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A1L3P4

- A1L3P4_MOUSE

UniProt

A1L3P4 - A1L3P4_MOUSE

Protein

Sodium/hydrogen exchanger

Gene

Slc9a6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sodium:proton antiporter activity Source: InterPro

    GO - Biological processi

    1. axon extension Source: MGI
    2. brain-derived neurotrophic factor receptor signaling pathway Source: MGI
    3. dendrite extension Source: MGI
    4. dendritic spine development Source: MGI
    5. neuron projection morphogenesis Source: MGI
    6. proton transport Source: MGI
    7. regulation of neurotrophin TRK receptor signaling pathway Source: MGI
    8. regulation of pH Source: InterPro
    9. synapse organization Source: MGI

    Keywords - Biological processi

    AntiportUniRule annotationSAAS annotation, Ion transport, Sodium transportUniRule annotation, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/hydrogen exchangerUniRule annotation
    Gene namesi
    Name:Slc9a6Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:2443511. Slc9a6.

    Subcellular locationi

    GO - Cellular componenti

    1. axonal spine Source: MGI
    2. axon terminus Source: MGI
    3. cytoplasmic vesicle Source: MGI
    4. dendrite Source: MGI
    5. early endosome Source: MGI
    6. early endosome membrane Source: Ensembl
    7. endoplasmic reticulum membrane Source: Ensembl
    8. endosome Source: MGI
    9. integral component of membrane Source: UniProtKB-KW
    10. late endosome Source: MGI
    11. mitochondrion Source: MGI
    12. plasma membrane Source: MGI
    13. recycling endosome Source: MGI
    14. recycling endosome membrane Source: Ensembl
    15. synapse Source: MGI

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriA1L3P4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    eggNOGiCOG0025.
    GeneTreeiENSGT00560000076802.
    HOGENOMiHOG000172307.
    HOVERGENiHBG055575.
    InParanoidiA1L3P4.
    KOiK12041.
    OMAiDQEHLGV.
    OrthoDBiEOG7NW69D.
    TreeFamiTF318755.

    Family and domain databases

    InterProiIPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR002090. Na/H_exchanger_6.
    IPR004709. NaH_exchanger.
    [Graphical view]
    PANTHERiPTHR10110. PTHR10110. 1 hit.
    PfamiPF00999. Na_H_Exchanger. 1 hit.
    [Graphical view]
    PRINTSiPR01084. NAHEXCHNGR.
    PR01088. NAHEXCHNGR6.
    TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1L3P4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGARRGWRL APVRRGVCGP RARPLMRPLW LLFAVSFFGW TGALDGSGGT    50
    TRAMDEEIVS EKQAEESHRQ DSANLLIFIL LLTLTILTIW LFKHRRARFL 100
    HETGLAMIYG LLVGLVLRYG IHVPSDVNNV TLSCEVQSSP TTLLVNVSGK 150
    FYEYTLKGEI SSHELNNVQD NEMLRKVTFD PEVFFNILLP PIIFYAGYSL 200
    KRRHFFRNLG SILAYAFLGT AISCFVIGSI MYGCVTLMKV TGQLAGDFYF 250
    TDCLLFGAIV SATDPVTVLA IFHELQVDVE LYALLFGESV LNDAVAIVLS 300
    SSIVAYQPAG DNSHTFDVTA MFKSIGIFLG IFSGSFAMGA ATGVVTALVT 350
    KFTKLREFQL LETGLFFLMS WSTFLLAEAW GFTGVVAVLF CGITQAHYTY 400
    NNLSTESQHR TKQLFELLNF LAENFIFSYM GLTLFTFQNH VFNPTFVVGA 450
    FIAIFLGRAA NIYPLSLLLN LGRRSKIGSN FQHMMMFAGL RGAMAFALAI 500
    RDTATYARQM MFSTTLLIVF FTVWVFGGGT TAMLSCLHIR VGVDSDQEHL 550
    GVPDNERRTT KAESAWLFRM WYNFDHNYLK PLLTHSGPPL TTTLPACCGP 600
    IARCLTSPQA YENQEQLKDD DSDLILNDGD ISLTYGDSTV NTESATASAP 650
    RRFMGNSSED ALDRELTFGD HELVIRGTRL VLPMDDSEPA LNSLDDTRHS 700
    PA 702
    Length:702
    Mass (Da):77,953
    Last modified:February 6, 2007 - v1
    Checksum:i243F0126533B5547
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC048362 Genomic DNA. No translation available.
    AL672085 Genomic DNA. No translation available.
    BC130221 mRNA. Translation: AAI30222.1.
    RefSeqiNP_766368.2. NM_172780.3.
    UniGeneiMm.17815.

    Genome annotation databases

    EnsembliENSMUST00000077741; ENSMUSP00000076922; ENSMUSG00000060681.
    GeneIDi236794.
    KEGGimmu:236794.
    UCSCiuc009tgk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC048362 Genomic DNA. No translation available.
    AL672085 Genomic DNA. No translation available.
    BC130221 mRNA. Translation: AAI30222.1 .
    RefSeqi NP_766368.2. NM_172780.3.
    UniGenei Mm.17815.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077741 ; ENSMUSP00000076922 ; ENSMUSG00000060681 .
    GeneIDi 236794.
    KEGGi mmu:236794.
    UCSCi uc009tgk.2. mouse.

    Organism-specific databases

    CTDi 10479.
    MGIi MGI:2443511. Slc9a6.

    Phylogenomic databases

    eggNOGi COG0025.
    GeneTreei ENSGT00560000076802.
    HOGENOMi HOG000172307.
    HOVERGENi HBG055575.
    InParanoidi A1L3P4.
    KOi K12041.
    OMAi DQEHLGV.
    OrthoDBi EOG7NW69D.
    TreeFami TF318755.

    Miscellaneous databases

    NextBioi 383086.
    PROi A1L3P4.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori A1L3P4.

    Family and domain databases

    InterProi IPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR002090. Na/H_exchanger_6.
    IPR004709. NaH_exchanger.
    [Graphical view ]
    PANTHERi PTHR10110. PTHR10110. 1 hit.
    Pfami PF00999. Na_H_Exchanger. 1 hit.
    [Graphical view ]
    PRINTSi PR01084. NAHEXCHNGR.
    PR01088. NAHEXCHNGR6.
    TIGRFAMsi TIGR00840. b_cpa1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescued clonesImported.
    2. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA1L3P4_MOUSE
    AccessioniPrimary (citable) accession number: A1L3P4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3