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A1L4H1

- SRCRL_HUMAN

UniProt

A1L4H1 - SRCRL_HUMAN

Protein

Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Gene

SSC5D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 3 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces By similarity.By similarity

    GO - Molecular functioni

    1. extracellular matrix binding Source: UniProtKB
    2. fibronectin binding Source: UniProtKB
    3. laminin binding Source: UniProtKB
    4. scavenger receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of bacterial lipoprotein Source: UniProtKB
    2. innate immune response Source: UniProtKB-KW
    3. multicellular organismal development Source: UniProtKB-KW
    4. negative regulation of interleukin-8 secretion Source: UniProtKB
    5. receptor-mediated endocytosis Source: GOC

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Immunity, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
    Alternative name(s):
    Soluble scavenger protein with 5 SRCR domains
    Short name:
    SSc5D
    Gene namesi
    Name:SSC5D
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:26641. SSC5D.

    Subcellular locationi

    Secreted By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular matrix Source: UniProtKB
    3. extracellular space Source: UniProtKB
    4. intracellular Source: UniProtKB
    5. membrane Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 15731557Soluble scavenger receptor cysteine-rich domain-containing protein SSC5DPRO_0000332985Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi45 ↔ 109PROSITE-ProRule annotation
    Disulfide bondi58 ↔ 119PROSITE-ProRule annotation
    Disulfide bondi89 ↔ 99PROSITE-ProRule annotation
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi223 ↔ 287PROSITE-ProRule annotation
    Disulfide bondi236 ↔ 297PROSITE-ProRule annotation
    Disulfide bondi267 ↔ 277PROSITE-ProRule annotation
    Disulfide bondi329 ↔ 393PROSITE-ProRule annotation
    Disulfide bondi342 ↔ 403PROSITE-ProRule annotation
    Disulfide bondi373 ↔ 383PROSITE-ProRule annotation
    Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi492 ↔ 557PROSITE-ProRule annotation
    Disulfide bondi505 ↔ 567PROSITE-ProRule annotation
    Disulfide bondi537 ↔ 547PROSITE-ProRule annotation
    Disulfide bondi797 ↔ 861PROSITE-ProRule annotation
    Disulfide bondi810 ↔ 871PROSITE-ProRule annotation
    Disulfide bondi841 ↔ 851PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiA1L4H1.
    PRIDEiA1L4H1.

    PTM databases

    PhosphoSiteiA1L4H1.

    Expressioni

    Tissue specificityi

    Highly expressed in monocytes/macrophages and T-lymphocytes. Highly expressed in placenta and spleen, and also detected at lower levels in colon, and more weakly in lung, heart and kidney.1 Publication

    Gene expression databases

    ArrayExpressiA1L4H1.
    BgeeiA1L4H1.
    GenevestigatoriA1L4H1.

    Organism-specific databases

    HPAiHPA042008.

    Interactioni

    Subunit structurei

    Interacts with LGALS1 and laminin.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA1L4H1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 120101SRCR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini198 – 298101SRCR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini304 – 404101SRCR 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini467 – 568102SRCR 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini772 – 872101SRCR 5PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi616 – 729114Thr-richAdd
    BLAST
    Compositional biasi970 – 1488519Pro-richAdd
    BLAST
    Compositional biasi1089 – 1382294Thr-richAdd
    BLAST
    Compositional biasi1558 – 15614Poly-Thr
    Compositional biasi1563 – 15664Poly-Glu

    Sequence similaritiesi

    Contains 5 SRCR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG149171.
    HOGENOMiHOG000154412.
    HOVERGENiHBG108511.
    OMAiPVRVMAC.
    PhylomeDBiA1L4H1.
    TreeFamiTF329295.

