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A1L3P4

- A1L3P4_MOUSE

UniProt

A1L3P4 - A1L3P4_MOUSE

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Protein
Sodium/hydrogen exchanger
Gene
Slc9a6
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. sodium:proton antiporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. axon extension Source: MGI
  2. brain-derived neurotrophic factor receptor signaling pathway Source: MGI
  3. dendrite extension Source: MGI
  4. dendritic spine development Source: MGI
  5. neuron projection morphogenesis Source: MGI
  6. proton transport Source: MGI
  7. regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  8. regulation of pH Source: InterPro
  9. synapse organization Source: MGI
Complete GO annotation...

Keywords - Biological processi

AntiportUniRule annotationSAAS annotations, Ion transport, Sodium transportUniRule annotation, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchangerUniRule annotation
Gene namesi
Name:Slc9a6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2443511. Slc9a6.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: MGI
  2. axonal spine Source: MGI
  3. cytoplasmic vesicle Source: MGI
  4. dendrite Source: MGI
  5. early endosome Source: MGI
  6. early endosome membrane Source: Ensembl
  7. endoplasmic reticulum membrane Source: Ensembl
  8. endosome Source: MGI
  9. integral component of membrane Source: UniProtKB-KW
  10. late endosome Source: MGI
  11. mitochondrion Source: MGI
  12. plasma membrane Source: MGI
  13. recycling endosome Source: MGI
  14. recycling endosome membrane Source: Ensembl
  15. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriA1L3P4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

eggNOGiCOG0025.
GeneTreeiENSGT00560000076802.
HOGENOMiHOG000172307.
HOVERGENiHBG055575.
InParanoidiA1L3P4.
KOiK12041.
OMAiDQEHLGV.
OrthoDBiEOG7NW69D.
TreeFamiTF318755.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

Sequencei

Sequence statusi: Complete.

A1L3P4-1 [UniParc]FASTAAdd to Basket

« Hide

MAGARRGWRL APVRRGVCGP RARPLMRPLW LLFAVSFFGW TGALDGSGGT    50
TRAMDEEIVS EKQAEESHRQ DSANLLIFIL LLTLTILTIW LFKHRRARFL 100
HETGLAMIYG LLVGLVLRYG IHVPSDVNNV TLSCEVQSSP TTLLVNVSGK 150
FYEYTLKGEI SSHELNNVQD NEMLRKVTFD PEVFFNILLP PIIFYAGYSL 200
KRRHFFRNLG SILAYAFLGT AISCFVIGSI MYGCVTLMKV TGQLAGDFYF 250
TDCLLFGAIV SATDPVTVLA IFHELQVDVE LYALLFGESV LNDAVAIVLS 300
SSIVAYQPAG DNSHTFDVTA MFKSIGIFLG IFSGSFAMGA ATGVVTALVT 350
KFTKLREFQL LETGLFFLMS WSTFLLAEAW GFTGVVAVLF CGITQAHYTY 400
NNLSTESQHR TKQLFELLNF LAENFIFSYM GLTLFTFQNH VFNPTFVVGA 450
FIAIFLGRAA NIYPLSLLLN LGRRSKIGSN FQHMMMFAGL RGAMAFALAI 500
RDTATYARQM MFSTTLLIVF FTVWVFGGGT TAMLSCLHIR VGVDSDQEHL 550
GVPDNERRTT KAESAWLFRM WYNFDHNYLK PLLTHSGPPL TTTLPACCGP 600
IARCLTSPQA YENQEQLKDD DSDLILNDGD ISLTYGDSTV NTESATASAP 650
RRFMGNSSED ALDRELTFGD HELVIRGTRL VLPMDDSEPA LNSLDDTRHS 700
PA 702
Length:702
Mass (Da):77,953
Last modified:February 6, 2007 - v1
Checksum:i243F0126533B5547
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC048362 Genomic DNA. No translation available.
AL672085 Genomic DNA. No translation available.
BC130221 mRNA. Translation: AAI30222.1.
RefSeqiNP_766368.2. NM_172780.3.
UniGeneiMm.17815.

Genome annotation databases

EnsembliENSMUST00000077741; ENSMUSP00000076922; ENSMUSG00000060681.
GeneIDi236794.
KEGGimmu:236794.
UCSCiuc009tgk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC048362 Genomic DNA. No translation available.
AL672085 Genomic DNA. No translation available.
BC130221 mRNA. Translation: AAI30222.1 .
RefSeqi NP_766368.2. NM_172780.3.
UniGenei Mm.17815.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077741 ; ENSMUSP00000076922 ; ENSMUSG00000060681 .
GeneIDi 236794.
KEGGi mmu:236794.
UCSCi uc009tgk.2. mouse.

Organism-specific databases

CTDi 10479.
MGIi MGI:2443511. Slc9a6.

Phylogenomic databases

eggNOGi COG0025.
GeneTreei ENSGT00560000076802.
HOGENOMi HOG000172307.
HOVERGENi HBG055575.
InParanoidi A1L3P4.
KOi K12041.
OMAi DQEHLGV.
OrthoDBi EOG7NW69D.
TreeFami TF318755.

Miscellaneous databases

NextBioi 383086.
PROi A1L3P4.
SOURCEi Search...

Gene expression databases

Genevestigatori A1L3P4.

Family and domain databases

InterProi IPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR004709. NaH_exchanger.
[Graphical view ]
PANTHERi PTHR10110. PTHR10110. 1 hit.
Pfami PF00999. Na_H_Exchanger. 1 hit.
[Graphical view ]
PRINTSi PR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.
TIGRFAMsi TIGR00840. b_cpa1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.
  2. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA1L3P4_MOUSE
AccessioniPrimary (citable) accession number: A1L3P4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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