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A1L429

- GG12C_HUMAN

UniProt

A1L429 - GG12C_HUMAN

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Protein
G antigen 12B/C/D/E
Gene
GAGE12B
GAGE12C
GAGE12D
GAGE12E
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
G antigen 12B/C/D/E
Short name:
GAGE-12B
Short name:
GAGE-12C
Short name:
GAGE-12D
Short name:
GAGE-12E
Gene namesi
Name:GAGE12B
AND
Name:GAGE12C
AND
Name:GAGE12D
AND
Name:GAGE12E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X
HGNCiHGNC:26779. GAGE12B.
HGNC:28402. GAGE12C.
HGNC:31904. GAGE12D.
HGNC:31905. GAGE12E.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148775.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117G antigen 12B/C/D/E
PRO_0000311977Add
BLAST

Proteomic databases

PRIDEiA1L429.

PTM databases

PhosphoSiteiA1L429.

Expressioni

Gene expression databases

BgeeiA1L429.
GenevestigatoriA1L429.

Organism-specific databases

HPAiHPA043232.

Structurei

3D structure databases

ProteinModelPortaliA1L429.

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.

Phylogenomic databases

HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiA1L429.
OrthoDBiEOG7XM316.
PhylomeDBiA1L429.
TreeFamiTF340669.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L429-1 [UniParc]FASTAAdd to Basket

« Hide

MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQC    50
QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP 100
NPEEVKTPEE GEKQSQC 117
Length:117
Mass (Da):12,925
Last modified:February 6, 2007 - v1
Checksum:iC35ED8CEB9D1DD07
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC142497 Genomic DNA. No translation available.
BC130374 mRNA. Translation: AAI30375.1.
BC143615 mRNA. Translation: AAI43616.1.
BC143619 mRNA. Translation: AAI43620.1.
CCDSiCCDS43943.1.
CCDS43945.1.
CCDS48113.1.
RefSeqiNP_001091878.1. NM_001098408.1.
NP_001091888.1. NM_001098418.1.
NP_001120671.1. NM_001127199.1.
NP_001120817.1. NM_001127345.1.
UniGeneiHs.632812.
Hs.645554.

Genome annotation databases

EnsembliENST00000381698; ENSP00000371117; ENSG00000216649.
ENST00000405679; ENSP00000384214; ENSG00000227488.
ENST00000420398; ENSP00000397103; ENSG00000237671.
ENST00000593608; ENSP00000470925; ENSG00000268016.
ENST00000600217; ENSP00000469479; ENSG00000270290.
ENST00000600913; ENSP00000472334; ENSG00000271641.
GeneIDi100132399.
729422.
729428.
729431.
KEGGihsa:100132399.
hsa:729422.
hsa:729428.
hsa:729431.
UCSCiuc004doc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC142497 Genomic DNA. No translation available.
BC130374 mRNA. Translation: AAI30375.1 .
BC143615 mRNA. Translation: AAI43616.1 .
BC143619 mRNA. Translation: AAI43620.1 .
CCDSi CCDS43943.1.
CCDS43945.1.
CCDS48113.1.
RefSeqi NP_001091878.1. NM_001098408.1.
NP_001091888.1. NM_001098418.1.
NP_001120671.1. NM_001127199.1.
NP_001120817.1. NM_001127345.1.
UniGenei Hs.632812.
Hs.645554.

3D structure databases

ProteinModelPortali A1L429.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A1L429.

Proteomic databases

PRIDEi A1L429.

Protocols and materials databases

DNASUi 729428.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381698 ; ENSP00000371117 ; ENSG00000216649 .
ENST00000405679 ; ENSP00000384214 ; ENSG00000227488 .
ENST00000420398 ; ENSP00000397103 ; ENSG00000237671 .
ENST00000593608 ; ENSP00000470925 ; ENSG00000268016 .
ENST00000600217 ; ENSP00000469479 ; ENSG00000270290 .
ENST00000600913 ; ENSP00000472334 ; ENSG00000271641 .
GeneIDi 100132399.
729422.
729428.
729431.
KEGGi hsa:100132399.
hsa:729422.
hsa:729428.
hsa:729431.
UCSCi uc004doc.4. human.

Organism-specific databases

CTDi 100132399.
729422.
729428.
729431.
GeneCardsi GC0XP049295.
GC0XP049300.
GC0XP049306.
GC0XP049321.
HGNCi HGNC:26779. GAGE12B.
HGNC:28402. GAGE12C.
HGNC:31904. GAGE12D.
HGNC:31905. GAGE12E.
HPAi HPA043232.
MIMi 300727. gene.
300728. gene.
300729. gene.
neXtProti NX_A1L429.
PharmGKBi PA145148775.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000237345.
HOVERGENi HBG056227.
InParanoidi A1L429.
OrthoDBi EOG7XM316.
PhylomeDBi A1L429.
TreeFami TF340669.

Miscellaneous databases

NextBioi 130204.
PROi A1L429.
SOURCEi Search...

Gene expression databases

Bgeei A1L429.
Genevestigatori A1L429.

Family and domain databases

InterProi IPR008625. GAGE.
[Graphical view ]
Pfami PF05831. GAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Placenta.
  3. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
    Gjerstorff M.F., Ditzel H.J.
    Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GAGE FAMILY.

Entry informationi

Entry nameiGG12C_HUMAN
AccessioniPrimary (citable) accession number: A1L429
Secondary accession number(s): A6NHF1, B7ZL74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. 1 Publication presented a new GAGE gene nomenclature based on the identified genes and their products. GAGE12B is present as fragment in GRCh37 reference genome assembly due to an unsequenced gap between two clusters in the GAGE locus.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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