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Protein

G antigen 12B/C/D/E

Gene

GAGE12B

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products. GAGE12B is present as fragment in GRCh37 reference genome assembly due to an unsequenced gap between two clusters in the GAGE locus.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 12B/C/D/E
Short name:
GAGE-12B
Short name:
GAGE-12C
Short name:
GAGE-12D
Short name:
GAGE-12E
Gene namesi
Name:GAGE12B
AND
Name:GAGE12C
AND
Name:GAGE12D
AND
Name:GAGE12E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000216649.3
HostDB:ENSG00000227488.2
HostDB:ENSG00000237671.3
HGNCiHGNC:26779 GAGE12B
HGNC:28402 GAGE12C
HGNC:31904 GAGE12D
HGNC:31905 GAGE12E
MIMi300727 gene
300728 gene
300729 gene
neXtProtiNX_A1L429

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148775

Polymorphism and mutation databases

BioMutaiGAGE12B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119771 – 117G antigen 12B/C/D/EAdd BLAST117

Proteomic databases

MaxQBiA1L429
PaxDbiA1L429
PRIDEiA1L429

PTM databases

iPTMnetiA1L429
PhosphoSitePlusiA1L429

Expressioni

Gene expression databases

BgeeiENSG00000216649
GenevisibleiA1L429 HS

Organism-specific databases

HPAiHPA043232

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi609829, 2 interactors
IntActiA1L429, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliA1L429
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
GeneTreeiENSGT00900000141202
HOGENOMiHOG000237345
HOVERGENiHBG056227
InParanoidiA1L429
OrthoDBiEOG09370LAN
PhylomeDBiA1L429
TreeFamiTF340669

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

Sequencei

Sequence statusi: Complete.

A1L429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQC
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,925
Last modified:February 6, 2007 - v1
Checksum:iC35ED8CEB9D1DD07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC142497 Genomic DNA No translation available.
BC130374 mRNA Translation: AAI30375.1
BC143615 mRNA Translation: AAI43616.1
BC143619 mRNA Translation: AAI43620.1
CCDSiCCDS43943.1
CCDS43945.1
CCDS48113.1
RefSeqiNP_001091878.1, NM_001098408.1
NP_001091888.1, NM_001098418.1
NP_001120671.1, NM_001127199.1
NP_001120817.1, NM_001127345.1
UniGeneiHs.632812
Hs.645554

Genome annotation databases

EnsembliENST00000381698; ENSP00000371117; ENSG00000216649
ENST00000405679; ENSP00000384214; ENSG00000227488
ENST00000420398; ENSP00000397103; ENSG00000237671
GeneIDi100132399
729422
729428
729431
KEGGihsa:100132399
hsa:729422
hsa:729428
hsa:729431
UCSCiuc004doc.5 human

Similar proteinsi

Entry informationi

Entry nameiGG12C_HUMAN
AccessioniPrimary (citable) accession number: A1L429
Secondary accession number(s): A6NHF1, B7ZL74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health