Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative metallothionein MT1DP

Gene

MT1DP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster BBy similarity1
Metal bindingi7Divalent metal cation; cluster BBy similarity1
Metal bindingi13Divalent metal cation; cluster BBy similarity1
Metal bindingi15Divalent metal cation; cluster BBy similarity1
Metal bindingi19Divalent metal cation; cluster BBy similarity1
Metal bindingi21Divalent metal cation; cluster BBy similarity1
Metal bindingi26Divalent metal cation; cluster BBy similarity1
Metal bindingi29Divalent metal cation; cluster BBy similarity1
Metal bindingi33Divalent metal cation; cluster ABy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi36Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi41Divalent metal cation; cluster ABy similarity1
Metal bindingi44Divalent metal cation; cluster ABy similarity1
Metal bindingi48Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Enzyme and pathway databases

BioCyciZFISH:G66-33687-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative metallothionein MT1DP
Gene namesi
Name:MT1DP
Synonyms:MTM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:7396. MT1DP.

Pathology & Biotechi

Organism-specific databases

DisGeNETi326343.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003434261 – 49Putative metallothionein MT1DPAdd BLAST49

Proteomic databases

PRIDEiA1L3X4.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-5P603703EBI-10172129,EBI-10172150
KRTAP10-9P604113EBI-10172129,EBI-10172052
MEOX2A4D1275EBI-10172129,EBI-10172134

Protein-protein interaction databases

IntActiA1L3X4. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliA1L3X4.
SMRiA1L3X4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 49AlphaAdd BLAST20

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.

Sequencei

Sequence statusi: Complete.

A1L3X4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MDLSCSCATG GSCTCASSCK CKEYKCTSCK KNCCSCCPMG CAKCAQGCT
Length:49
Mass (Da):4,983
Last modified:February 6, 2007 - v1
Checksum:iD3FCBF95F9FBEFA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45A → S in AAO32959 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348999 mRNA. Translation: AAO32959.2.
UniGeneiHs.679600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348999 mRNA. Translation: AAO32959.2.
UniGeneiHs.679600.

3D structure databases

ProteinModelPortaliA1L3X4.
SMRiA1L3X4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA1L3X4. 3 interactors.

Proteomic databases

PRIDEiA1L3X4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi326343.
GeneCardsiMT1DP.
HGNCiHGNC:7396. MT1DP.
neXtProtiNX_A1L3X4.
GenAtlasiSearch...

Enzyme and pathway databases

BioCyciZFISH:G66-33687-MONOMER.

Miscellaneous databases

ChiTaRSiMT1DP. human.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMT1DP_HUMAN
AccessioniPrimary (citable) accession number: A1L3X4
Secondary accession number(s): Q86YX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: February 6, 2007
Last modified: November 30, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.