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A1L4H1

- SRCRL_HUMAN

UniProt

A1L4H1 - SRCRL_HUMAN

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Protein
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
Gene
SSC5D
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces By similarity.

GO - Molecular functioni

  1. extracellular matrix binding Source: UniProtKB
  2. fibronectin binding Source: UniProtKB
  3. laminin binding Source: UniProtKB
  4. scavenger receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of bacterial lipoprotein Source: UniProtKB
  2. innate immune response Source: UniProtKB-KW
  3. multicellular organismal development Source: UniProtKB-KW
  4. negative regulation of interleukin-8 secretion Source: UniProtKB
  5. receptor-mediated endocytosis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
Alternative name(s):
Soluble scavenger protein with 5 SRCR domains
Short name:
SSc5D
Gene namesi
Name:SSC5D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:26641. SSC5D.

Subcellular locationi

Secreted By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular matrix Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. intracellular Source: UniProtKB
  5. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 15731557Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
PRO_0000332985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 109 By similarity
Disulfide bondi58 ↔ 119 By similarity
Disulfide bondi89 ↔ 99 By similarity
Glycosylationi168 – 1681N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi223 ↔ 287 By similarity
Disulfide bondi236 ↔ 297 By similarity
Disulfide bondi267 ↔ 277 By similarity
Disulfide bondi329 ↔ 393 By similarity
Disulfide bondi342 ↔ 403 By similarity
Disulfide bondi373 ↔ 383 By similarity
Glycosylationi376 – 3761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi420 – 4201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi421 – 4211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi492 ↔ 557 By similarity
Disulfide bondi505 ↔ 567 By similarity
Disulfide bondi537 ↔ 547 By similarity
Disulfide bondi797 ↔ 861 By similarity
Disulfide bondi810 ↔ 871 By similarity
Disulfide bondi841 ↔ 851 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA1L4H1.
PRIDEiA1L4H1.

PTM databases

PhosphoSiteiA1L4H1.

Expressioni

Tissue specificityi

Highly expressed in monocytes/macrophages and T-lymphocytes. Highly expressed in placenta and spleen, and also detected at lower levels in colon, and more weakly in lung, heart and kidney.1 Publication

Gene expression databases

ArrayExpressiA1L4H1.
BgeeiA1L4H1.
GenevestigatoriA1L4H1.

Organism-specific databases

HPAiHPA042008.

Interactioni

Subunit structurei

Interacts with LGALS1 and laminin By similarity.

Structurei

3D structure databases

ProteinModelPortaliA1L4H1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 120101SRCR 1
Add
BLAST
Domaini198 – 298101SRCR 2
Add
BLAST
Domaini304 – 404101SRCR 3
Add
BLAST
Domaini467 – 568102SRCR 4
Add
BLAST
Domaini772 – 872101SRCR 5
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi616 – 729114Thr-rich
Add
BLAST
Compositional biasi970 – 1488519Pro-rich
Add
BLAST
Compositional biasi1089 – 1382294Thr-rich
Add
BLAST
Compositional biasi1558 – 15614Poly-Thr
Compositional biasi1563 – 15664Poly-Glu

Sequence similaritiesi

Contains 5 SRCR domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG149171.
HOGENOMiHOG000154412.
HOVERGENiHBG108511.
OMAiPVRVMAC.
PhylomeDBiA1L4H1.
TreeFamiTF329295.

Family and domain databases

Gene3Di3.10.250.10. 5 hits.
InterProiIPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF00530. SRCR. 5 hits.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 5 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 5 hits.
PROSITEiPS00420. SRCR_1. 5 hits.
PS50287. SRCR_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A1L4H1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRVLACLLAA LVGIQAVERL RLADGPHGCA GRLEVWHGGR WGTVCDDGWD     50
LRDAAVACRQ LGCGGALAAP GGAFFGEGAG PVWLSELACR GNEGQLGLCH 100
HRGWKAHICS HEEDAGVVCA GQRVANSRDD STSPLDGAPW PGLLLELSPS 150
TEEPLVTHAP RPAGNPQNAS RKKSPRPKQA KSTRAPLLTT GAPRQERLRL 200
VSGPHRCAGR LEVWHGGRWG TVCDDGWDLR DAAVACRELG CGGALAAPGG 250
ARFGPGAGPV WMDDVGCGGG EQALRDCPRS PWGRSNCDHS EDAGLVCTGP 300
APRLRLADGP HGCAGRLEVW HGGRWGSVCD DAWDLRDAAV ACRELGCGGA 350
LAAPGGAFFG EGSGPIILDD LRCRGNETAL RFCPARPWGQ HDCHHREDAG 400
AVCDGMPLGY VPPTAPTDSN NSTPREAASR PPSTMTSQAP GTAGVSPPPA 450
SPTVLWEPGP EAGSPQLRLV AGPSKCSGRL EVWHDQRWGT VCDDSWDMRD 500
SAVVCRELGC GGPQQPDPAA GRFGWGAGPI WLDDVGCVGT EASLSDCPAA 550
PWGKHNCAHN EDVGVTCTGP PGLDSISDPF SWSWIPGLGR DRDAWLPGEL 600
ATKPSASVTA SVLEKTTTKA PGKMPKSTKK WVTKNAKRPT TQPPVMPTTK 650
HSRAQSPPDL TSQTTAALTT EASRRPTSEF TRRPTTEAPQ RWTSHTTATL 700
TPQAPRERTT KTMAMLTTQG PQEMTSESTI KSIPQASLEP SAEIPEGSPE 750
SPKDPAPSPS VSTTGESGLF RVRLADGPNR CAGRLEVWHA GRWGTVCDDN 800
WDLRDATVAC WELGCGKVRP RVGKTHYGPG TGPIWLDDMG CKGSEASLSD 850
CPSGAWGKHN CDHEEDVGLT CTGYTDYDDY PPWTWDPTSR EDLAKGTTTA 900
GVPGHTLPWR TTRRPGSSSP AIRRLPDTGS KDGYKLPWTW DTPSGRGLAE 950
GTPTAGKLGP TLGAGTTRSP GSPPTLRVHG DTGSPRKPWP ERRPPRPAAT 1000
RTAPPTPSPG PSASPGPPGP ALTSDSSREL TPHSALTSEA TSDAPDTSPP 1050
TPDPASRTNP DLILTSPDFA LSTPDSSVVP ALTPEPSPTP LPTLPKELTS 1100
DPSTPSEVTS LSPTSEQVPE SDTTPDLDTT PYSSTVSEYS RSPDPSPSPH 1150
PTTTPDPTMA PDPITTLNPT VTPHFPTTPH PTTTPHPTTI THSTMIPDPT 1200
TTPQPFTTIT HSTMIPDPTT TPQPFTTMQP TTTPHSTTPH PTTTPHPTTI 1250
THSTMIPDPT TTPQPFTTMQ PTTMPHPTTT PHPTTTPHPT TTPHPTTTPH 1300
PTMTPDPTTT PYPTTTPDPT TTPHPTTPDP SSTPVITTVS LPTSLGTELS 1350
SPTLAPTVKP SLHPQLTFTA PAPHTSTSQI PTLEPSPALE SSPSRSSTAT 1400
SMDPLSTEDF KPPRSQSPNL TPPPTHTPHS ASDLTVSPDP LLSPTAHPLD 1450
HPPLDPLTLG PTPGQSPGPH GPCVAPTPPV RVMACEPPAL VELVAAVRDV 1500
GGQLQRLTQV VEQERQERQA LLLGLTQLVE AARGLGQLGE AVKRLAEMAW 1550
TTSMPAPTTT TPEEEERPLR GDV 1573
Length:1,573
Mass (Da):165,743
Last modified:April 5, 2011 - v3
Checksum:i9151F14B58BD1A0D
GO
Isoform 2 (identifier: A1L4H1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     929-953: GSKDGYKLPWTWDTPSGRGLAEGTP → EPEAGAPRGDAPRSRTARVAAPP
     954-1573: Missing.

