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Protein

G antigen 12B/C/D/E

Gene

GAGE12B

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 12B/C/D/E
Short name:
GAGE-12B
Short name:
GAGE-12C
Short name:
GAGE-12D
Short name:
GAGE-12E
Gene namesi
Name:GAGE12B
AND
Name:GAGE12C
AND
Name:GAGE12D
AND
Name:GAGE12E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000216649.3.
HostDB:ENSG00000227488.2.
HostDB:ENSG00000237671.3.
HGNCiHGNC:26779. GAGE12B.
HGNC:28402. GAGE12C.
HGNC:31904. GAGE12D.
HGNC:31905. GAGE12E.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148775.

Polymorphism and mutation databases

BioMutaiGAGE12B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119771 – 117G antigen 12B/C/D/EAdd BLAST117

Proteomic databases

MaxQBiA1L429.
PaxDbiA1L429.
PRIDEiA1L429.

PTM databases

iPTMnetiA1L429.
PhosphoSitePlusiA1L429.

Expressioni

Gene expression databases

BgeeiENSG00000216649.
GenevisibleiA1L429. HS.

Organism-specific databases

HPAiHPA043232.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi609829. 2 interactors.
IntActiA1L429. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliA1L429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC. Eukaryota.
ENOG4110Q8D. LUCA.
GeneTreeiENSGT00900000141202.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiA1L429.
OrthoDBiEOG09370LAN.
PhylomeDBiA1L429.
TreeFamiTF340669.

Family and domain databases

InterProiView protein in InterPro
IPR031320. GAGE.
IPR008625. GAGE_fam.
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiView protein in Pfam
PF05831. GAGE. 1 hit.
SMARTiView protein in SMART
SM01379. GAGE. 1 hit.

Sequencei

Sequence statusi: Complete.

A1L429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQC
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,925
Last modified:February 6, 2007 - v1
Checksum:iC35ED8CEB9D1DD07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC142497 Genomic DNA. No translation available.
BC130374 mRNA. Translation: AAI30375.1.
BC143615 mRNA. Translation: AAI43616.1.
BC143619 mRNA. Translation: AAI43620.1.
CCDSiCCDS43943.1.
CCDS43945.1.
CCDS48113.1.
RefSeqiNP_001091878.1. NM_001098408.1.
NP_001091888.1. NM_001098418.1.
NP_001120671.1. NM_001127199.1.
NP_001120817.1. NM_001127345.1.
UniGeneiHs.632812.
Hs.645554.

Genome annotation databases

EnsembliENST00000381698; ENSP00000371117; ENSG00000216649.
ENST00000405679; ENSP00000384214; ENSG00000227488.
ENST00000420398; ENSP00000397103; ENSG00000237671.
GeneIDi100132399.
729422.
729428.
729431.
KEGGihsa:100132399.
hsa:729422.
hsa:729428.
hsa:729431.
UCSCiuc004doc.5. human.

Similar proteinsi

Entry informationi

Entry nameiGG12C_HUMAN
AccessioniPrimary (citable) accession number: A1L429
Secondary accession number(s): A6NHF1, B7ZL74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products. GAGE12B is present as fragment in GRCh37 reference genome assembly due to an unsequenced gap between two clusters in the GAGE locus.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families