A1L4H1 (SRCRL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Alternative name(s):
Soluble scavenger protein with 5 SRCR domains
Short name=SSc5D

Gene names

Name:

SSC5D

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1573 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces By similarity.
Subunit structure	Interacts with LGALS1 and laminin By similarity.
Subcellular location	Secreted By similarity. Cytoplasm By similarity.
Tissue specificity	Highly expressed in monocytes/macrophages and T-lymphocytes. Highly expressed in placenta and spleen, and also detected at lower levels in colon, and more weakly in lung, heart and kidney. Ref.1
Sequence similarities	Contains 5 SRCR domains.
Sequence caution	The sequence AAI30539.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI30541.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Immunity Innate immunity
Cellular component	Cytoplasm Secreted
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal
Molecular function	Developmental protein Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	innate immune response Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	scavenger receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A1L4H1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A1L4H1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     929-953: GSKDGYKLPWTWDTPSGRGLAEGTP → EPEAGVREVMLLVQGLPGLQRLPSP
     954-1573: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 1573	1557	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D		PRO_0000332985
Regions
	Domain	20 – 120	101	SRCR 1
	Domain	198 – 298	101	SRCR 2
	Domain	304 – 404	101	SRCR 3
	Domain	467 – 568	102	SRCR 4
	Domain	772 – 872	101	SRCR 5
	Compositional bias	616 – 729	114	Thr-rich
	Compositional bias	970 – 1488	519	Pro-rich
	Compositional bias	1089 – 1382	294	Thr-rich
	Compositional bias	1558 – 1561	4	Poly-Thr
	Compositional bias	1563 – 1566	4	Poly-Glu
Amino acid modifications
	Glycosylation	168	1	N-linked (GlcNAc...) Potential
	Glycosylation	376	1	N-linked (GlcNAc...) Potential
	Glycosylation	420	1	N-linked (GlcNAc...) Potential
	Disulfide bond	45 ↔ 109		By similarity
	Disulfide bond	58 ↔ 119		By similarity
	Disulfide bond	89 ↔ 99		By similarity
	Disulfide bond	223 ↔ 287		By similarity
	Disulfide bond	236 ↔ 297		By similarity
	Disulfide bond	267 ↔ 277		By similarity
	Disulfide bond	329 ↔ 393		By similarity
	Disulfide bond	342 ↔ 403		By similarity
	Disulfide bond	373 ↔ 383		By similarity
	Disulfide bond	492 ↔ 557		By similarity
	Disulfide bond	505 ↔ 567		By similarity
	Disulfide bond	537 ↔ 547		By similarity
	Disulfide bond	797 ↔ 861		By similarity
	Disulfide bond	810 ↔ 871		By similarity
	Disulfide bond	841 ↔ 851		By similarity
Natural variations
	Alternative sequence	929 – 953	25	GSKDG…AEGTP → EPEAGVREVMLLVQGLPGLQ RLPSP in isoform 2.		VSP_040792
	Alternative sequence	954 – 1573	620	Missing in isoform 2.		VSP_040793
Experimental info
	Sequence conflict	976	1	L → P in ACJ02751. Ref.1
	Sequence conflict	1274	1	M → I in ACJ02751. Ref.1
	Sequence conflict	1456	1	P → S in ACJ02751. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 5, 2011. Version 3. Checksum: 9151F14B58BD1A0D	FASTA	1,573	165,743
	10 20 30 40 50 60 MRVLACLLAA LVGIQAVERL RLADGPHGCA GRLEVWHGGR WGTVCDDGWD LRDAAVACRQ 70 80 90 100 110 120 LGCGGALAAP GGAFFGEGAG PVWLSELACR GNEGQLGLCH HRGWKAHICS HEEDAGVVCA 130 140 150 160 170 180 GQRVANSRDD STSPLDGAPW PGLLLELSPS TEEPLVTHAP RPAGNPQNAS RKKSPRPKQA 190 200 210 220 230 240 KSTRAPLLTT GAPRQERLRL VSGPHRCAGR LEVWHGGRWG TVCDDGWDLR DAAVACRELG 250 260 270 280 290 300 CGGALAAPGG ARFGPGAGPV WMDDVGCGGG EQALRDCPRS PWGRSNCDHS EDAGLVCTGP 310 320 330 340 350 360 APRLRLADGP HGCAGRLEVW HGGRWGSVCD DAWDLRDAAV ACRELGCGGA LAAPGGAFFG 370 380 390 400 410 420 EGSGPIILDD LRCRGNETAL RFCPARPWGQ HDCHHREDAG AVCDGMPLGY VPPTAPTDSN 430 440 450 460 470 480 NSTPREAASR PPSTMTSQAP GTAGVSPPPA SPTVLWEPGP EAGSPQLRLV AGPSKCSGRL 490 500 510 520 530 540 EVWHDQRWGT VCDDSWDMRD SAVVCRELGC GGPQQPDPAA GRFGWGAGPI WLDDVGCVGT 550 560 570 580 590 600 EASLSDCPAA PWGKHNCAHN EDVGVTCTGP PGLDSISDPF SWSWIPGLGR DRDAWLPGEL 610 620 630 640 650 660 ATKPSASVTA SVLEKTTTKA PGKMPKSTKK WVTKNAKRPT TQPPVMPTTK HSRAQSPPDL 670 680 690 700 710 720 TSQTTAALTT EASRRPTSEF TRRPTTEAPQ RWTSHTTATL TPQAPRERTT KTMAMLTTQG 730 740 750 760 770 780 PQEMTSESTI KSIPQASLEP SAEIPEGSPE SPKDPAPSPS VSTTGESGLF RVRLADGPNR 790 800 810 820 830 840 CAGRLEVWHA GRWGTVCDDN WDLRDATVAC WELGCGKVRP RVGKTHYGPG TGPIWLDDMG 850 860 870 880 890 900 CKGSEASLSD CPSGAWGKHN CDHEEDVGLT CTGYTDYDDY PPWTWDPTSR EDLAKGTTTA 910 920 930 940 950 960 GVPGHTLPWR TTRRPGSSSP AIRRLPDTGS KDGYKLPWTW DTPSGRGLAE GTPTAGKLGP 970 980 990 1000 1010 1020 TLGAGTTRSP GSPPTLRVHG DTGSPRKPWP ERRPPRPAAT RTAPPTPSPG PSASPGPPGP 1030 1040 1050 1060 1070 1080 ALTSDSSREL TPHSALTSEA TSDAPDTSPP TPDPASRTNP DLILTSPDFA LSTPDSSVVP 1090 1100 1110 1120 1130 1140 ALTPEPSPTP LPTLPKELTS DPSTPSEVTS LSPTSEQVPE SDTTPDLDTT PYSSTVSEYS 1150 1160 1170 1180 1190 1200 RSPDPSPSPH PTTTPDPTMA PDPITTLNPT VTPHFPTTPH PTTTPHPTTI THSTMIPDPT 1210 1220 1230 1240 1250 1260 TTPQPFTTIT HSTMIPDPTT TPQPFTTMQP TTTPHSTTPH PTTTPHPTTI THSTMIPDPT 1270 1280 1290 1300 1310 1320 TTPQPFTTMQ PTTMPHPTTT PHPTTTPHPT TTPHPTTTPH PTMTPDPTTT PYPTTTPDPT 1330 1340 1350 1360 1370 1380 TTPHPTTPDP SSTPVITTVS LPTSLGTELS SPTLAPTVKP SLHPQLTFTA PAPHTSTSQI 1390 1400 1410 1420 1430 1440 PTLEPSPALE SSPSRSSTAT SMDPLSTEDF KPPRSQSPNL TPPPTHTPHS ASDLTVSPDP 1450 1460 1470 1480 1490 1500 LLSPTAHPLD HPPLDPLTLG PTPGQSPGPH GPCVAPTPPV RVMACEPPAL VELVAAVRDV 1510 1520 1530 1540 1550 1560 GGQLQRLTQV VEQERQERQA LLLGLTQLVE AARGLGQLGE AVKRLAEMAW TTSMPAPTTT 1570 TPEEEERPLR GDV
	Isoform 2 [UniParc]. Checksum: 9E39E2FD892F72CF	FASTA	953	100,918
	10 20 30 40 50 60 MRVLACLLAA LVGIQAVERL RLADGPHGCA GRLEVWHGGR WGTVCDDGWD LRDAAVACRQ 70 80 90 100 110 120 LGCGGALAAP GGAFFGEGAG PVWLSELACR GNEGQLGLCH HRGWKAHICS HEEDAGVVCA 130 140 150 160 170 180 GQRVANSRDD STSPLDGAPW PGLLLELSPS TEEPLVTHAP RPAGNPQNAS RKKSPRPKQA 190 200 210 220 230 240 KSTRAPLLTT GAPRQERLRL VSGPHRCAGR LEVWHGGRWG TVCDDGWDLR DAAVACRELG 250 260 270 280 290 300 CGGALAAPGG ARFGPGAGPV WMDDVGCGGG EQALRDCPRS PWGRSNCDHS EDAGLVCTGP 310 320 330 340 350 360 APRLRLADGP HGCAGRLEVW HGGRWGSVCD DAWDLRDAAV ACRELGCGGA LAAPGGAFFG 370 380 390 400 410 420 EGSGPIILDD LRCRGNETAL RFCPARPWGQ HDCHHREDAG AVCDGMPLGY VPPTAPTDSN 430 440 450 460 470 480 NSTPREAASR PPSTMTSQAP GTAGVSPPPA SPTVLWEPGP EAGSPQLRLV AGPSKCSGRL 490 500 510 520 530 540 EVWHDQRWGT VCDDSWDMRD SAVVCRELGC GGPQQPDPAA GRFGWGAGPI WLDDVGCVGT 550 560 570 580 590 600 EASLSDCPAA PWGKHNCAHN EDVGVTCTGP PGLDSISDPF SWSWIPGLGR DRDAWLPGEL 610 620 630 640 650 660 ATKPSASVTA SVLEKTTTKA PGKMPKSTKK WVTKNAKRPT TQPPVMPTTK HSRAQSPPDL 670 680 690 700 710 720 TSQTTAALTT EASRRPTSEF TRRPTTEAPQ RWTSHTTATL TPQAPRERTT KTMAMLTTQG 730 740 750 760 770 780 PQEMTSESTI KSIPQASLEP SAEIPEGSPE SPKDPAPSPS VSTTGESGLF RVRLADGPNR 790 800 810 820 830 840 CAGRLEVWHA GRWGTVCDDN WDLRDATVAC WELGCGKVRP RVGKTHYGPG TGPIWLDDMG 850 860 870 880 890 900 CKGSEASLSD CPSGAWGKHN CDHEEDVGLT CTGYTDYDDY PPWTWDPTSR EDLAKGTTTA 910 920 930 940 950 GVPGHTLPWR TTRRPGSSSP AIRRLPDTEP EAGVREVMLL VQGLPGLQRL PSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and analysis of SSc5D, a new member of the scavenger receptor cysteine-rich superfamily." Goncalves C.M., Castro M.A., Henriques T., Oliveira M.I., Pinheiro H.C., Oliveira C., Sreenu V.B., Evans E.J., Davis S.J., Moreira A., Carmo A.M. Mol. Immunol. 46:2585-2596(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1475-1573 (ISOFORM 1). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU699476 mRNA. Translation: ACJ02751.1. EU699477 mRNA. Translation: ACJ02752.1. AC008735 Genomic DNA. No translation available. BC130538 mRNA. Translation: AAI30539.1. Different initiation. BC130540 mRNA. Translation: AAI30541.1. Different initiation.
IPI	IPI00946928. IPI00979213.
RefSeq	NP_001138422.1. NM_001144950.1. NP_001182196.1. NM_001195267.1.
UniGene	Hs.554182.
3D structure databases
ProteinModelPortal	A1L4H1.
ModBase	Search...
PTM databases
PhosphoSite	A1L4H1.
Proteomic databases
PaxDb	A1L4H1.
PRIDE	A1L4H1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000389623; ENSP00000374274; ENSG00000179954.
GeneID	284297.
KEGG	hsa:284297.
UCSC	uc002qlg.4. human.
Organism-specific databases
CTD	284297.
GeneCards	GC19P055999.
H-InvDB	HIX0015472.
HGNC	HGNC:26641. SSC5D.
HPA	HPA042008.
neXtProt	NX_A1L4H1.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG149171.
HOGENOM	HOG000154412.
HOVERGEN	HBG108511.
OMA	VMACEPP.
OrthoDB	EOG4DJJVP.
Gene expression databases
Bgee	A1L4H1.
Genevestigator	A1L4H1.
Family and domain databases
InterPro	IPR001190. Srcr_rcpt. IPR017448. Srcr_rcpt-rel. [Graphical view]
Pfam	PF00530. SRCR. 5 hits. [Graphical view]
PRINTS	PR00258. SPERACTRCPTR.
SMART	SM00202. SR. 5 hits. [Graphical view]
SUPFAM	SSF56487. Srcr_receptor. 5 hits.
PROSITE	PS00420. SRCR_1. 5 hits. PS50287. SRCR_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	284297.
NextBio	94704.

Entry information

Entry name

SRCRL_HUMAN

Accession

Primary (citable) accession number: A1L4H1
Secondary accession number(s): B5MDQ5, C7S7T9, C7S7U0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 5, 2011
Last modified:	April 3, 2013
This is version 47 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.