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Protein

Macrophage-expressed gene 1 protein

Gene

Mpeg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage-expressed gene 1 protein
Short name:
Macrophage gene 1 protein
Short name:
Mpg-1
Alternative name(s):
Protein MPS1
Gene namesi
Name:Mpeg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1333743. Mpeg1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 653634ExtracellularSequence analysisAdd
BLAST
Transmembranei654 – 67421HelicalSequence analysisAdd
BLAST
Topological domaini675 – 71339CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 713694Macrophage-expressed gene 1 proteinPRO_5000142312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence analysis
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiA1L314.
PaxDbiA1L314.
PRIDEiA1L314.

PTM databases

PhosphoSiteiA1L314.

Expressioni

Tissue specificityi

Specifically expressed in macrophages.1 Publication

Inductioni

By CSF-1 in fetal liver macrophages.1 Publication

Gene expression databases

CleanExiMM_MPEG1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108573.

Structurei

3D structure databases

ProteinModelPortaliA1L314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 345316MACPFPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MACPF domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IER6. Eukaryota.
ENOG410ZMVS. LUCA.
HOGENOMiHOG000024828.
HOVERGENiHBG057416.
InParanoidiA1L314.
PhylomeDBiA1L314.

Family and domain databases

InterProiIPR020864. MACPF.
[Graphical view]
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]
PROSITEiPS51412. MACPF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1L314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSFMALVLI WMIIACAEAD KPLGETGTTG FQICKNALKL PVLEVLPGGG
60 70 80 90 100
WDNLRNVDMG RVMDLTYTNC KTTEDGQYII PDEVYTIPQK ESNLEMNSEV
110 120 130 140 150
LESWMNYQST TSLSINTELA LFSRVNGKFS TEFQRMKTLQ VKDQAVTTRV
160 170 180 190 200
QVRNRIYTVK TTPTSELSLG FTKALMDICD QLEKNQTKMA TYLAELLILN
210 220 230 240 250
YGTHVITSVD AGAALVQEDH VRSSFLLDNQ NSQNTVTASA GIAFLNIVNF
260 270 280 290 300
KVETDYISQT SLTKDYLSNR TNSRVQSFGG VPFYPGITLE TWQKGITNHL
310 320 330 340 350
VAIDRAGLPL HFFIKPDKLP GLPGPLVKKL SKTVETAVRH YYTFNTHPGC
360 370 380 390 400
TNVDSPNFNF QANMDDDSCD AKVTNFTFGG VYQECTELSG DVLCQNLEQK
410 420 430 440 450
NLLTGDFSCP PGYSPVHLLS QTHEEGYSRL ECKKKCTLKI FCKTVCEDVF
460 470 480 490 500
RVAKAEFRAY WCVAAGQVPD NSGLLFGGVF TDKTINPMTN AQSCPAGYIP
510 520 530 540 550
LNLFESLKVC VSLDYELGFK FSVPFGGFFS CIMGNPLVNS DTAKDVRAPS
560 570 580 590 600
LKKCPGGFSQ HLAVISDGCQ VSYCVKAGIF TGGSLLPVRL PPYTKPPLMS
610 620 630 640 650
QVATNTVIVT NSETARSWIK DPQTNQWKLG EPLELRRAMT VIHGDSNGMS
660 670 680 690 700
GGEAAGITLG VTIALGIVIT LAIYGTRKYK KKEYQEIEEQ ESLVGSLATD
710
ATVLNGEEDP SPA
Length:713
Mass (Da):78,390
Last modified:February 6, 2007 - v1
Checksum:iE5B16F4BFFD27399
GO

Sequence cautioni

The sequence AAA73957.1 differs from that shown. Reason: Frameshift at position 645. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti414 – 4141S → T in AAI29845 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129843 mRNA. Translation: AAI29844.1.
BC129844 mRNA. Translation: AAI29845.1.
L20315 mRNA. Translation: AAA73957.1. Frameshift.
PIRiI52603.
RefSeqiNP_034951.1. NM_010821.1.
UniGeneiMm.3999.

Genome annotation databases

GeneIDi17476.
KEGGimmu:17476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129843 mRNA. Translation: AAI29844.1.
BC129844 mRNA. Translation: AAI29845.1.
L20315 mRNA. Translation: AAA73957.1. Frameshift.
PIRiI52603.
RefSeqiNP_034951.1. NM_010821.1.
UniGeneiMm.3999.

3D structure databases

ProteinModelPortaliA1L314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108573.

PTM databases

PhosphoSiteiA1L314.

Proteomic databases

MaxQBiA1L314.
PaxDbiA1L314.
PRIDEiA1L314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17476.
KEGGimmu:17476.

Organism-specific databases

CTDi219972.
MGIiMGI:1333743. Mpeg1.

Phylogenomic databases

eggNOGiENOG410IER6. Eukaryota.
ENOG410ZMVS. LUCA.
HOGENOMiHOG000024828.
HOVERGENiHBG057416.
InParanoidiA1L314.
PhylomeDBiA1L314.

Miscellaneous databases

NextBioi292124.
PROiA1L314.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MPEG1.

Family and domain databases

InterProiIPR020864. MACPF.
[Graphical view]
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]
PROSITEiPS51412. MACPF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Isolation of a novel macrophage-specific gene by differential cDNA analysis."
    Spilsbury K., O'Mara M.-A., Wu W.M., Rowe P.B., Symonds G., Takayama Y.
    Blood 85:1620-1629(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-713, TISSUE SPECIFICITY, INDUCTION.
    Strain: ICR.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiMPEG1_MOUSE
AccessioniPrimary (citable) accession number: A1L314
Secondary accession number(s): A1L315, Q61889
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 6, 2007
Last modified: November 11, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.