    Family and domain databases

    Gene3Di3.10.250.10. 5 hits.
    InterProiIPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    [Graphical view]
    PfamiPF00530. SRCR. 5 hits.
    [Graphical view]
    PRINTSiPR00258. SPERACTRCPTR.
    SMARTiSM00202. SR. 5 hits.
    [Graphical view]
    SUPFAMiSSF56487. SSF56487. 5 hits.
    PROSITEiPS00420. SRCR_1. 5 hits.
    PS50287. SRCR_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A1L4H1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRVLACLLAA LVGIQAVERL RLADGPHGCA GRLEVWHGGR WGTVCDDGWD     50
    LRDAAVACRQ LGCGGALAAP GGAFFGEGAG PVWLSELACR GNEGQLGLCH 100
    HRGWKAHICS HEEDAGVVCA GQRVANSRDD STSPLDGAPW PGLLLELSPS 150
    TEEPLVTHAP RPAGNPQNAS RKKSPRPKQA KSTRAPLLTT GAPRQERLRL 200
    VSGPHRCAGR LEVWHGGRWG TVCDDGWDLR DAAVACRELG CGGALAAPGG 250
    ARFGPGAGPV WMDDVGCGGG EQALRDCPRS PWGRSNCDHS EDAGLVCTGP 300
    APRLRLADGP HGCAGRLEVW HGGRWGSVCD DAWDLRDAAV ACRELGCGGA 350
    LAAPGGAFFG EGSGPIILDD LRCRGNETAL RFCPARPWGQ HDCHHREDAG 400
    AVCDGMPLGY VPPTAPTDSN NSTPREAASR PPSTMTSQAP GTAGVSPPPA 450
    SPTVLWEPGP EAGSPQLRLV AGPSKCSGRL EVWHDQRWGT VCDDSWDMRD 500
    SAVVCRELGC GGPQQPDPAA GRFGWGAGPI WLDDVGCVGT EASLSDCPAA 550
    PWGKHNCAHN EDVGVTCTGP PGLDSISDPF SWSWIPGLGR DRDAWLPGEL 600
    ATKPSASVTA SVLEKTTTKA PGKMPKSTKK WVTKNAKRPT TQPPVMPTTK 650
    HSRAQSPPDL TSQTTAALTT EASRRPTSEF TRRPTTEAPQ RWTSHTTATL 700
    TPQAPRERTT KTMAMLTTQG PQEMTSESTI KSIPQASLEP SAEIPEGSPE 750
    SPKDPAPSPS VSTTGESGLF RVRLADGPNR CAGRLEVWHA GRWGTVCDDN 800
    WDLRDATVAC WELGCGKVRP RVGKTHYGPG TGPIWLDDMG CKGSEASLSD 850
    CPSGAWGKHN CDHEEDVGLT CTGYTDYDDY PPWTWDPTSR EDLAKGTTTA 900
    GVPGHTLPWR TTRRPGSSSP AIRRLPDTGS KDGYKLPWTW DTPSGRGLAE 950
    GTPTAGKLGP TLGAGTTRSP GSPPTLRVHG DTGSPRKPWP ERRPPRPAAT 1000
    RTAPPTPSPG PSASPGPPGP ALTSDSSREL TPHSALTSEA TSDAPDTSPP 1050
    TPDPASRTNP DLILTSPDFA LSTPDSSVVP ALTPEPSPTP LPTLPKELTS 1100
    DPSTPSEVTS LSPTSEQVPE SDTTPDLDTT PYSSTVSEYS RSPDPSPSPH 1150
    PTTTPDPTMA PDPITTLNPT VTPHFPTTPH PTTTPHPTTI THSTMIPDPT 1200
    TTPQPFTTIT HSTMIPDPTT TPQPFTTMQP TTTPHSTTPH PTTTPHPTTI 1250
    THSTMIPDPT TTPQPFTTMQ PTTMPHPTTT PHPTTTPHPT TTPHPTTTPH 1300
    PTMTPDPTTT PYPTTTPDPT TTPHPTTPDP SSTPVITTVS LPTSLGTELS 1350
    SPTLAPTVKP SLHPQLTFTA PAPHTSTSQI PTLEPSPALE SSPSRSSTAT 1400
    SMDPLSTEDF KPPRSQSPNL TPPPTHTPHS ASDLTVSPDP LLSPTAHPLD 1450
    HPPLDPLTLG PTPGQSPGPH GPCVAPTPPV RVMACEPPAL VELVAAVRDV 1500
    GGQLQRLTQV VEQERQERQA LLLGLTQLVE AARGLGQLGE AVKRLAEMAW 1550
    TTSMPAPTTT TPEEEERPLR GDV 1573
    Length:1,573
    Mass (Da):165,743
    Last modified:April 5, 2011 - v3
    Checksum:i9151F14B58BD1A0D
    GO
    Isoform 2 (identifier: A1L4H1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         929-953: GSKDGYKLPWTWDTPSGRGLAEGTP → EPEAGAPRGDAPRSRTARVAAPP
         954-1573: Missing.

