A1L3P4 (A1L3P4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Sodium/hydrogen exchanger RuleBase RU003722

Gene names

Name:

Slc9a6 MGI 2443511 EMBL AAI30222.1 Ensembl ENSMUSP00000076922

Organism

Mus musculus (Mouse) [Reference proteome] EMBL AAI30222.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	702 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification] RuleBase RU003722

Ontologies

Keywords
Biological process	Antiport RuleBase RU003722 Ion transport Sodium transport SAAS SAAS018422 RuleBase RU003722 Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS018422
Ligand	Sodium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of pH Inferred from electronic annotation. Source: InterPro
Cellular_component	early endosome membrane Inferred from electronic annotation. Source: Compara endoplasmic reticulum membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from direct assay PubMed 14651853. Source: MGI plasma membrane Inferred from electronic annotation. Source: Compara recycling endosome membrane Inferred from electronic annotation. Source: Compara
Molecular_function	sodium:hydrogen antiporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1L3P4 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 243F0126533B5547	FASTA	702	77,953
	10 20 30 40 50 60 MAGARRGWRL APVRRGVCGP RARPLMRPLW LLFAVSFFGW TGALDGSGGT TRAMDEEIVS 70 80 90 100 110 120 EKQAEESHRQ DSANLLIFIL LLTLTILTIW LFKHRRARFL HETGLAMIYG LLVGLVLRYG 130 140 150 160 170 180 IHVPSDVNNV TLSCEVQSSP TTLLVNVSGK FYEYTLKGEI SSHELNNVQD NEMLRKVTFD 190 200 210 220 230 240 PEVFFNILLP PIIFYAGYSL KRRHFFRNLG SILAYAFLGT AISCFVIGSI MYGCVTLMKV 250 260 270 280 290 300 TGQLAGDFYF TDCLLFGAIV SATDPVTVLA IFHELQVDVE LYALLFGESV LNDAVAIVLS 310 320 330 340 350 360 SSIVAYQPAG DNSHTFDVTA MFKSIGIFLG IFSGSFAMGA ATGVVTALVT KFTKLREFQL 370 380 390 400 410 420 LETGLFFLMS WSTFLLAEAW GFTGVVAVLF CGITQAHYTY NNLSTESQHR TKQLFELLNF 430 440 450 460 470 480 LAENFIFSYM GLTLFTFQNH VFNPTFVVGA FIAIFLGRAA NIYPLSLLLN LGRRSKIGSN 490 500 510 520 530 540 FQHMMMFAGL RGAMAFALAI RDTATYARQM MFSTTLLIVF FTVWVFGGGT TAMLSCLHIR 550 560 570 580 590 600 VGVDSDQEHL GVPDNERRTT KAESAWLFRM WYNFDHNYLK PLLTHSGPPL TTTLPACCGP 610 620 630 640 650 660 IARCLTSPQA YENQEQLKDD DSDLILNDGD ISLTYGDSTV NTESATASAP RRFMGNSSED 670 680 690 700 ALDRELTFGD HELVIRGTRL VLPMDDSEPA LNSLDDTRHS PA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PCR rescued clones EMBL AAI30222.1.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000076922.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000076922.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC048362 Genomic DNA. No translation available. AL672085 Genomic DNA. No translation available. BC130221 mRNA. Translation: AAI30222.1.
IPI	IPI00225023.
RefSeq	NP_766368.2. NM_172780.3.
UniGene	Mm.17815.
3D structure databases
SMR	A1L3P4. Positions 251-279.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000077741; ENSMUSP00000076922; ENSMUSG00000060681.
GeneID	236794.
KEGG	mmu:236794.
UCSC	uc009tgk.2. mouse.
Organism-specific databases
CTD	10479.
MGI	MGI:2443511. Slc9a6.
Phylogenomic databases
eggNOG	COG0025.
GeneTree	ENSGT00560000076802.
HOGENOM	HOG000172307.
HOVERGEN	HBG055575.
InParanoid	A1L3P4.
KO	K12041.
OrthoDB	EOG418BMW.
Gene expression databases
Genevestigator	A1L3P4.
Family and domain databases
InterPro	IPR006153. Cation/H_exchanger. IPR018422. Cation/H_exchanger_CPA1. IPR002090. Na/H_exchanger_6. IPR004709. NaH_exchanger. [Graphical view]
PANTHER	PTHR10110. PTHR10110. 1 hit.
Pfam	PF00999. Na_H_Exchanger. 1 hit. [Graphical view]
PRINTS	PR01084. NAHEXCHNGR. PR01088. NAHEXCHNGR6.
TIGRFAMs	TIGR00840. b_cpa1. 1 hit.
ProtoNet	Search...
Other
NextBio	383086.
SOURCE	Search...

Entry information

Entry name

A1L3P4_MOUSE

Accession

Primary (citable) accession number: A1L3P4

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)