLF RVRLADGPNR 

       790        800        810        820        830        840 
CAGRLEVWHA GRWGTVCDDN WDLRDATVAC WELGCGKVRP RVGKTHYGPG TGPIWLDDMG 

       850        860        870        880        890        900 
CKGSEASLSD CPSGAWGKHN CDHEEDVGLT CTGYTDYDDY PPWTWDPTSR EDLAKGTTTA 

       910        920        930        940        950        960 
GVPGHTLPWR TTRRPGSSSP AIRRLPDTGS KDGYKLPWTW DTPSGRGLAE GTPTAGKLGP 

       970        980        990       1000       1010       1020 
TLGAGTTRSP GSPPTLRVHG DTGSPRKPWP ERRPPRPAAT RTAPPTPSPG PSASPGPPGP 

      1030       1040       1050       1060       1070       1080 
ALTSDSSREL TPHSALTSEA TSDAPDTSPP TPDPASRTNP DLILTSPDFA LSTPDSSVVP 

      1090       1100       1110       1120       1130       1140 
ALTPEPSPTP LPTLPKELTS DPSTPSEVTS LSPTSEQVPE SDTTPDLDTT PYSSTVSEYS 

      1150       1160       1170       1180       1190       1200 
RSPDPSPSPH PTTTPDPTMA PDPITTLNPT VTPHFPTTPH PTTTPHPTTI THSTMIPDPT 

      1210       1220       1230       1240       1250       1260 
TTPQPFTTIT HSTMIPDPTT TPQPFTTMQP TTTPHSTTPH PTTTPHPTTI THSTMIPDPT 

      1270       1280       1290       1300       1310       1320 
TTPQPFTTMQ PTTMPHPTTT PHPTTTPHPT TTPHPTTTPH PTMTPDPTTT PYPTTTPDPT 

      1330       1340       1350       1360       1370       1380 
TTPHPTTPDP SSTPVITTVS LPTSLGTELS SPTLAPTVKP SLHPQLTFTA PAPHTSTSQI 

      1390       1400       1410       1420       1430       1440 
PTLEPSPALE SSPSRSSTAT SMDPLSTEDF KPPRSQSPNL TPPPTHTPHS ASDLTVSPDP 

      1450       1460       1470       1480       1490       1500 
LLSPTAHPLD HPPLDPLTLG PTPGQSPGPH GPCVAPTPPV RVMACEPPAL VELVAAVRDV 

      1510       1520       1530       1540       1550       1560 
GGQLQRLTQV VEQERQERQA LLLGLTQLVE AARGLGQLGE AVKRLAEMAW TTSMPAPTTT 

      1570 
TPEEEERPLR GDV 

« Hide

Isoform 2 [UniParc].

Checksum: 9E39E2FD892F72CF
Show »

FASTA953100,918

References

« Hide 'large scale' references
[1]"Molecular cloning and analysis of SSc5D, a new member of the scavenger receptor cysteine-rich superfamily."
Goncalves C.M., Castro M.A., Henriques T., Oliveira M.I., Pinheiro H.C., Oliveira C., Sreenu V.B., Evans E.J., Davis S.J., Moreira A., Carmo A.M.
Mol. Immunol. 46:2585-2596(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1475-1573 (ISOFORM 1).
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EU699476 mRNA. Translation: ACJ02751.1.
EU699477 mRNA. Translation: ACJ02752.1.
AC008735 Genomic DNA. No translation available.
BC130538 mRNA. Translation: AAI30539.1. Different initiation.
BC130540 mRNA. Translation: AAI30541.1. Different initiation.
RefSeqNP_001138422.1. NM_001144950.1.
NP_001182196.1. NM_001195267.1.
UniGeneHs.554182.

3D structure databases

ProteinModelPortalA1L4H1.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA1L4H1.

Proteomic databases

PaxDbA1L4H1.
PRIDEA1L4H1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000389623; ENSP00000374274; ENSG00000179954. [A1L4H1-1]
GeneID284297.
KEGGhsa:284297.
UCSCuc002qlg.4. human. [A1L4H1-1]
uc021vbw.1. human. [A1L4H1-2]

Organism-specific databases

CTD284297.
GeneCardsGC19P055999.
H-InvDBHIX0015472.
HGNCHGNC:26641. SSC5D.
HPAHPA042008.
neXtProtNX_A1L4H1.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149171.
HOGENOMHOG000154412.
HOVERGENHBG108511.
OMAPVRVMAC.
PhylomeDBA1L4H1.
TreeFamTF329295.

Gene expression databases

ArrayExpressA1L4H1.
BgeeA1L4H1.
GenevestigatorA1L4H1.

Family and domain databases

Gene3D3.10.250.10. 5 hits.
InterProIPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamPF00530. SRCR. 5 hits.
[Graphical view]
PRINTSPR00258. SPERACTRCPTR.
SMARTSM00202. SR. 5 hits.
[Graphical view]
SUPFAMSSF56487. SSF56487. 5 hits.
PROSITEPS00420. SRCR_1. 5 hits.
PS50287. SRCR_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi284297.
NextBio94704.
PROA1L4H1.

Entry information

Entry nameSRCRL_HUMAN
AccessionPrimary (citable) accession number: A1L4H1
Secondary accession number(s): B5MDQ5, C7S7T9, C7S7U0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 5, 2011
Last modified: April 16, 2014
This is version 54 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM