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A1L3K1 (UB2SA_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 S-A

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein S-A
Ubiquitin-protein ligase S-A
Gene names
Name:ube2s-a
Synonyms:ube2s.1-a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223Ubiquitin-conjugating enzyme E2 S-A
PRO_0000390431

Sites

Active site951Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
A1L3K1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 10816CE4377BC406

FASTA22324,183
        10         20         30         40         50         60 
MNSNVENLPP HIIRLVYKEV TTLTADPPDG IKVFPNEEDL TDLQVTIEGP EGTPYAGGLF 

        70         80         90        100        110        120 
RMKLLLGKDF PASPPKGYFL TKIFHPNVGP NGEICVNVLK RDWTAELGIR HVLLTIKCLL 

       130        140        150        160        170        180 
IHPNPESALN EEAGRLLLEN YEEYAARARL LTEIHGGACS TSSGRAEATQ DLASGASASS 

       190        200        210        220 
ADPMIPGVLG GAEGPMAKKH AGERDKKLAA KKKLDKKRAL RRL 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC130145 mRNA. Translation: AAI30146.1.
RefSeqNP_001091235.1. NM_001097766.1.
UniGeneXl.74910.

3D structure databases

ProteinModelPortalA1L3K1.
SMRA1L3K1. Positions 6-156.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100037029.
KEGGxla:100037029.

Organism-specific databases

CTD100037029.
XenbaseXB-GENE-6255548. ube2s.

Phylogenomic databases

HOVERGENHBG063308.
KOK10583.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUB2SA_XENLA
AccessionPrimary (citable) accession number: A1L3K1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways