ID   GG12C_HUMAN             Reviewed;         117 AA.
AC   A1L429; A6NHF1; B7ZL74;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   24-JAN-2024, entry version 111.
DE   RecName: Full=G antigen 12B/C/D/E;
DE            Short=GAGE-12B;
DE            Short=GAGE-12C;
DE            Short=GAGE-12D;
DE            Short=GAGE-12E;
GN   Name=GAGE12B;
GN   and
GN   Name=GAGE12C;
GN   and
GN   Name=GAGE12D;
GN   and
GN   Name=GAGE12E;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   GAGE FAMILY.
RX   PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA   Gjerstorff M.F., Ditzel H.J.;
RT   "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT   newly identified members.";
RL   Tissue Antigens 71:187-192(2008).
CC   -!- INTERACTION:
CC       A1L429; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-10172187, EBI-10172181;
CC       A1L429; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-10172187, EBI-745707;
CC   -!- MISCELLANEOUS: This gene belongs to a multigene family expressed in a
CC       large variety of tumors whereas in normal tissues, expression is
CC       restricted to germ cells. These genes organized in clustered repeats,
CC       have a high degree of predicted sequence identity, but differ by
CC       scattered single nucleotide substitution. Their sequences contain
CC       either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized
CC       by cytotoxic T-cells.
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC       sequences, but the high identity of the GAGE members made impossible to
CC       separate products of paralogous genes from polymorph products.
CC       PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC       identified genes and their products. GAGE12B is present as fragment in
CC       GRCh37 reference genome assembly due to an unsequenced gap between two
CC       clusters in the GAGE locus. {ECO:0000305}.
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DR   EMBL; AC142497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC130374; AAI30375.1; -; mRNA.
DR   EMBL; BC143615; AAI43616.1; -; mRNA.
DR   EMBL; BC143619; AAI43620.1; -; mRNA.
DR   CCDS; CCDS43943.1; -.
DR   CCDS; CCDS43945.1; -.
DR   CCDS; CCDS48113.1; -.
DR   RefSeq; NP_001091878.1; NM_001098408.1.
DR   RefSeq; NP_001091888.1; NM_001098418.1.
DR   RefSeq; NP_001120671.1; NM_001127199.1.
DR   RefSeq; NP_001120817.1; NM_001127345.1.
DR   AlphaFoldDB; A1L429; -.
DR   BioGRID; 609823; 1.
DR   BioGRID; 609829; 3.
DR   BioGRID; 609832; 1.
DR   BioGRID; 935801; 1.
DR   IntAct; A1L429; 2.
DR   STRING; 9606.ENSP00000371117; -.
DR   iPTMnet; A1L429; -.
DR   PhosphoSitePlus; A1L429; -.
DR   BioMuta; GAGE12B; -.
DR   jPOST; A1L429; -.
DR   MassIVE; A1L429; -.
DR   MaxQB; A1L429; -.
DR   PaxDb; 9606-ENSP00000371117; -.
DR   PeptideAtlas; A1L429; -.
DR   Pumba; A1L429; -.
DR   Antibodypedia; 66732; 31 antibodies from 8 providers.
DR   Antibodypedia; 75828; 7 antibodies from 4 providers.
DR   Antibodypedia; 77265; 3 antibodies from 2 providers.
DR   DNASU; 729428; -.
DR   Ensembl; ENST00000381698.5; ENSP00000371117.3; ENSG00000216649.5.
DR   Ensembl; ENST00000405679.4; ENSP00000384214.3; ENSG00000227488.3.
DR   Ensembl; ENST00000420398.3; ENSP00000397103.2; ENSG00000237671.4.
DR   GeneID; 100132399; -.
DR   GeneID; 729422; -.
DR   GeneID; 729428; -.
DR   GeneID; 729431; -.
DR   KEGG; hsa:100132399; -.
DR   KEGG; hsa:729422; -.
DR   KEGG; hsa:729428; -.
DR   KEGG; hsa:729431; -.
DR   MANE-Select; ENST00000381698.5; ENSP00000371117.3; NM_001098418.3; NP_001091888.1.
DR   MANE-Select; ENST00000405679.4; ENSP00000384214.3; NM_001127199.3; NP_001120671.1.
DR   MANE-Select; ENST00000420398.3; ENSP00000397103.2; NM_001098408.3; NP_001091878.1.
DR   UCSC; uc004doc.5; human.
DR   AGR; HGNC:26779; -.
DR   AGR; HGNC:28402; -.
DR   AGR; HGNC:31904; -.
DR   AGR; HGNC:31905; -.
DR   CTD; 100132399; -.
DR   CTD; 729422; -.
DR   CTD; 729428; -.
DR   CTD; 729431; -.
DR   DisGeNET; 100132399; -.
DR   DisGeNET; 729422; -.
DR   DisGeNET; 729428; -.
DR   DisGeNET; 729431; -.
DR   GeneCards; GAGE12B; -.
DR   GeneCards; GAGE12C; -.
DR   GeneCards; GAGE12D; -.
DR   GeneCards; GAGE12E; -.
DR   HGNC; HGNC:26779; GAGE12B.
DR   HGNC; HGNC:28402; GAGE12C.
DR   HGNC; HGNC:31904; GAGE12D.
DR   HGNC; HGNC:31905; GAGE12E.
DR   HPA; ENSG00000216649; Tissue enriched (testis).
DR   HPA; ENSG00000227488; Tissue enriched (testis).
DR   HPA; ENSG00000237671; Tissue enriched (testis).
DR   MIM; 300727; gene.
DR   MIM; 300728; gene.
DR   MIM; 300729; gene.
DR   neXtProt; NX_A1L429; -.
DR   PharmGKB; PA145148775; -.
DR   VEuPathDB; HostDB:ENSG00000216649; -.
DR   VEuPathDB; HostDB:ENSG00000227488; -.
DR   VEuPathDB; HostDB:ENSG00000237671; -.
DR   eggNOG; ENOG502SZ68; Eukaryota.
DR   GeneTree; ENSGT00940000153097; -.
DR   HOGENOM; CLU_150116_0_0_1; -.
DR   InParanoid; A1L429; -.
DR   OrthoDB; 4660048at2759; -.
DR   PhylomeDB; A1L429; -.
DR   TreeFam; TF340669; -.
DR   PathwayCommons; A1L429; -.
DR   SignaLink; A1L429; -.
DR   BioGRID-ORCS; 100132399; 7 hits in 47 CRISPR screens.
DR   BioGRID-ORCS; 729422; 7 hits in 155 CRISPR screens.
DR   BioGRID-ORCS; 729428; 13 hits in 74 CRISPR screens.
DR   BioGRID-ORCS; 729431; 4 hits in 33 CRISPR screens.
DR   Pharos; A1L429; Tdark.
DR   PRO; PR:A1L429; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; A1L429; Protein.
DR   Bgee; ENSG00000216649; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 68 other cell types or tissues.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047:SF30; G ANTIGEN 1-RELATED; 1.
DR   PANTHER; PTHR14047; P ANTIGEN FAMILY MEMBER 5-RELATED; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
DR   Genevisible; A1L429; HS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..117
FT                   /note="G antigen 12B/C/D/E"
FT                   /id="PRO_0000311977"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..117
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   117 AA;  12925 MW;  C35ED8CEB9D1DD07 CRC64;
     MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQC QDPAAAQEGE
     DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC
//