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Protein

NUT family member 2F

Gene

NUTM2F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
NUT family member 2F
Gene namesi
Name:NUTM2F
Synonyms:FAM22F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23450. NUTM2F.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981634.

Polymorphism and mutation databases

BioMutaiNUTM2F.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 756756NUT family member 2FPRO_0000337995Add
BLAST

Proteomic databases

PaxDbiA1L443.
PRIDEiA1L443.

PTM databases

iPTMnetiA1L443.
PhosphoSiteiA1L443.

Expressioni

Gene expression databases

BgeeiENSG00000130950.
CleanExiHS_FAM22F.
ExpressionAtlasiA1L443. baseline and differential.
GenevisibleiA1L443. HS.

Organism-specific databases

HPAiCAB012471.

Interactioni

Protein-protein interaction databases

BioGridi120131. 3 interactions.
STRINGi9606.ENSP00000253262.

Structurei

3D structure databases

ProteinModelPortaliA1L443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 1627Poly-Pro
Compositional biasi302 – 39291Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the NUT family.Curated

Phylogenomic databases

eggNOGiENOG410J94Q. Eukaryota.
ENOG4111C0H. LUCA.
GeneTreeiENSGT00410000025793.
HOGENOMiHOG000112470.
HOVERGENiHBG107898.
InParanoidiA1L443.
OMAiEPEGQWE.
OrthoDBiEOG091G034P.
PhylomeDBiA1L443.
TreeFamiTF337728.

Family and domain databases

InterProiIPR024310. NUT.
IPR024309. NUT_N.
[Graphical view]
PANTHERiPTHR22879. PTHR22879. 2 hits.
PfamiPF12881. NUT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNGAYPVL GPGVTVNPGT SLSVFTALPF ATPAPGPAHR PPLVTAVVPP
60 70 80 90 100
AGPLVLSAFP STPLVAGQDG RGPSGAGASN VFVQMRTEVG PVKPPQAQTL
110 120 130 140 150
ILTQAPLVWQ APGTLCGGVM CPPPLLLAAA PGVPVTSAQV VGGTQACEGG
160 170 180 190 200
WSHGLPLPPP PPAAQVAPIV SPGNARPWPQ GAHGEGSLAP SQAKARPDDS
210 220 230 240 250
CKPKSVYENF RLWQHYKPLA RRHLPQSPDT EALSCFLIPV LRSLARRKPT
260 270 280 290 300
MTLEEGLWQA MREWQHTSNF DRMIFYEMAE KFLEFEAEEE MQIQKSQWMK
310 320 330 340 350
GPQSLPPPAP PRLEPRGPPA PEVVKQPVYL PSKDGPKAPT ACLPPPRPQR
360 370 380 390 400
PAETKAHLPP PRPQRPAETN AHLPPPRPQR PAETKVPEEI PPEVVQEYVD
410 420 430 440 450
IMEELLGSHP GDTGEPEGQR EKGKVEQPQE EDGITSDPGL LSYIDKLCSQ
460 470 480 490 500
EDFVTKVEAV IHPRFLEELL SPDPQMDFLA LSQELEQEEG LTLAQLVEKR
510 520 530 540 550
LLSLKEKGCG RAAPRHGTAR LDSSPSEFAA GQEAAREVPD PQQRVSVETS
560 570 580 590 600
PPQTAAQDPQ GQGRVRTGMA RSEDPAVLLG CQDSPRLKAV RPTSPPQDHR
610 620 630 640 650
PTCPGLGTKD ALGLPGESPV KESHGLAKGS SEETELPGMV YVVGSHHRLR
660 670 680 690 700
PWRLSQSPVP SSGLLSPGGR GPQGALQSPS AQKRGLSPSP SPASKSKKRP
710 720 730 740 750
LFGSPSPAEK TPHPGPGLRV SGEQSLAWGL GGPSQSQKRK GDPLASRRKK

KRHCSQ
Length:756
Mass (Da):80,770
Last modified:June 10, 2008 - v2
Checksum:i51642CA607C736E0
GO

Sequence cautioni

The sequence CAI13277 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI13278 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261L → F in AAI30391 (PubMed:15489334).Curated
Sequence conflicti691 – 6911Missing in AAI30391 (PubMed:15489334).Curated
Sequence conflicti691 – 6911Missing in CAB61394 (PubMed:17974005).Curated
Sequence conflicti731 – 7311G → R in CAB61394 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti137 – 1371S → C.
Corresponds to variant rs202099818 [ dbSNP | Ensembl ].
VAR_068009
Natural varianti176 – 1761R → G.2 Publications
Corresponds to variant rs2479282 [ dbSNP | Ensembl ].
VAR_068010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691447 Genomic DNA. Translation: CAI13277.1. Sequence problems.
AL691447 Genomic DNA. Translation: CAI13278.1. Sequence problems.
BC130390 mRNA. Translation: AAI30391.1.
AL133071 mRNA. Translation: CAB61394.1.
CCDSiCCDS47994.1.
PIRiT42671.
RefSeqiNP_060031.1. NM_017561.1.
UniGeneiHs.648183.

Genome annotation databases

EnsembliENST00000253262; ENSP00000253262; ENSG00000130950.
GeneIDi54754.
KEGGihsa:54754.
UCSCiuc004aup.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691447 Genomic DNA. Translation: CAI13277.1. Sequence problems.
AL691447 Genomic DNA. Translation: CAI13278.1. Sequence problems.
BC130390 mRNA. Translation: AAI30391.1.
AL133071 mRNA. Translation: CAB61394.1.
CCDSiCCDS47994.1.
PIRiT42671.
RefSeqiNP_060031.1. NM_017561.1.
UniGeneiHs.648183.

3D structure databases

ProteinModelPortaliA1L443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120131. 3 interactions.
STRINGi9606.ENSP00000253262.

PTM databases

iPTMnetiA1L443.
PhosphoSiteiA1L443.

Polymorphism and mutation databases

BioMutaiNUTM2F.

Proteomic databases

PaxDbiA1L443.
PRIDEiA1L443.

Protocols and materials databases

DNASUi54754.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253262; ENSP00000253262; ENSG00000130950.
GeneIDi54754.
KEGGihsa:54754.
UCSCiuc004aup.1. human.

Organism-specific databases

CTDi54754.
GeneCardsiNUTM2F.
H-InvDBHIX0008188.
HGNCiHGNC:23450. NUTM2F.
HPAiCAB012471.
neXtProtiNX_A1L443.
PharmGKBiPA134981634.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J94Q. Eukaryota.
ENOG4111C0H. LUCA.
GeneTreeiENSGT00410000025793.
HOGENOMiHOG000112470.
HOVERGENiHBG107898.
InParanoidiA1L443.
OMAiEPEGQWE.
OrthoDBiEOG091G034P.
PhylomeDBiA1L443.
TreeFamiTF337728.

Miscellaneous databases

GenomeRNAii54754.
PROiA1L443.

Gene expression databases

BgeeiENSG00000130950.
CleanExiHS_FAM22F.
ExpressionAtlasiA1L443. baseline and differential.
GenevisibleiA1L443. HS.

Family and domain databases

InterProiIPR024310. NUT.
IPR024309. NUT_N.
[Graphical view]
PANTHERiPTHR22879. PTHR22879. 2 hits.
PfamiPF12881. NUT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTM2F_HUMAN
AccessioniPrimary (citable) accession number: A1L443
Secondary accession number(s): B6ZDF0
, Q5SR58, Q5SR59, Q9UFB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: September 7, 2016
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.