A1L3L9 (2ABB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Alternative name(s):
PP2A subunit B isoform B55-beta
PP2A subunit B isoform PR55-beta
PP2A subunit B isoform R2-beta
PP2A subunit B isoform beta

Gene names

Name:	ppp2r2b
Synonyms:	ppp2r2b-a, ppp2r2c

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment By similarity. Negatively control the initiation of oocyte maturation. Ref.1
Subunit structure	PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits By similarity.
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton By similarity. Membrane By similarity.
Sequence similarities	Belongs to the phosphatase 2A regulatory subunit B family. Contains 7 WD repeats.
Caution	It is uncertain whether Met-1 or Met-19 is the initiator.
Sequence caution	The sequence AAI30185.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Membrane
Domain	Repeat WD repeat
Gene Ontology (GO)
Biological_process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell protein phosphatase type 2A complex Inferred from electronic annotation. Source: InterPro
Molecular_function	protein phosphatase type 2A regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform		PRO_0000383349
Regions
	Repeat	47 – 86	40	WD 1
	Repeat	112 – 153	42	WD 2
	Repeat	196 – 234	39	WD 3
	Repeat	245 – 285	41	WD 4
	Repeat	304 – 342	39	WD 5
	Repeat	359 – 400	42	WD 6
	Repeat	435 – 468	34	WD 7

Sequences

	Sequence		Length	Mass (Da)
	A1L3L9 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: A0977A0EE39B368E	FASTA	468	54,523
	10 20 30 40 50 60 MPCSVEDKTG LCGSRYSVMI PELQESVIFS EDSRHYNEKQ TRRQRKSSAD IISTVEFNNT 70 80 90 100 110 120 GELLATGDKG GRVVIFQREQ ENKNQPHRRG EYNVYSTFQS HEPEFDYLKS LEIEEKINKI 130 140 150 160 170 180 RWLPQQNAAY FLLSTNDKTV KLWKVSERDK RPEGYNLKDE EGRIRDPCTI TSLRVPVLRP 190 200 210 220 230 240 MDLMVEATPR RVFSNAHTYH INSISVNSDY ETYMSADDLR INLWNLEITN RSFNIVDIKP 250 260 270 280 290 300 TNMEELTEVI TAAEFHPHNC NTFVYSSSKG TIRLCDMRSS ALCDKHSKLF EEPEDPSNRS 310 320 330 340 350 360 FFSEIISSIS DVKFNHSGRY IMTRDYLTVK VWDLNMENRP IETYQVHDYL RSKLCSLYEN 370 380 390 400 410 420 DCIFDKFECV WNGSDSVIMT GSYNNFFRMF DRNTKRDVTL EASRENSKPR AILKPRKVCV 430 440 450 460 GGKRRKDEIS VDSLDFSKKI LHTAWHPSEN IIAVAATNNL YIFQDKVN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning of a novel B subunit of Xenopus protein phosphatase 2A and its biological activity in oocytes." Iwashita J., Shima H., Nagao M., Sagata N. Biochem. Biophys. Res. Commun. 232:218-222(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Tissue: Ovary.
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Oocyte.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB000406 mRNA. Translation: BAA19100.1. BC130184 mRNA. Translation: AAI30185.1. Different initiation.
RefSeq	NP_001080956.1. NM_001087487.1.
UniGene	Xl.429.
3D structure databases
ProteinModelPortal	A1L3L9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	394301.
KEGG	xla:394301.
Organism-specific databases
CTD	5521.
Xenbase	XB-GENE-946386. ppp2r2b.
Phylogenomic databases
KO	K04354.
Family and domain databases
Gene3D	2.130.10.10. 3 hits.
InterPro	IPR000009. PP2A_PR55. IPR018067. PP2A_PR55_CS. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
PANTHER	PTHR11871. PTHR11871. 1 hit.
PIRSF	PIRSF037309. PP2A_PR55. 1 hit.
PRINTS	PR00600. PP2APR55.
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS01024. PR55_1. 1 hit. PS01025. PR55_2. 1 hit. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

2ABB_XENLA

Accession

Primary (citable) accession number: A1L3L9
Secondary accession number(s): P87345

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	April 3, 2013
This is version 39 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program