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A1L3P4

- A1L3P4_MOUSE

UniProt

A1L3P4 - A1L3P4_MOUSE

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Protein

Sodium/hydrogen exchanger

Gene

Slc9a6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. sodium:proton antiporter activity Source: InterPro

GO - Biological processi

  1. axon extension Source: MGI
  2. brain-derived neurotrophic factor receptor signaling pathway Source: MGI
  3. dendrite extension Source: MGI
  4. dendritic spine development Source: MGI
  5. neuron projection morphogenesis Source: MGI
  6. proton transport Source: MGI
  7. regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  8. regulation of pH Source: InterPro
  9. synapse organization Source: MGI
Complete GO annotation...

Keywords - Biological processi

AntiportUniRule annotationSAAS annotation, Ion transport, Sodium transportUniRule annotation, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchangerUniRule annotation
Gene namesi
Name:Slc9a6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2443511. Slc9a6.

Subcellular locationi

GO - Cellular componenti

  1. axonal spine Source: MGI
  2. axon terminus Source: MGI
  3. cytoplasmic vesicle Source: MGI
  4. dendrite Source: MGI
  5. early endosome Source: MGI
  6. early endosome membrane Source: Ensembl
  7. endoplasmic reticulum membrane Source: Ensembl
  8. endosome Source: MGI
  9. integral component of membrane Source: UniProtKB-KW
  10. late endosome Source: MGI
  11. mitochondrion Source: MGI
  12. plasma membrane Source: MGI
  13. recycling endosome Source: MGI
  14. recycling endosome membrane Source: Ensembl
  15. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriA1L3P4.

Family & Domainsi

Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

eggNOGiCOG0025.
GeneTreeiENSGT00760000119074.
HOGENOMiHOG000172307.
HOVERGENiHBG055575.
KOiK12041.
OMAiDQEHLGV.
OrthoDBiEOG7NW69D.
TreeFamiTF318755.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

Sequencei

Sequence statusi: Complete.

A1L3P4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGARRGWRL APVRRGVCGP RARPLMRPLW LLFAVSFFGW TGALDGSGGT
60 70 80 90 100
TRAMDEEIVS EKQAEESHRQ DSANLLIFIL LLTLTILTIW LFKHRRARFL
110 120 130 140 150
HETGLAMIYG LLVGLVLRYG IHVPSDVNNV TLSCEVQSSP TTLLVNVSGK
160 170 180 190 200
FYEYTLKGEI SSHELNNVQD NEMLRKVTFD PEVFFNILLP PIIFYAGYSL
210 220 230 240 250
KRRHFFRNLG SILAYAFLGT AISCFVIGSI MYGCVTLMKV TGQLAGDFYF
260 270 280 290 300
TDCLLFGAIV SATDPVTVLA IFHELQVDVE LYALLFGESV LNDAVAIVLS
310 320 330 340 350
SSIVAYQPAG DNSHTFDVTA MFKSIGIFLG IFSGSFAMGA ATGVVTALVT
360 370 380 390 400
KFTKLREFQL LETGLFFLMS WSTFLLAEAW GFTGVVAVLF CGITQAHYTY
410 420 430 440 450
NNLSTESQHR TKQLFELLNF LAENFIFSYM GLTLFTFQNH VFNPTFVVGA
460 470 480 490 500
FIAIFLGRAA NIYPLSLLLN LGRRSKIGSN FQHMMMFAGL RGAMAFALAI
510 520 530 540 550
RDTATYARQM MFSTTLLIVF FTVWVFGGGT TAMLSCLHIR VGVDSDQEHL
560 570 580 590 600
GVPDNERRTT KAESAWLFRM WYNFDHNYLK PLLTHSGPPL TTTLPACCGP
610 620 630 640 650
IARCLTSPQA YENQEQLKDD DSDLILNDGD ISLTYGDSTV NTESATASAP
660 670 680 690 700
RRFMGNSSED ALDRELTFGD HELVIRGTRL VLPMDDSEPA LNSLDDTRHS

PA
Length:702
Mass (Da):77,953
Last modified:February 6, 2007 - v1
Checksum:i243F0126533B5547
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC048362 Genomic DNA. No translation available.
AL672085 Genomic DNA. No translation available.
BC130221 mRNA. Translation: AAI30222.1.
RefSeqiNP_766368.2. NM_172780.3.
UniGeneiMm.17815.

Genome annotation databases

EnsembliENSMUST00000077741; ENSMUSP00000076922; ENSMUSG00000060681.
GeneIDi236794.
KEGGimmu:236794.
UCSCiuc009tgk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC048362 Genomic DNA. No translation available.
AL672085 Genomic DNA. No translation available.
BC130221 mRNA. Translation: AAI30222.1 .
RefSeqi NP_766368.2. NM_172780.3.
UniGenei Mm.17815.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077741 ; ENSMUSP00000076922 ; ENSMUSG00000060681 .
GeneIDi 236794.
KEGGi mmu:236794.
UCSCi uc009tgk.2. mouse.

Organism-specific databases

CTDi 10479.
MGIi MGI:2443511. Slc9a6.

Phylogenomic databases

eggNOGi COG0025.
GeneTreei ENSGT00760000119074.
HOGENOMi HOG000172307.
HOVERGENi HBG055575.
KOi K12041.
OMAi DQEHLGV.
OrthoDBi EOG7NW69D.
TreeFami TF318755.

Miscellaneous databases

NextBioi 383086.
PROi A1L3P4.
SOURCEi Search...

Gene expression databases

Genevestigatori A1L3P4.

Family and domain databases

InterProi IPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR004709. NaH_exchanger.
[Graphical view ]
PANTHERi PTHR10110. PTHR10110. 1 hit.
Pfami PF00999. Na_H_Exchanger. 1 hit.
[Graphical view ]
PRINTSi PR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.
TIGRFAMsi TIGR00840. b_cpa1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.
  2. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA1L3P4_MOUSE
AccessioniPrimary (citable) accession number: A1L3P4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3