    Show »
    Length:951
    Mass (Da):100,561
    Checksum:iDE1008BB0541B78C
    GO

    Sequence cautioni

    The sequence ACJ02752.1 differs from that shown. Reason: Frameshift at position 934.
    The sequence AAI30539.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAI30541.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti976 – 9761L → P in ACJ02751. (PubMed:19535143)Curated
    Sequence conflicti1274 – 12741M → I in ACJ02751. (PubMed:19535143)Curated
    Sequence conflicti1456 – 14561P → S in ACJ02751. (PubMed:19535143)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei929 – 95325GSKDG…AEGTP → EPEAGAPRGDAPRSRTARVA APP in isoform 2. 1 PublicationVSP_040792Add
    BLAST
    Alternative sequencei954 – 1573620Missing in isoform 2. 1 PublicationVSP_040793Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU699476 mRNA. Translation: ACJ02751.1.
    EU699477 mRNA. Translation: ACJ02752.1. Frameshift.
    AC008735 Genomic DNA. No translation available.
    BC130538 mRNA. Translation: AAI30539.1. Different initiation.
    BC130540 mRNA. Translation: AAI30541.1. Different initiation.
    CCDSiCCDS46196.1. [A1L4H1-1]
    CCDS59424.1. [A1L4H1-2]
    RefSeqiNP_001138422.1. NM_001144950.1. [A1L4H1-1]
    NP_001182196.1. NM_001195267.1. [A1L4H1-2]
    UniGeneiHs.554182.

    Genome annotation databases

    EnsembliENST00000389623; ENSP00000374274; ENSG00000179954. [A1L4H1-1]
    ENST00000587166; ENSP00000467252; ENSG00000179954. [A1L4H1-2]
    GeneIDi284297.
    KEGGihsa:284297.
    UCSCiuc002qlg.4. human. [A1L4H1-1]
    uc021vbw.1. human. [A1L4H1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU699476 mRNA. Translation: ACJ02751.1 .
    EU699477 mRNA. Translation: ACJ02752.1 . Frameshift.
    AC008735 Genomic DNA. No translation available.
    BC130538 mRNA. Translation: AAI30539.1 . Different initiation.
    BC130540 mRNA. Translation: AAI30541.1 . Different initiation.
    CCDSi CCDS46196.1. [A1L4H1-1 ]
    CCDS59424.1. [A1L4H1-2 ]
    RefSeqi NP_001138422.1. NM_001144950.1. [A1L4H1-1 ]
    NP_001182196.1. NM_001195267.1. [A1L4H1-2 ]
    UniGenei Hs.554182.

    3D structure databases

    ProteinModelPortali A1L4H1.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A1L4H1.

    Proteomic databases

    PaxDbi A1L4H1.
    PRIDEi A1L4H1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000389623 ; ENSP00000374274 ; ENSG00000179954 . [A1L4H1-1 ]
    ENST00000587166 ; ENSP00000467252 ; ENSG00000179954 . [A1L4H1-2 ]
    GeneIDi 284297.
    KEGGi hsa:284297.
    UCSCi uc002qlg.4. human. [A1L4H1-1 ]
    uc021vbw.1. human. [A1L4H1-2 ]

    Organism-specific databases

    CTDi 284297.
    GeneCardsi GC19P055999.
    H-InvDB HIX0015472.
    HGNCi HGNC:26641. SSC5D.
    HPAi HPA042008.
    neXtProti NX_A1L4H1.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149171.
    HOGENOMi HOG000154412.
    HOVERGENi HBG108511.
    OMAi PVRVMAC.
    PhylomeDBi A1L4H1.
    TreeFami TF329295.

    Miscellaneous databases

    GenomeRNAii 284297.
    NextBioi 94704.
    PROi A1L4H1.

    Gene expression databases

    ArrayExpressi A1L4H1.
    Bgeei A1L4H1.
    Genevestigatori A1L4H1.

    Family and domain databases

    Gene3Di 3.10.250.10. 5 hits.
    InterProi IPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    [Graphical view ]
    Pfami PF00530. SRCR. 5 hits.
    [Graphical view ]
    PRINTSi PR00258. SPERACTRCPTR.
    SMARTi SM00202. SR. 5 hits.
    [Graphical view ]
    SUPFAMi SSF56487. SSF56487. 5 hits.
    PROSITEi PS00420. SRCR_1. 5 hits.
    PS50287. SRCR_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and analysis of SSc5D, a new member of the scavenger receptor cysteine-rich superfamily."
      Goncalves C.M., Castro M.A., Henriques T., Oliveira M.I., Pinheiro H.C., Oliveira C., Sreenu V.B., Evans E.J., Davis S.J., Moreira A., Carmo A.M.
      Mol. Immunol. 46:2585-2596(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1475-1573 (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiSRCRL_HUMAN
    AccessioniPrimary (citable) accession number: A1L4H1
    Secondary accession number(s): B5MDQ5
    , C7S7T9, C7S7U0, K7EP70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 59 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3