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Protein

G antigen 12B/C/D/E

Gene

GAGE12B

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 12B/C/D/E
Short name:
GAGE-12B
Short name:
GAGE-12C
Short name:
GAGE-12D
Short name:
GAGE-12E
Gene namesi
Name:GAGE12B
AND
Name:GAGE12C
AND
Name:GAGE12D
AND
Name:GAGE12E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:26779. GAGE12B.
HGNC:28402. GAGE12C.
HGNC:31904. GAGE12D.
HGNC:31905. GAGE12E.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148775.

Polymorphism and mutation databases

BioMutaiGAGE12B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117G antigen 12B/C/D/EPRO_0000311977Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA1L429.

PTM databases

PhosphoSiteiA1L429.

Expressioni

Gene expression databases

BgeeiA1L429.
GenevestigatoriA1L429.

Organism-specific databases

HPAiHPA043232.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FLJ13057Q53SE73EBI-10172187,EBI-10172181
GMCL1P1Q8NEA93EBI-10172187,EBI-745707

Protein-protein interaction databases

BioGridi609829. 2 interactions.
IntActiA1L429. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliA1L429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119480.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiA1L429.
OrthoDBiEOG7XM316.
PhylomeDBiA1L429.
TreeFamiTF340669.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQC
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,925
Last modified:February 6, 2007 - v1
Checksum:iC35ED8CEB9D1DD07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC142497 Genomic DNA. No translation available.
BC130374 mRNA. Translation: AAI30375.1.
BC143615 mRNA. Translation: AAI43616.1.
BC143619 mRNA. Translation: AAI43620.1.
CCDSiCCDS43943.1.
CCDS43945.1.
CCDS48113.1.
RefSeqiNP_001091878.1. NM_001098408.1.
NP_001091888.1. NM_001098418.1.
NP_001120671.1. NM_001127199.1.
NP_001120817.1. NM_001127345.1.
UniGeneiHs.632812.
Hs.645554.

Genome annotation databases

EnsembliENST00000381698; ENSP00000371117; ENSG00000216649.
ENST00000405679; ENSP00000384214; ENSG00000227488.
ENST00000420398; ENSP00000397103; ENSG00000237671.
GeneIDi100132399.
729422.
729428.
729431.
KEGGihsa:100132399.
hsa:729422.
hsa:729428.
hsa:729431.
UCSCiuc004doc.4. human.

Polymorphism and mutation databases

BioMutaiGAGE12B.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC142497 Genomic DNA. No translation available.
BC130374 mRNA. Translation: AAI30375.1.
BC143615 mRNA. Translation: AAI43616.1.
BC143619 mRNA. Translation: AAI43620.1.
CCDSiCCDS43943.1.
CCDS43945.1.
CCDS48113.1.
RefSeqiNP_001091878.1. NM_001098408.1.
NP_001091888.1. NM_001098418.1.
NP_001120671.1. NM_001127199.1.
NP_001120817.1. NM_001127345.1.
UniGeneiHs.632812.
Hs.645554.

3D structure databases

ProteinModelPortaliA1L429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi609829. 2 interactions.
IntActiA1L429. 2 interactions.

PTM databases

PhosphoSiteiA1L429.

Polymorphism and mutation databases

BioMutaiGAGE12B.

Proteomic databases

PRIDEiA1L429.

Protocols and materials databases

DNASUi729428.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381698; ENSP00000371117; ENSG00000216649.
ENST00000405679; ENSP00000384214; ENSG00000227488.
ENST00000420398; ENSP00000397103; ENSG00000237671.
GeneIDi100132399.
729422.
729428.
729431.
KEGGihsa:100132399.
hsa:729422.
hsa:729428.
hsa:729431.
UCSCiuc004doc.4. human.

Organism-specific databases

CTDi100132399.
729422.
729428.
729431.
GeneCardsiGC0XP049295.
GC0XP049300.
GC0XP049306.
GC0XP049321.
HGNCiHGNC:26779. GAGE12B.
HGNC:28402. GAGE12C.
HGNC:31904. GAGE12D.
HGNC:31905. GAGE12E.
HPAiHPA043232.
MIMi300727. gene.
300728. gene.
300729. gene.
neXtProtiNX_A1L429.
PharmGKBiPA145148775.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119480.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiA1L429.
OrthoDBiEOG7XM316.
PhylomeDBiA1L429.
TreeFamiTF340669.

Miscellaneous databases

NextBioi130204.
PROiA1L429.
SOURCEiSearch...

Gene expression databases

BgeeiA1L429.
GenevestigatoriA1L429.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Placenta.
  3. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
    Gjerstorff M.F., Ditzel H.J.
    Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GAGE FAMILY.

Entry informationi

Entry nameiGG12C_HUMAN
AccessioniPrimary (citable) accession number: A1L429
Secondary accession number(s): A6NHF1, B7ZL74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 6, 2007
Last modified: April 29, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products. GAGE12B is present as fragment in GRCh37 reference genome assembly due to an unsequenced gap between two clusters in the GAGE locus.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.