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A1L429

- GG12C_HUMAN

UniProt

A1L429 - GG12C_HUMAN

Protein

G antigen 12B/C/D/E

Gene

GAGE12B

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    G antigen 12B/C/D/E
    Short name:
    GAGE-12B
    Short name:
    GAGE-12C
    Short name:
    GAGE-12D
    Short name:
    GAGE-12E
    Gene namesi
    Name:GAGE12B
    AND
    Name:GAGE12C
    AND
    Name:GAGE12D
    AND
    Name:GAGE12E
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:26779. GAGE12B.
    HGNC:28402. GAGE12C.
    HGNC:31904. GAGE12D.
    HGNC:31905. GAGE12E.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148775.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 117117G antigen 12B/C/D/EPRO_0000311977Add
    BLAST

    Proteomic databases

    PRIDEiA1L429.

    PTM databases

    PhosphoSiteiA1L429.

    Expressioni

    Gene expression databases

    BgeeiA1L429.
    GenevestigatoriA1L429.

    Organism-specific databases

    HPAiHPA043232.

    Structurei

    3D structure databases

    ProteinModelPortaliA1L429.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GAGE family.Curated

    Phylogenomic databases

    HOGENOMiHOG000237345.
    HOVERGENiHBG056227.
    InParanoidiA1L429.
    OrthoDBiEOG7XM316.
    PhylomeDBiA1L429.
    TreeFamiTF340669.

    Family and domain databases

    InterProiIPR008625. GAGE.
    [Graphical view]
    PfamiPF05831. GAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1L429-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQC    50
    QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP 100
    NPEEVKTPEE GEKQSQC 117
    Length:117
    Mass (Da):12,925
    Last modified:February 6, 2007 - v1
    Checksum:iC35ED8CEB9D1DD07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC142497 Genomic DNA. No translation available.
    BC130374 mRNA. Translation: AAI30375.1.
    BC143615 mRNA. Translation: AAI43616.1.
    BC143619 mRNA. Translation: AAI43620.1.
    CCDSiCCDS43943.1.
    CCDS43945.1.
    CCDS48113.1.
    RefSeqiNP_001091878.1. NM_001098408.1.
    NP_001091888.1. NM_001098418.1.
    NP_001120671.1. NM_001127199.1.
    NP_001120817.1. NM_001127345.1.
    UniGeneiHs.632812.
    Hs.645554.

    Genome annotation databases

    EnsembliENST00000381698; ENSP00000371117; ENSG00000216649.
    ENST00000405679; ENSP00000384214; ENSG00000227488.
    ENST00000420398; ENSP00000397103; ENSG00000237671.
    GeneIDi100132399.
    729422.
    729428.
    729431.
    KEGGihsa:100132399.
    hsa:729422.
    hsa:729428.
    hsa:729431.
    UCSCiuc004doc.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC142497 Genomic DNA. No translation available.
    BC130374 mRNA. Translation: AAI30375.1 .
    BC143615 mRNA. Translation: AAI43616.1 .
    BC143619 mRNA. Translation: AAI43620.1 .
    CCDSi CCDS43943.1.
    CCDS43945.1.
    CCDS48113.1.
    RefSeqi NP_001091878.1. NM_001098408.1.
    NP_001091888.1. NM_001098418.1.
    NP_001120671.1. NM_001127199.1.
    NP_001120817.1. NM_001127345.1.
    UniGenei Hs.632812.
    Hs.645554.

    3D structure databases

    ProteinModelPortali A1L429.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A1L429.

    Proteomic databases

    PRIDEi A1L429.

    Protocols and materials databases

    DNASUi 729428.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381698 ; ENSP00000371117 ; ENSG00000216649 .
    ENST00000405679 ; ENSP00000384214 ; ENSG00000227488 .
    ENST00000420398 ; ENSP00000397103 ; ENSG00000237671 .
    GeneIDi 100132399.
    729422.
    729428.
    729431.
    KEGGi hsa:100132399.
    hsa:729422.
    hsa:729428.
    hsa:729431.
    UCSCi uc004doc.4. human.

    Organism-specific databases

    CTDi 100132399.
    729422.
    729428.
    729431.
    GeneCardsi GC0XP049295.
    GC0XP049300.
    GC0XP049306.
    GC0XP049321.
    HGNCi HGNC:26779. GAGE12B.
    HGNC:28402. GAGE12C.
    HGNC:31904. GAGE12D.
    HGNC:31905. GAGE12E.
    HPAi HPA043232.
    MIMi 300727. gene.
    300728. gene.
    300729. gene.
    neXtProti NX_A1L429.
    PharmGKBi PA145148775.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000237345.
    HOVERGENi HBG056227.
    InParanoidi A1L429.
    OrthoDBi EOG7XM316.
    PhylomeDBi A1L429.
    TreeFami TF340669.

    Miscellaneous databases

    NextBioi 130204.
    PROi A1L429.
    SOURCEi Search...

    Gene expression databases

    Bgeei A1L429.
    Genevestigatori A1L429.

    Family and domain databases

    InterProi IPR008625. GAGE.
    [Graphical view ]
    Pfami PF05831. GAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Placenta.
    3. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
      Gjerstorff M.F., Ditzel H.J.
      Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GAGE FAMILY.

    Entry informationi

    Entry nameiGG12C_HUMAN
    AccessioniPrimary (citable) accession number: A1L429
    Secondary accession number(s): A6NHF1, B7ZL74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

    Caution

    The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products. GAGE12B is present as fragment in GRCh37 reference genome assembly due to an unsequenced gap between two clusters in the GAGE locus.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3