Show »
Length:951
Mass (Da):100,561
Checksum:iDE1008BB0541B78C
GO

Sequence cautioni

The sequence ACJ02752.1 differs from that shown. Reason: Frameshift at position 934.
The sequence AAI30539.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAI30541.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei929 – 95325GSKDG…AEGTP → EPEAGAPRGDAPRSRTARVA APP in isoform 2.
VSP_040792Add
BLAST
Alternative sequencei954 – 1573620Missing in isoform 2.
VSP_040793Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti976 – 9761L → P in ACJ02751. 1 Publication
Sequence conflicti1274 – 12741M → I in ACJ02751. 1 Publication
Sequence conflicti1456 – 14561P → S in ACJ02751. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU699476 mRNA. Translation: ACJ02751.1.
EU699477 mRNA. Translation: ACJ02752.1. Frameshift.
AC008735 Genomic DNA. No translation available.
BC130538 mRNA. Translation: AAI30539.1. Different initiation.
BC130540 mRNA. Translation: AAI30541.1. Different initiation.
CCDSiCCDS46196.1. [A1L4H1-1]
CCDS59424.1. [A1L4H1-2]
RefSeqiNP_001138422.1. NM_001144950.1. [A1L4H1-1]
NP_001182196.1. NM_001195267.1. [A1L4H1-2]
UniGeneiHs.554182.

Genome annotation databases

EnsembliENST00000389623; ENSP00000374274; ENSG00000179954. [A1L4H1-1]
ENST00000587166; ENSP00000467252; ENSG00000179954.
GeneIDi284297.
KEGGihsa:284297.
UCSCiuc002qlg.4. human. [A1L4H1-1]
uc021vbw.1. human. [A1L4H1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU699476 mRNA. Translation: ACJ02751.1 .
EU699477 mRNA. Translation: ACJ02752.1 . Frameshift.
AC008735 Genomic DNA. No translation available.
BC130538 mRNA. Translation: AAI30539.1 . Different initiation.
BC130540 mRNA. Translation: AAI30541.1 . Different initiation.
CCDSi CCDS46196.1. [A1L4H1-1 ]
CCDS59424.1. [A1L4H1-2 ]
RefSeqi NP_001138422.1. NM_001144950.1. [A1L4H1-1 ]
NP_001182196.1. NM_001195267.1. [A1L4H1-2 ]
UniGenei Hs.554182.

3D structure databases

ProteinModelPortali A1L4H1.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A1L4H1.

Proteomic databases

PaxDbi A1L4H1.
PRIDEi A1L4H1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389623 ; ENSP00000374274 ; ENSG00000179954 . [A1L4H1-1 ]
ENST00000587166 ; ENSP00000467252 ; ENSG00000179954 .
GeneIDi 284297.
KEGGi hsa:284297.
UCSCi uc002qlg.4. human. [A1L4H1-1 ]
uc021vbw.1. human. [A1L4H1-2 ]

Organism-specific databases

CTDi 284297.
GeneCardsi GC19P055999.
H-InvDB HIX0015472.
HGNCi HGNC:26641. SSC5D.
HPAi HPA042008.
neXtProti NX_A1L4H1.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149171.
HOGENOMi HOG000154412.
HOVERGENi HBG108511.
OMAi PVRVMAC.
PhylomeDBi A1L4H1.
TreeFami TF329295.

Miscellaneous databases

GenomeRNAii 284297.
NextBioi 94704.
PROi A1L4H1.

Gene expression databases

ArrayExpressi A1L4H1.
Bgeei A1L4H1.
Genevestigatori A1L4H1.

Family and domain databases

Gene3Di 3.10.250.10. 5 hits.
InterProi IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view ]
Pfami PF00530. SRCR. 5 hits.
[Graphical view ]
PRINTSi PR00258. SPERACTRCPTR.
SMARTi SM00202. SR. 5 hits.
[Graphical view ]
SUPFAMi SSF56487. SSF56487. 5 hits.
PROSITEi PS00420. SRCR_1. 5 hits.
PS50287. SRCR_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and analysis of SSc5D, a new member of the scavenger receptor cysteine-rich superfamily."
    Goncalves C.M., Castro M.A., Henriques T., Oliveira M.I., Pinheiro H.C., Oliveira C., Sreenu V.B., Evans E.J., Davis S.J., Moreira A., Carmo A.M.
    Mol. Immunol. 46:2585-2596(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1475-1573 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiSRCRL_HUMAN
AccessioniPrimary (citable) accession number: A1L4H1
Secondary accession number(s): B5MDQ5
, C7S7T9, C7S7U0, K7EP70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 58 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi