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A1L4H1

- SRCRL_HUMAN

UniProt

A1L4H1 - SRCRL_HUMAN

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Protein

Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Gene

SSC5D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces By similarity.By similarity

GO - Molecular functioni

  1. extracellular matrix binding Source: UniProtKB
  2. fibronectin binding Source: UniProtKB
  3. laminin binding Source: UniProtKB
  4. scavenger receptor activity Source: UniProtKB

GO - Biological processi

  1. defense response to Gram-negative bacterium Source: Ensembl
  2. defense response to Gram-positive bacterium Source: Ensembl
  3. detection of bacterial lipoprotein Source: UniProtKB
  4. innate immune response Source: UniProtKB-KW
  5. multicellular organismal development Source: UniProtKB-KW
  6. negative regulation of interleukin-8 secretion Source: UniProtKB
  7. receptor-mediated endocytosis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
Alternative name(s):
Soluble scavenger protein with 5 SRCR domains
Short name:
SSc5D
Gene namesi
Name:SSC5D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:26641. SSC5D.

Subcellular locationi

Secreted By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular matrix Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. intracellular Source: UniProtKB
  5. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 15731557Soluble scavenger receptor cysteine-rich domain-containing protein SSC5DPRO_0000332985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 109PROSITE-ProRule annotation
Disulfide bondi58 ↔ 119PROSITE-ProRule annotation
Disulfide bondi89 ↔ 99PROSITE-ProRule annotation
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi223 ↔ 287PROSITE-ProRule annotation
Disulfide bondi236 ↔ 297PROSITE-ProRule annotation
Disulfide bondi267 ↔ 277PROSITE-ProRule annotation
Disulfide bondi329 ↔ 393PROSITE-ProRule annotation
Disulfide bondi342 ↔ 403PROSITE-ProRule annotation
Disulfide bondi373 ↔ 383PROSITE-ProRule annotation
Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi492 ↔ 557PROSITE-ProRule annotation
Disulfide bondi505 ↔ 567PROSITE-ProRule annotation
Disulfide bondi537 ↔ 547PROSITE-ProRule annotation
Disulfide bondi797 ↔ 861PROSITE-ProRule annotation
Disulfide bondi810 ↔ 871PROSITE-ProRule annotation
Disulfide bondi841 ↔ 851PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA1L4H1.
PRIDEiA1L4H1.

PTM databases

PhosphoSiteiA1L4H1.

Expressioni

Tissue specificityi

Highly expressed in monocytes/macrophages and T-lymphocytes. Highly expressed in placenta and spleen, and also detected at lower levels in colon, and more weakly in lung, heart and kidney.1 Publication

Gene expression databases

BgeeiA1L4H1.
ExpressionAtlasiA1L4H1. baseline and differential.
GenevestigatoriA1L4H1.

Organism-specific databases

HPAiHPA042008.

Interactioni

Subunit structurei

Interacts with LGALS1 and laminin.By similarity

Structurei

3D structure databases

ProteinModelPortaliA1L4H1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 120101SRCR 1PROSITE-ProRule annotationAdd
BLAST
Domaini198 – 298101SRCR 2PROSITE-ProRule annotationAdd
BLAST
Domaini304 – 404101SRCR 3PROSITE-ProRule annotationAdd
BLAST
Domaini467 – 568102SRCR 4PROSITE-ProRule annotationAdd
BLAST
Domaini772 – 872101SRCR 5PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi616 – 729114Thr-richAdd
BLAST
Compositional biasi970 – 1488519Pro-richAdd
BLAST
Compositional biasi1089 – 1382294Thr-richAdd
BLAST
Compositional biasi1558 – 15614Poly-Thr
Compositional biasi1563 – 15664Poly-Glu

Sequence similaritiesi

Contains 5 SRCR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG149171.
GeneTreeiENSGT00760000118953.
HOGENOMiHOG000154412.
HOVERGENiHBG108511.
InParanoidiA1L4H1.
OMAiPVRVMAC.
PhylomeDBiA1L4H1.
TreeFamiTF329295.

Family and domain databases

Gene3Di3.10.250.10. 5 hits.
InterProiIPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF00530. SRCR. 5 hits.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 5 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 5 hits.
PROSITEiPS00420. SRCR_1. 5 hits.
PS50287. SRCR_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A1L4H1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVLACLLAA LVGIQAVERL RLADGPHGCA GRLEVWHGGR WGTVCDDGWD
60 70 80 90 100
LRDAAVACRQ LGCGGALAAP GGAFFGEGAG PVWLSELACR GNEGQLGLCH
110 120 130 140 150
HRGWKAHICS HEEDAGVVCA GQRVANSRDD STSPLDGAPW PGLLLELSPS
160 170 180 190 200
TEEPLVTHAP RPAGNPQNAS RKKSPRPKQA KSTRAPLLTT GAPRQERLRL
210 220 230 240 250
VSGPHRCAGR LEVWHGGRWG TVCDDGWDLR DAAVACRELG CGGALAAPGG
260 270 280 290 300
ARFGPGAGPV WMDDVGCGGG EQALRDCPRS PWGRSNCDHS EDAGLVCTGP
310 320 330 340 350
APRLRLADGP HGCAGRLEVW HGGRWGSVCD DAWDLRDAAV ACRELGCGGA
360 370 380 390 400
LAAPGGAFFG EGSGPIILDD LRCRGNETAL RFCPARPWGQ HDCHHREDAG
410 420 430 440 450
AVCDGMPLGY VPPTAPTDSN NSTPREAASR PPSTMTSQAP GTAGVSPPPA
460 470 480 490 500
SPTVLWEPGP EAGSPQLRLV AGPSKCSGRL EVWHDQRWGT VCDDSWDMRD
510 520 530 540 550
SAVVCRELGC GGPQQPDPAA GRFGWGAGPI WLDDVGCVGT EASLSDCPAA
560 570 580 590 600
PWGKHNCAHN EDVGVTCTGP PGLDSISDPF SWSWIPGLGR DRDAWLPGEL
610 620 630 640 650
ATKPSASVTA SVLEKTTTKA PGKMPKSTKK WVTKNAKRPT TQPPVMPTTK
660 670 680 690 700
HSRAQSPPDL TSQTTAALTT EASRRPTSEF TRRPTTEAPQ RWTSHTTATL
710 720 730 740 750
TPQAPRERTT KTMAMLTTQG PQEMTSESTI KSIPQASLEP SAEIPEGSPE
760 770 780 790 800
SPKDPAPSPS VSTTGESGLF RVRLADGPNR CAGRLEVWHA GRWGTVCDDN
810 820 830 840 850
WDLRDATVAC WELGCGKVRP RVGKTHYGPG TGPIWLDDMG CKGSEASLSD
860 870 880 890 900
CPSGAWGKHN CDHEEDVGLT CTGYTDYDDY PPWTWDPTSR EDLAKGTTTA
910 920 930 940 950
GVPGHTLPWR TTRRPGSSSP AIRRLPDTGS KDGYKLPWTW DTPSGRGLAE
960 970 980 990 1000
GTPTAGKLGP TLGAGTTRSP GSPPTLRVHG DTGSPRKPWP ERRPPRPAAT
1010 1020 1030 1040 1050
RTAPPTPSPG PSASPGPPGP ALTSDSSREL TPHSALTSEA TSDAPDTSPP
1060 1070 1080 1090 1100
TPDPASRTNP DLILTSPDFA LSTPDSSVVP ALTPEPSPTP LPTLPKELTS
1110 1120 1130 1140 1150
DPSTPSEVTS LSPTSEQVPE SDTTPDLDTT PYSSTVSEYS RSPDPSPSPH
1160 1170 1180 1190 1200
PTTTPDPTMA PDPITTLNPT VTPHFPTTPH PTTTPHPTTI THSTMIPDPT
1210 1220 1230 1240 1250
TTPQPFTTIT HSTMIPDPTT TPQPFTTMQP TTTPHSTTPH PTTTPHPTTI
1260 1270 1280 1290 1300
THSTMIPDPT TTPQPFTTMQ PTTMPHPTTT PHPTTTPHPT TTPHPTTTPH
1310 1320 1330 1340 1350
PTMTPDPTTT PYPTTTPDPT TTPHPTTPDP SSTPVITTVS LPTSLGTELS
1360 1370 1380 1390 1400
SPTLAPTVKP SLHPQLTFTA PAPHTSTSQI PTLEPSPALE SSPSRSSTAT
1410 1420 1430 1440 1450
SMDPLSTEDF KPPRSQSPNL TPPPTHTPHS ASDLTVSPDP LLSPTAHPLD
1460 1470 1480 1490 1500
HPPLDPLTLG PTPGQSPGPH GPCVAPTPPV RVMACEPPAL VELVAAVRDV
1510 1520 1530 1540 1550
GGQLQRLTQV VEQERQERQA LLLGLTQLVE AARGLGQLGE AVKRLAEMAW
1560 1570
TTSMPAPTTT TPEEEERPLR GDV
Length:1,573
Mass (Da):165,743
Last modified:April 5, 2011 - v3
Checksum:i9151F14B58BD1A0D
GO
Isoform 2 (identifier: A1L4H1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     929-953: GSKDGYKLPWTWDTPSGRGLAEGTP → EPEAGAPRGDAPRSRTARVAAPP
     954-1573: Missing.

Show »
Length:951
Mass (Da):100,561
Checksum:iDE1008BB0541B78C
GO

Sequence cautioni

The sequence ACJ02752.1 differs from that shown. Reason: Frameshift at position 934.
The sequence AAI30539.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAI30541.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti976 – 9761L → P in ACJ02751. (PubMed:19535143)Curated
Sequence conflicti1274 – 12741M → I in ACJ02751. (PubMed:19535143)Curated
Sequence conflicti1456 – 14561P → S in ACJ02751. (PubMed:19535143)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei929 – 95325GSKDG…AEGTP → EPEAGAPRGDAPRSRTARVA APP in isoform 2. 1 PublicationVSP_040792Add
BLAST
Alternative sequencei954 – 1573620Missing in isoform 2. 1 PublicationVSP_040793Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU699476 mRNA. Translation: ACJ02751.1.
EU699477 mRNA. Translation: ACJ02752.1. Frameshift.
AC008735 Genomic DNA. No translation available.
BC130538 mRNA. Translation: AAI30539.1. Different initiation.
BC130540 mRNA. Translation: AAI30541.1. Different initiation.
CCDSiCCDS46196.1. [A1L4H1-1]
CCDS59424.1. [A1L4H1-2]
RefSeqiNP_001138422.1. NM_001144950.1. [A1L4H1-1]
NP_001182196.1. NM_001195267.1. [A1L4H1-2]
UniGeneiHs.554182.

Genome annotation databases

EnsembliENST00000389623; ENSP00000374274; ENSG00000179954. [A1L4H1-1]
ENST00000587166; ENSP00000467252; ENSG00000179954. [A1L4H1-2]
GeneIDi284297.
KEGGihsa:284297.
UCSCiuc002qlg.4. human. [A1L4H1-1]
uc021vbw.1. human. [A1L4H1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU699476 mRNA. Translation: ACJ02751.1 .
EU699477 mRNA. Translation: ACJ02752.1 . Frameshift.
AC008735 Genomic DNA. No translation available.
BC130538 mRNA. Translation: AAI30539.1 . Different initiation.
BC130540 mRNA. Translation: AAI30541.1 . Different initiation.
CCDSi CCDS46196.1. [A1L4H1-1 ]
CCDS59424.1. [A1L4H1-2 ]
RefSeqi NP_001138422.1. NM_001144950.1. [A1L4H1-1 ]
NP_001182196.1. NM_001195267.1. [A1L4H1-2 ]
UniGenei Hs.554182.

3D structure databases

ProteinModelPortali A1L4H1.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A1L4H1.

Proteomic databases

PaxDbi A1L4H1.
PRIDEi A1L4H1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389623 ; ENSP00000374274 ; ENSG00000179954 . [A1L4H1-1 ]
ENST00000587166 ; ENSP00000467252 ; ENSG00000179954 . [A1L4H1-2 ]
GeneIDi 284297.
KEGGi hsa:284297.
UCSCi uc002qlg.4. human. [A1L4H1-1 ]
uc021vbw.1. human. [A1L4H1-2 ]

Organism-specific databases

CTDi 284297.
GeneCardsi GC19P055999.
H-InvDB HIX0015472.
HGNCi HGNC:26641. SSC5D.
HPAi HPA042008.
neXtProti NX_A1L4H1.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149171.
GeneTreei ENSGT00760000118953.
HOGENOMi HOG000154412.
HOVERGENi HBG108511.
InParanoidi A1L4H1.
OMAi PVRVMAC.
PhylomeDBi A1L4H1.
TreeFami TF329295.

Miscellaneous databases

GenomeRNAii 284297.
NextBioi 94704.
PROi A1L4H1.

Gene expression databases

Bgeei A1L4H1.
ExpressionAtlasi A1L4H1. baseline and differential.
Genevestigatori A1L4H1.

Family and domain databases

Gene3Di 3.10.250.10. 5 hits.
InterProi IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view ]
Pfami PF00530. SRCR. 5 hits.
[Graphical view ]
PRINTSi PR00258. SPERACTRCPTR.
SMARTi SM00202. SR. 5 hits.
[Graphical view ]
SUPFAMi SSF56487. SSF56487. 5 hits.
PROSITEi PS00420. SRCR_1. 5 hits.
PS50287. SRCR_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and analysis of SSc5D, a new member of the scavenger receptor cysteine-rich superfamily."
    Goncalves C.M., Castro M.A., Henriques T., Oliveira M.I., Pinheiro H.C., Oliveira C., Sreenu V.B., Evans E.J., Davis S.J., Moreira A., Carmo A.M.
    Mol. Immunol. 46:2585-2596(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1475-1573 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiSRCRL_HUMAN
AccessioniPrimary (citable) accession number: A1L4H1
Secondary accession number(s): B5MDQ5
, C7S7T9, C7S7U0, K7EP70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 60 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3